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Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare.
J Cutan Pathol. 2010 Oct; 37(10):1084-7.JC

Abstract

Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGlambda monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition.

Authors+Show Affiliations

Section of Dermatology, DISEM, University of Genoa, Italy. franco.rongioletti@unige.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19638067

Citation

Rongioletti, Franco, et al. "Scleromyxedema With an Interstitial Granulomatous-like Pattern: a Rare Histologic Variant Mimicking Granuloma Annulare." Journal of Cutaneous Pathology, vol. 37, no. 10, 2010, pp. 1084-7.
Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare. J Cutan Pathol. 2010;37(10):1084-7.
Rongioletti, F., Cozzani, E., & Parodi, A. (2010). Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare. Journal of Cutaneous Pathology, 37(10), 1084-7. https://doi.org/10.1111/j.1600-0560.2009.01386.x
Rongioletti F, Cozzani E, Parodi A. Scleromyxedema With an Interstitial Granulomatous-like Pattern: a Rare Histologic Variant Mimicking Granuloma Annulare. J Cutan Pathol. 2010;37(10):1084-7. PubMed PMID: 19638067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare. AU - Rongioletti,Franco, AU - Cozzani,Emanuele, AU - Parodi,Aurora, Y1 - 2009/07/22/ PY - 2009/7/30/entrez PY - 2009/7/30/pubmed PY - 2010/12/14/medline SP - 1084 EP - 7 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 37 IS - 10 N2 - Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGlambda monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/19638067/Scleromyxedema_with_an_interstitial_granulomatous_like_pattern:_a_rare_histologic_variant_mimicking_granuloma_annulare_ L2 - https://doi.org/10.1111/j.1600-0560.2009.01386.x DB - PRIME DP - Unbound Medicine ER -