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Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.
Cell Mol Neurobiol. 2010 Jan; 30(1):71-9.CM

Abstract

Consisting of a fragment of ACTH(4-7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke therapy. Previous experiments showed rapid induction of Bdnf, Ngf, and TrkB expression in intact rat hippocampus following Semax treatment. To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO). We have shown for the first time that both Semax and PGP activate the transcription of neurotrophins and their receptors in the cortex of rats subjected to pMCAO. The profiles of transcription alteration under PGP and Semax treatment were partially overlapped. Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion. PGP enhanced the transcription of Bdnf and TrkC 3 h after pMCAO and Ngf, TrkB, TrkC, and TrkA 24 h after pMCAO. The analysis of the transcription alterations under PGP and Semax treatment in the cortex of rats without surgery, sham-operated rats and rats subjected to pMCAO revealed that Semax selectively affected the transcription of neurotrophins and their receptors in the ischemic rat cortex, whereas the influence of PGP was mainly unspecific.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Dmitrieva VG
Human Molecular Genetics Department, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, The Russian Federation. dmiver@img.ras.ru
Povarova OV
No affiliation info available
Skvortsova VI
No affiliation info available
Limborska SA
No affiliation info available
Myasoedov NF
No affiliation info available
Dergunova LV
No affiliation info available

MeSH

Adrenocorticotropic HormoneAnimalsBrain IschemiaCerebral CortexGene Expression RegulationMaleNerve Growth FactorsOligopeptidesPeptide FragmentsRNA, MessengerRatsRats, WistarReceptors, Nerve Growth FactorTranscription, Genetic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19633950

Citation

Dmitrieva, Veronika G., et al. "Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes After Cerebral Ischemia." Cellular and Molecular Neurobiology, vol. 30, no. 1, 2010, pp. 71-9.
Dmitrieva VG, Povarova OV, Skvortsova VI, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010;30(1):71-9.
Dmitrieva, V. G., Povarova, O. V., Skvortsova, V. I., Limborska, S. A., Myasoedov, N. F., & Dergunova, L. V. (2010). Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cellular and Molecular Neurobiology, 30(1), 71-9. https://doi.org/10.1007/s10571-009-9432-0
Dmitrieva VG, et al. Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes After Cerebral Ischemia. Cell Mol Neurobiol. 2010;30(1):71-9. PubMed PMID: 19633950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. AU - Dmitrieva,Veronika G, AU - Povarova,Oksana V, AU - Skvortsova,Veronika I, AU - Limborska,Svetlana A, AU - Myasoedov,Nikolai F, AU - Dergunova,Lyudmila V, Y1 - 2009/07/25/ PY - 2009/05/05/received PY - 2009/07/08/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2010/4/14/medline SP - 71 EP - 9 JF - Cellular and molecular neurobiology JO - Cell Mol Neurobiol VL - 30 IS - 1 N2 - Consisting of a fragment of ACTH(4-7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke therapy. Previous experiments showed rapid induction of Bdnf, Ngf, and TrkB expression in intact rat hippocampus following Semax treatment. To investigate the mRNA expression of neurotrophins and their receptors after treatment with either Semax or PGP, the rat brains were analyzed at three time points following a permanent middle cerebral artery occlusion (pMCAO). We have shown for the first time that both Semax and PGP activate the transcription of neurotrophins and their receptors in the cortex of rats subjected to pMCAO. The profiles of transcription alteration under PGP and Semax treatment were partially overlapped. Semax enhanced the transcription of Bdnf, TrkC, and TrkA 3 h after occlusion, Nt-3 and Ngf 24 h after occlusion, and Ngf 72 h after occlusion. PGP enhanced the transcription of Bdnf and TrkC 3 h after pMCAO and Ngf, TrkB, TrkC, and TrkA 24 h after pMCAO. The analysis of the transcription alterations under PGP and Semax treatment in the cortex of rats without surgery, sham-operated rats and rats subjected to pMCAO revealed that Semax selectively affected the transcription of neurotrophins and their receptors in the ischemic rat cortex, whereas the influence of PGP was mainly unspecific. SN - 1573-6830 UR - https://www.unboundmedicine.com/medline/citation/19633950/Semax_and_Pro_Gly_Pro_activate_the_transcription_of_neurotrophins_and_their_receptor_genes_after_cerebral_ischemia_ L2 - https://doi.org/10.1007/s10571-009-9432-0 DB - PRIME DP - Unbound Medicine ER -