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Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation.
Am J Respir Cell Mol Biol. 2010 Jun; 42(6):667-75.AJ

Abstract

Activin A is a member of the TGF-beta superfamily and plays a role in allergic inflammation and asthma pathogenesis. Recent evidence suggests that activin A regulates proinflammatory cytokine production and is regulated by inflammatory mediators. In a murine model of acute allergic airway inflammation, we observed previously that increased activin A concentrations in bronchoalveolar lavage (BAL) fluid coincide with Th2 cytokine production in lung-draining lymph nodes and pronounced mucus metaplasia in bronchial epithelium. We therefore hypothesized that IL-13, the key cytokine for mucus production, regulates activin A secretion into BAL fluid in experimental asthma. IL-13 increased BAL fluid activin A concentrations in naive mice and dose dependently induced activin A secretion from cultured human airway epithelium. A key role for IL-13 in the secretion of activin A into the BAL fluid during allergic airway inflammation was confirmed in IL-13-deficient mice. Eosinophils were not involved in this response because there was no difference in BAL fluid activin A concentrations between wild-type and eosinophil-deficient mice. Our data highlight an important role for IL-13 in the regulation of activin A intraepithelially and in BAL fluid in naive mice and during allergic airway inflammation. Given the immunomodulatory and fibrogenic effects of activin A, our findings suggest an important role for IL-13 regulation of activin A in asthma pathogenesis.

Authors+Show Affiliations

Department of Immunology, Monash University, Commercial Road, Melbourne, VIC 3004 Australia. charles.hardy@med.monash.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19635933

Citation

Hardy, Charles L., et al. "Interleukin-13 Regulates Secretion of the Tumor Growth Factor-{beta} Superfamily Cytokine Activin a in Allergic Airway Inflammation." American Journal of Respiratory Cell and Molecular Biology, vol. 42, no. 6, 2010, pp. 667-75.
Hardy CL, Lemasurier JS, Olsson F, et al. Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation. Am J Respir Cell Mol Biol. 2010;42(6):667-75.
Hardy, C. L., Lemasurier, J. S., Olsson, F., Dang, T., Yao, J., Yang, M., Plebanski, M., Phillips, D. J., Mollard, R., Rolland, J. M., & O'Hehir, R. E. (2010). Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation. American Journal of Respiratory Cell and Molecular Biology, 42(6), 667-75. https://doi.org/10.1165/rcmb.2008-0429OC
Hardy CL, et al. Interleukin-13 Regulates Secretion of the Tumor Growth Factor-{beta} Superfamily Cytokine Activin a in Allergic Airway Inflammation. Am J Respir Cell Mol Biol. 2010;42(6):667-75. PubMed PMID: 19635933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation. AU - Hardy,Charles L, AU - Lemasurier,Jeanne S, AU - Olsson,Fredrik, AU - Dang,Thanh, AU - Yao,Jun, AU - Yang,Ming, AU - Plebanski,Magdalena, AU - Phillips,David J, AU - Mollard,Richard, AU - Rolland,Jennifer M, AU - O'Hehir,Robyn E, Y1 - 2009/07/27/ PY - 2009/7/29/entrez PY - 2009/7/29/pubmed PY - 2010/6/11/medline SP - 667 EP - 75 JF - American journal of respiratory cell and molecular biology JO - Am J Respir Cell Mol Biol VL - 42 IS - 6 N2 - Activin A is a member of the TGF-beta superfamily and plays a role in allergic inflammation and asthma pathogenesis. Recent evidence suggests that activin A regulates proinflammatory cytokine production and is regulated by inflammatory mediators. In a murine model of acute allergic airway inflammation, we observed previously that increased activin A concentrations in bronchoalveolar lavage (BAL) fluid coincide with Th2 cytokine production in lung-draining lymph nodes and pronounced mucus metaplasia in bronchial epithelium. We therefore hypothesized that IL-13, the key cytokine for mucus production, regulates activin A secretion into BAL fluid in experimental asthma. IL-13 increased BAL fluid activin A concentrations in naive mice and dose dependently induced activin A secretion from cultured human airway epithelium. A key role for IL-13 in the secretion of activin A into the BAL fluid during allergic airway inflammation was confirmed in IL-13-deficient mice. Eosinophils were not involved in this response because there was no difference in BAL fluid activin A concentrations between wild-type and eosinophil-deficient mice. Our data highlight an important role for IL-13 in the regulation of activin A intraepithelially and in BAL fluid in naive mice and during allergic airway inflammation. Given the immunomodulatory and fibrogenic effects of activin A, our findings suggest an important role for IL-13 regulation of activin A in asthma pathogenesis. SN - 1535-4989 UR - https://www.unboundmedicine.com/medline/citation/19635933/Interleukin_13_regulates_secretion_of_the_tumor_growth_factor_{beta}_superfamily_cytokine_activin_A_in_allergic_airway_inflammation_ L2 - https://www.atsjournals.org/doi/10.1165/rcmb.2008-0429OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -