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Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear.
Learn Mem. 2009 Aug; 16(8):486-93.LM

Abstract

After extinction of conditioned fear, memory for the conditioning and extinction experiences becomes context dependent. Fear is suppressed in the extinction context, but renews in other contexts. This study characterizes the neural circuitry underlying the context-dependent retrieval of extinguished fear memories using c-Fos immunohistochemistry. After fear conditioning and extinction to an auditory conditioned stimulus (CS), rats were presented with the extinguished CS in either the extinction context or a second context, and then sacrificed. Presentation of the CS in the extinction context yielded low levels of conditioned freezing and induced c-Fos expression in the infralimbic division of the medial prefrontal cortex, the intercalated nuclei of the amygdala, and the dentate gyrus (DG). In contrast, presentation of the CS outside of the extinction context yielded high levels of conditioned freezing and induced c-Fos expression in the prelimbic division of the medial prefrontal cortex, the lateral and basolateral nuclei of the amygdala, and the medial division of the central nucleus of the amygdala. Hippocampal areas CA1 and CA3 exhibited c-Fos expression when the CS was presented in either context. These data suggest that the context specificity of extinction is mediated by prefrontal modulation of amygdala activity, and that the hippocampus has a fundamental role in contextual memory retrieval.

Authors+Show Affiliations

Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19633138

Citation

Knapska, Ewelina, and Stephen Maren. "Reciprocal Patterns of c-Fos Expression in the Medial Prefrontal Cortex and Amygdala After Extinction and Renewal of Conditioned Fear." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 16, no. 8, 2009, pp. 486-93.
Knapska E, Maren S. Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear. Learn Mem. 2009;16(8):486-93.
Knapska, E., & Maren, S. (2009). Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear. Learning & Memory (Cold Spring Harbor, N.Y.), 16(8), 486-93. https://doi.org/10.1101/lm.1463909
Knapska E, Maren S. Reciprocal Patterns of c-Fos Expression in the Medial Prefrontal Cortex and Amygdala After Extinction and Renewal of Conditioned Fear. Learn Mem. 2009;16(8):486-93. PubMed PMID: 19633138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear. AU - Knapska,Ewelina, AU - Maren,Stephen, Y1 - 2009/07/24/ PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2009/10/16/medline SP - 486 EP - 93 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 16 IS - 8 N2 - After extinction of conditioned fear, memory for the conditioning and extinction experiences becomes context dependent. Fear is suppressed in the extinction context, but renews in other contexts. This study characterizes the neural circuitry underlying the context-dependent retrieval of extinguished fear memories using c-Fos immunohistochemistry. After fear conditioning and extinction to an auditory conditioned stimulus (CS), rats were presented with the extinguished CS in either the extinction context or a second context, and then sacrificed. Presentation of the CS in the extinction context yielded low levels of conditioned freezing and induced c-Fos expression in the infralimbic division of the medial prefrontal cortex, the intercalated nuclei of the amygdala, and the dentate gyrus (DG). In contrast, presentation of the CS outside of the extinction context yielded high levels of conditioned freezing and induced c-Fos expression in the prelimbic division of the medial prefrontal cortex, the lateral and basolateral nuclei of the amygdala, and the medial division of the central nucleus of the amygdala. Hippocampal areas CA1 and CA3 exhibited c-Fos expression when the CS was presented in either context. These data suggest that the context specificity of extinction is mediated by prefrontal modulation of amygdala activity, and that the hippocampus has a fundamental role in contextual memory retrieval. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/19633138/Reciprocal_patterns_of_c_Fos_expression_in_the_medial_prefrontal_cortex_and_amygdala_after_extinction_and_renewal_of_conditioned_fear_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19633138/ DB - PRIME DP - Unbound Medicine ER -