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A clinical and magnetoencephalography study of MRI-negative startle epilepsy.
Epilepsy Behav. 2009 Sep; 16(1):166-71.EB

Abstract

OBJECTIVE

The goal of this study was to investigate clinical findings, ictal semiology, and results of video/electroencephalography (video/EEG), and magnetoencephalography (MEG) in patients with startle epilepsy and normal brain MRI.

METHODS

Four patients (mean age 12.5 years) with startle epilepsy were investigated with MRI, video/EEG, and MEG.

RESULTS

Epilepsy diagnosis was established in childhood, and all had spontaneous and reflex seizures. Reflex seizures were triggered by sudden, unexpected sounds and tactile stimuli. The neurological examinations and MRIs were normal. MEG recordings showed focal epileptiform activity. An ictal MEG was obtained in one patient. Source modeling yielded dipole sources in right central frontal region.

CONCLUSION

The present study demonstrates that the origin of epileptiform activity in startle epilepsy can be localized in brain areas associated with supplementary motor seizures, even in patients with normal brain MRI. MEG adds complementary information to the localization of epileptiform activity and can be useful in planning invasive studies in cases evaluated for epilepsy surgery.

Authors+Show Affiliations

Epilepsy Unit, Department of Neurology, Hospital Clínico San Carlos, Madrid, Spain. garciamorales2@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19635686

Citation

García-Morales, Irene, et al. "A Clinical and Magnetoencephalography Study of MRI-negative Startle Epilepsy." Epilepsy & Behavior : E&B, vol. 16, no. 1, 2009, pp. 166-71.
García-Morales I, Maestú F, Pérez-Jiménez MA, et al. A clinical and magnetoencephalography study of MRI-negative startle epilepsy. Epilepsy Behav. 2009;16(1):166-71.
García-Morales, I., Maestú, F., Pérez-Jiménez, M. A., Elices, E., Ortiz, T., Alvarez-Linera, J., & Gil-Nagel, A. (2009). A clinical and magnetoencephalography study of MRI-negative startle epilepsy. Epilepsy & Behavior : E&B, 16(1), 166-71. https://doi.org/10.1016/j.yebeh.2009.06.020
García-Morales I, et al. A Clinical and Magnetoencephalography Study of MRI-negative Startle Epilepsy. Epilepsy Behav. 2009;16(1):166-71. PubMed PMID: 19635686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A clinical and magnetoencephalography study of MRI-negative startle epilepsy. AU - García-Morales,Irene, AU - Maestú,Fernando, AU - Pérez-Jiménez,María Angeles, AU - Elices,Eloy, AU - Ortiz,Tomás, AU - Alvarez-Linera,Juan, AU - Gil-Nagel,Antonio, Y1 - 2009/07/26/ PY - 2009/05/17/received PY - 2009/06/08/revised PY - 2009/06/13/accepted PY - 2009/7/29/entrez PY - 2009/7/29/pubmed PY - 2009/12/16/medline SP - 166 EP - 71 JF - Epilepsy & behavior : E&B JO - Epilepsy Behav VL - 16 IS - 1 N2 - OBJECTIVE: The goal of this study was to investigate clinical findings, ictal semiology, and results of video/electroencephalography (video/EEG), and magnetoencephalography (MEG) in patients with startle epilepsy and normal brain MRI. METHODS: Four patients (mean age 12.5 years) with startle epilepsy were investigated with MRI, video/EEG, and MEG. RESULTS: Epilepsy diagnosis was established in childhood, and all had spontaneous and reflex seizures. Reflex seizures were triggered by sudden, unexpected sounds and tactile stimuli. The neurological examinations and MRIs were normal. MEG recordings showed focal epileptiform activity. An ictal MEG was obtained in one patient. Source modeling yielded dipole sources in right central frontal region. CONCLUSION: The present study demonstrates that the origin of epileptiform activity in startle epilepsy can be localized in brain areas associated with supplementary motor seizures, even in patients with normal brain MRI. MEG adds complementary information to the localization of epileptiform activity and can be useful in planning invasive studies in cases evaluated for epilepsy surgery. SN - 1525-5069 UR - https://www.unboundmedicine.com/medline/citation/19635686/A_clinical_and_magnetoencephalography_study_of_MRI_negative_startle_epilepsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-5050(09)00322-9 DB - PRIME DP - Unbound Medicine ER -