TY - JOUR T1 - Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation. AU - Hardy,Charles L, AU - Lemasurier,Jeanne S, AU - Olsson,Fredrik, AU - Dang,Thanh, AU - Yao,Jun, AU - Yang,Ming, AU - Plebanski,Magdalena, AU - Phillips,David J, AU - Mollard,Richard, AU - Rolland,Jennifer M, AU - O'Hehir,Robyn E, Y1 - 2009/07/27/ PY - 2009/7/29/entrez PY - 2009/7/29/pubmed PY - 2010/6/11/medline SP - 667 EP - 75 JF - American journal of respiratory cell and molecular biology JO - Am J Respir Cell Mol Biol VL - 42 IS - 6 N2 - Activin A is a member of the TGF-beta superfamily and plays a role in allergic inflammation and asthma pathogenesis. Recent evidence suggests that activin A regulates proinflammatory cytokine production and is regulated by inflammatory mediators. In a murine model of acute allergic airway inflammation, we observed previously that increased activin A concentrations in bronchoalveolar lavage (BAL) fluid coincide with Th2 cytokine production in lung-draining lymph nodes and pronounced mucus metaplasia in bronchial epithelium. We therefore hypothesized that IL-13, the key cytokine for mucus production, regulates activin A secretion into BAL fluid in experimental asthma. IL-13 increased BAL fluid activin A concentrations in naive mice and dose dependently induced activin A secretion from cultured human airway epithelium. A key role for IL-13 in the secretion of activin A into the BAL fluid during allergic airway inflammation was confirmed in IL-13-deficient mice. Eosinophils were not involved in this response because there was no difference in BAL fluid activin A concentrations between wild-type and eosinophil-deficient mice. Our data highlight an important role for IL-13 in the regulation of activin A intraepithelially and in BAL fluid in naive mice and during allergic airway inflammation. Given the immunomodulatory and fibrogenic effects of activin A, our findings suggest an important role for IL-13 regulation of activin A in asthma pathogenesis. SN - 1535-4989 UR - https://www.unboundmedicine.com/medline/citation/19635933/Interleukin_13_regulates_secretion_of_the_tumor_growth_factor_{beta}_superfamily_cytokine_activin_A_in_allergic_airway_inflammation_ L2 - https://www.atsjournals.org/doi/10.1165/rcmb.2008-0429OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -