Tags

Type your tag names separated by a space and hit enter

Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys.
Exp Eye Res. 2009 Dec; 89(6):824-32.EE

Abstract

The goal was to determine the age-related changes in accommodative movements of the lens and ciliary body in rhesus monkeys. Varying levels of accommodation were stimulated via the Edinger-Westphal (E-W) nucleus in 26 rhesus monkeys, aged 6-27 years, and the refractive changes were measured by coincidence refractometry. Centripetal ciliary process (CP) and lens movements were measured by computerized image analysis of goniovideographic images. Ultrasound biomicroscopy (UBM) at 50 MHz was used to visualize and measure accommodative forward movements of the ciliary body in relation to age, accommodative amplitude, and centripetal CP and lens movements. At approximately 3 diopters of accommodation, the amount of centripetal lens movement required did not significantly change with age (p = 0.10; n = 18 monkeys); however, the amount of centripetal CP movement required significantly increased with age (p = 0.01; n = 18 monkeys), while the amount of forward ciliary body movement significantly decreased with age (p = 0.007; n = 11 monkeys). In the middle-aged animals (12-16.5 years), a greater amount of centripetal CP movement was required to induce a given level of lens movement and thereby a given level of accommodation (p = 0.01), compared to the young animals (6-10 yrs). Collectively, the data suggests that, with age, the accommodative system may be attempting to compensate for the loss of forward ciliary body movement by increasing the amount of centripetal CP movement. This, in turn, would allow enough zonular relaxation to achieve the magnitude of centripetal lens movement necessary for a given amplitude of accommodation.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792-3284, USA. macroft@wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19635475

Citation

Croft, Mary Ann, et al. "Age-related Changes in Centripetal Ciliary Body Movement Relative to Centripetal Lens Movement in Monkeys." Experimental Eye Research, vol. 89, no. 6, 2009, pp. 824-32.
Croft MA, McDonald JP, Nadkarni NV, et al. Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys. Exp Eye Res. 2009;89(6):824-32.
Croft, M. A., McDonald, J. P., Nadkarni, N. V., Lin, T. L., & Kaufman, P. L. (2009). Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys. Experimental Eye Research, 89(6), 824-32. https://doi.org/10.1016/j.exer.2009.07.009
Croft MA, et al. Age-related Changes in Centripetal Ciliary Body Movement Relative to Centripetal Lens Movement in Monkeys. Exp Eye Res. 2009;89(6):824-32. PubMed PMID: 19635475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys. AU - Croft,Mary Ann, AU - McDonald,Jared P, AU - Nadkarni,Nivedita V, AU - Lin,Ting-Li, AU - Kaufman,Paul L, Y1 - 2009/07/25/ PY - 2008/12/17/received PY - 2009/06/02/revised PY - 2009/07/12/accepted PY - 2009/7/29/entrez PY - 2009/7/29/pubmed PY - 2010/2/6/medline SP - 824 EP - 32 JF - Experimental eye research JO - Exp. Eye Res. VL - 89 IS - 6 N2 - The goal was to determine the age-related changes in accommodative movements of the lens and ciliary body in rhesus monkeys. Varying levels of accommodation were stimulated via the Edinger-Westphal (E-W) nucleus in 26 rhesus monkeys, aged 6-27 years, and the refractive changes were measured by coincidence refractometry. Centripetal ciliary process (CP) and lens movements were measured by computerized image analysis of goniovideographic images. Ultrasound biomicroscopy (UBM) at 50 MHz was used to visualize and measure accommodative forward movements of the ciliary body in relation to age, accommodative amplitude, and centripetal CP and lens movements. At approximately 3 diopters of accommodation, the amount of centripetal lens movement required did not significantly change with age (p = 0.10; n = 18 monkeys); however, the amount of centripetal CP movement required significantly increased with age (p = 0.01; n = 18 monkeys), while the amount of forward ciliary body movement significantly decreased with age (p = 0.007; n = 11 monkeys). In the middle-aged animals (12-16.5 years), a greater amount of centripetal CP movement was required to induce a given level of lens movement and thereby a given level of accommodation (p = 0.01), compared to the young animals (6-10 yrs). Collectively, the data suggests that, with age, the accommodative system may be attempting to compensate for the loss of forward ciliary body movement by increasing the amount of centripetal CP movement. This, in turn, would allow enough zonular relaxation to achieve the magnitude of centripetal lens movement necessary for a given amplitude of accommodation. SN - 1096-0007 UR - https://www.unboundmedicine.com/medline/citation/19635475/Age_related_changes_in_centripetal_ciliary_body_movement_relative_to_centripetal_lens_movement_in_monkeys_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4835(09)00199-7 DB - PRIME DP - Unbound Medicine ER -