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Co-exposure to environmental lead and manganese affects the intelligence of school-aged children.
Neurotoxicology. 2009 Jul; 30(4):564-71.N

Abstract

BACKGROUND

Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment. However, little is known about the potential association between environmental levels of Pb and Mn on intelligence of children. The aims of the study were to investigate the association of community level of Pb and Mn with the intelligence of school-aged children, and to explore the implications of joint exposure to these two heavy metals.

METHODS

A cross-sectional examination of blood Pb and Mn concentrations was performed, and the intelligence quotient (IQ) was determined for 261 Korean children aged 8-11 years.

RESULTS

The mean blood concentrations of Pb and Mn were 1.73 microg/dL (SD=0.8; median=1.55; range=0.42-4.91) and 14.3 microg/L (SD=3.8; median=14.0; range=5.30-29.02), respectively. Both Pb and Mn showed significant linear relationship with full-scale IQ (Pb, beta=-0.174, p=0.005; Mn, beta=-0.123, p=0.042) and verbal IQ (Pb, beta=-0.187, p=0.003; Mn, beta=-0.127, p=0.036). Blood Pb (DeltaR(2)=0.03) and Mn (DeltaR(2)=0.01) explained 4% of the variances of the full-scale IQ and 5% of the variances of the verbal IQ. When Pb and Mn levels were entered as predictive variables, additive increase in the explained variances was observed. Finally, full-scale IQ and verbal IQ of the children with blood Mn>14 microg/L showed significant association with Pb, whereas group with Mn<14 microg/L did not, suggesting effect modification between Pb and Mn.

CONCLUSIONS

The present study suggests the presence of additive interaction and effect modification between Pb and Mn on the intelligence of school-aged children, suggesting more attention should be paid to preventing the exposure of disadvantaged children to various combinations of toxic materials.

Authors+Show Affiliations

Division of Child & Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 28 Yeongun-Dong, Chongno-Gu, Seoul, 110-744, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19635390

Citation

Kim, Yeni, et al. "Co-exposure to Environmental Lead and Manganese Affects the Intelligence of School-aged Children." Neurotoxicology, vol. 30, no. 4, 2009, pp. 564-71.
Kim Y, Kim BN, Hong YC, et al. Co-exposure to environmental lead and manganese affects the intelligence of school-aged children. Neurotoxicology. 2009;30(4):564-71.
Kim, Y., Kim, B. N., Hong, Y. C., Shin, M. S., Yoo, H. J., Kim, J. W., Bhang, S. Y., & Cho, S. C. (2009). Co-exposure to environmental lead and manganese affects the intelligence of school-aged children. Neurotoxicology, 30(4), 564-71. https://doi.org/10.1016/j.neuro.2009.03.012
Kim Y, et al. Co-exposure to Environmental Lead and Manganese Affects the Intelligence of School-aged Children. Neurotoxicology. 2009;30(4):564-71. PubMed PMID: 19635390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-exposure to environmental lead and manganese affects the intelligence of school-aged children. AU - Kim,Yeni, AU - Kim,Bung-Nyun, AU - Hong,Yun-Chul, AU - Shin,Min-Sup, AU - Yoo,Hee-Jeong, AU - Kim,Jae-Won, AU - Bhang,Soo-Young, AU - Cho,Soo-Churl, Y1 - 2009/04/14/ PY - 2008/12/09/received PY - 2009/03/11/revised PY - 2009/03/11/accepted PY - 2009/7/29/entrez PY - 2009/7/29/pubmed PY - 2009/10/29/medline SP - 564 EP - 71 JF - Neurotoxicology JO - Neurotoxicology VL - 30 IS - 4 N2 - BACKGROUND: Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment. However, little is known about the potential association between environmental levels of Pb and Mn on intelligence of children. The aims of the study were to investigate the association of community level of Pb and Mn with the intelligence of school-aged children, and to explore the implications of joint exposure to these two heavy metals. METHODS: A cross-sectional examination of blood Pb and Mn concentrations was performed, and the intelligence quotient (IQ) was determined for 261 Korean children aged 8-11 years. RESULTS: The mean blood concentrations of Pb and Mn were 1.73 microg/dL (SD=0.8; median=1.55; range=0.42-4.91) and 14.3 microg/L (SD=3.8; median=14.0; range=5.30-29.02), respectively. Both Pb and Mn showed significant linear relationship with full-scale IQ (Pb, beta=-0.174, p=0.005; Mn, beta=-0.123, p=0.042) and verbal IQ (Pb, beta=-0.187, p=0.003; Mn, beta=-0.127, p=0.036). Blood Pb (DeltaR(2)=0.03) and Mn (DeltaR(2)=0.01) explained 4% of the variances of the full-scale IQ and 5% of the variances of the verbal IQ. When Pb and Mn levels were entered as predictive variables, additive increase in the explained variances was observed. Finally, full-scale IQ and verbal IQ of the children with blood Mn>14 microg/L showed significant association with Pb, whereas group with Mn<14 microg/L did not, suggesting effect modification between Pb and Mn. CONCLUSIONS: The present study suggests the presence of additive interaction and effect modification between Pb and Mn on the intelligence of school-aged children, suggesting more attention should be paid to preventing the exposure of disadvantaged children to various combinations of toxic materials. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/19635390/Co_exposure_to_environmental_lead_and_manganese_affects_the_intelligence_of_school_aged_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(09)00075-8 DB - PRIME DP - Unbound Medicine ER -