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Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography.
Int J Cardiovasc Imaging. 2009 Oct; 25(7):717-23.IJ

Abstract

Type 2 diabetes mellitus (DM) is associated with a higher risk of cardiovascular disease and atherosclerotic burden. However little data exists in regards to plaque distribution and plaque composition in these patients. To assess for differences in the coronary plaques burden and composition among symptomatic patients with and without type 2 DM using multidetector computed tomography angiography (MDCTA). The 416 symptomatic patients (64% males, mean age: 61 +/- 13 years) with 61 (15%) reporting type 2 DM, who underwent contrast-enhanced MDCTA were studied. Enrolled patients had an intermediate to high pre-test probability of obstructive coronary artery disease. Multivariate analysis was used to correct for differences in age and gender. Patients with type 2 DM were more likely to have significant stenosis >or=70% in at least one coronary segments (33% in type 2 DM vs. 18% in non diabetic, P = 0.013), whereas 11% of both type 2 DM and non diabetics had stenosis of 50-70% (P = NS). Also type 2 DM patients had a higher number of coronary segments with mixed plaques compared to nondiabetic patients (1.67 +/- 2.01 vs. 1.23 +/- 1.61, P = 0.05), whereas no such differences were observed for non-calcified or calcified plaques. Nearly half (43%) of type 2 DM had coronary artery calcium scores (CACS) >or=400 vs. 29% in non diabetic patients (P = 0.03). Patients with type 2 DM tend to have atherosclerotic plaques which are more likely to be mixed in nature. Future studies need to elucidate the prognostic value of differences in plaque characteristics observed according to type 2 diabetic status.

Authors+Show Affiliations

Section of Cardiology, Medical College of Georgia, Augusta, GA 30912, USA. ibebuogu@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19633998

Citation

Ibebuogu, Uzoma N., et al. "Comparison of Atherosclerotic Plaque Burden and Composition Between Diabetic and Non Diabetic Patients By Non Invasive CT Angiography." The International Journal of Cardiovascular Imaging, vol. 25, no. 7, 2009, pp. 717-23.
Ibebuogu UN, Nasir K, Gopal A, et al. Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography. Int J Cardiovasc Imaging. 2009;25(7):717-23.
Ibebuogu, U. N., Nasir, K., Gopal, A., Ahmadi, N., Mao, S. S., Young, E., Honoris, L., Nuguri, V. K., Lee, R. S., Usman, N., Rostami, B., Pal, R., Flores, F., & Budoff, M. J. (2009). Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography. The International Journal of Cardiovascular Imaging, 25(7), 717-23. https://doi.org/10.1007/s10554-009-9483-9
Ibebuogu UN, et al. Comparison of Atherosclerotic Plaque Burden and Composition Between Diabetic and Non Diabetic Patients By Non Invasive CT Angiography. Int J Cardiovasc Imaging. 2009;25(7):717-23. PubMed PMID: 19633998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography. AU - Ibebuogu,Uzoma N, AU - Nasir,Khurram, AU - Gopal,Ambarish, AU - Ahmadi,Naser, AU - Mao,Song S, AU - Young,Emily, AU - Honoris,Lily, AU - Nuguri,Vivek K, AU - Lee,Robert S, AU - Usman,Nudrat, AU - Rostami,Babak, AU - Pal,Raveen, AU - Flores,Ferdinand, AU - Budoff,Matthew J, Y1 - 2009/07/26/ PY - 2008/10/15/received PY - 2009/07/13/accepted PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2009/10/30/medline SP - 717 EP - 23 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 25 IS - 7 N2 - Type 2 diabetes mellitus (DM) is associated with a higher risk of cardiovascular disease and atherosclerotic burden. However little data exists in regards to plaque distribution and plaque composition in these patients. To assess for differences in the coronary plaques burden and composition among symptomatic patients with and without type 2 DM using multidetector computed tomography angiography (MDCTA). The 416 symptomatic patients (64% males, mean age: 61 +/- 13 years) with 61 (15%) reporting type 2 DM, who underwent contrast-enhanced MDCTA were studied. Enrolled patients had an intermediate to high pre-test probability of obstructive coronary artery disease. Multivariate analysis was used to correct for differences in age and gender. Patients with type 2 DM were more likely to have significant stenosis >or=70% in at least one coronary segments (33% in type 2 DM vs. 18% in non diabetic, P = 0.013), whereas 11% of both type 2 DM and non diabetics had stenosis of 50-70% (P = NS). Also type 2 DM patients had a higher number of coronary segments with mixed plaques compared to nondiabetic patients (1.67 +/- 2.01 vs. 1.23 +/- 1.61, P = 0.05), whereas no such differences were observed for non-calcified or calcified plaques. Nearly half (43%) of type 2 DM had coronary artery calcium scores (CACS) >or=400 vs. 29% in non diabetic patients (P = 0.03). Patients with type 2 DM tend to have atherosclerotic plaques which are more likely to be mixed in nature. Future studies need to elucidate the prognostic value of differences in plaque characteristics observed according to type 2 diabetic status. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/19633998/Comparison_of_atherosclerotic_plaque_burden_and_composition_between_diabetic_and_non_diabetic_patients_by_non_invasive_CT_angiography_ L2 - https://doi.org/10.1007/s10554-009-9483-9 DB - PRIME DP - Unbound Medicine ER -