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Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy.
Am J Trop Med Hyg. 2009 Aug; 81(2):302-4.AJ

Abstract

Chronic helminth infections are common in refugee populations and may persist years after immigration. Asymptomatic Strongyloides stercoralis infection raises particular concern because of its potential for complications in immunosuppressed patients. We examined 172 Montagnard refugees resettled to Wake County, North Carolina from 2002 through 2003. Refugees were pretreated with albendazole for five days and screened for health conditions after arrival. Eosinophilia was present in 41 of 171 refugees at the first blood draw. Only 1 of 172 had a stool helminth (Fasciola) identified by microscopy. On repeat testing, 13 people had persistent eosinophilia. Results of serologic analysis for Strongyloides were available in 24 persons. Eosinophil counts decreased significantly after treatment with ivermectin in nine refugees (P = 0.039). Persistent eosinophilia, likely caused by Strongyloides infection, was common in this cohort of Montagnard refugees. Clinicians should understand the limitations of stool microscopy in diagnosis of strongyloidiasis, the limited effectiveness of albendazole in treating strongyloidiasis, and the importance of following-up refugees with persistent eosinophilia.

Authors+Show Affiliations

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. dasgu001@mc.duke.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19635888

Citation

Goswami, Neela D., et al. "Persistent Eosinophilia and Strongyloides Infection in Montagnard Refugees After Presumptive Albendazole Therapy." The American Journal of Tropical Medicine and Hygiene, vol. 81, no. 2, 2009, pp. 302-4.
Goswami ND, Shah JJ, Corey GR, et al. Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy. Am J Trop Med Hyg. 2009;81(2):302-4.
Goswami, N. D., Shah, J. J., Corey, G. R., & Stout, J. E. (2009). Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy. The American Journal of Tropical Medicine and Hygiene, 81(2), 302-4.
Goswami ND, et al. Persistent Eosinophilia and Strongyloides Infection in Montagnard Refugees After Presumptive Albendazole Therapy. Am J Trop Med Hyg. 2009;81(2):302-4. PubMed PMID: 19635888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy. AU - Goswami,Neela D, AU - Shah,J Jina, AU - Corey,G Ralph, AU - Stout,Jason E, PY - 2009/7/29/entrez PY - 2009/7/29/pubmed PY - 2009/8/22/medline SP - 302 EP - 4 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 81 IS - 2 N2 - Chronic helminth infections are common in refugee populations and may persist years after immigration. Asymptomatic Strongyloides stercoralis infection raises particular concern because of its potential for complications in immunosuppressed patients. We examined 172 Montagnard refugees resettled to Wake County, North Carolina from 2002 through 2003. Refugees were pretreated with albendazole for five days and screened for health conditions after arrival. Eosinophilia was present in 41 of 171 refugees at the first blood draw. Only 1 of 172 had a stool helminth (Fasciola) identified by microscopy. On repeat testing, 13 people had persistent eosinophilia. Results of serologic analysis for Strongyloides were available in 24 persons. Eosinophil counts decreased significantly after treatment with ivermectin in nine refugees (P = 0.039). Persistent eosinophilia, likely caused by Strongyloides infection, was common in this cohort of Montagnard refugees. Clinicians should understand the limitations of stool microscopy in diagnosis of strongyloidiasis, the limited effectiveness of albendazole in treating strongyloidiasis, and the importance of following-up refugees with persistent eosinophilia. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/19635888/Persistent_eosinophilia_and_Strongyloides_infection_in_Montagnard_refugees_after_presumptive_albendazole_therapy_ L2 - https://medlineplus.gov/eosinophilicdisorders.html DB - PRIME DP - Unbound Medicine ER -