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The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers.
Macromol Biosci 2009; 9(11):1080-9MB

Abstract

An amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.

Authors+Show Affiliations

The CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.No affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19634151

Citation

Mao, Jing, and Zhihua Gan. "The Influence of Pendant Hydroxyl Groups On Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers." Macromolecular Bioscience, vol. 9, no. 11, 2009, pp. 1080-9.
Mao J, Gan Z. The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers. Macromol Biosci. 2009;9(11):1080-9.
Mao, J., & Gan, Z. (2009). The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers. Macromolecular Bioscience, 9(11), pp. 1080-9. doi:10.1002/mabi.200900104.
Mao J, Gan Z. The Influence of Pendant Hydroxyl Groups On Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers. Macromol Biosci. 2009 Nov 10;9(11):1080-9. PubMed PMID: 19634151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers. AU - Mao,Jing, AU - Gan,Zhihua, PY - 2009/7/28/entrez PY - 2009/7/28/pubmed PY - 2010/1/16/medline SP - 1080 EP - 9 JF - Macromolecular bioscience JO - Macromol Biosci VL - 9 IS - 11 N2 - An amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres. SN - 1616-5195 UR - https://www.unboundmedicine.com/medline/citation/19634151/The_influence_of_pendant_hydroxyl_groups_on_enzymatic_degradation_and_drug_delivery_of_amphiphilic_poly[glycidol_block__epsilon_caprolactone_]_copolymers_ L2 - https://doi.org/10.1002/mabi.200900104 DB - PRIME DP - Unbound Medicine ER -