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The deformation behavior of multiple red blood cells in a capillary vessel.
J Biomech Eng 2009; 131(7):074504JB

Abstract

The deformation of multiple red blood cells in a capillary flow was studied numerically. The immersed boundary method was used for the fluid red blood cells interaction. The membrane of the red blood cell was modeled as a hyperelastic thin shell. The numerical results show that the apparent viscosity in the capillary flow is more sensitive to the change of shear coefficient of the membrane than the bending coefficient and surface dilation coefficient, and the increase in the shear coefficient results in an increase in the pressure drop in the blood flow in capillary vessels in order to sustain the same flux rate of red blood cells.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Gong X
    Organ and Body Scale Team, Computational Science Research Program, RIKEN, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan. gong@riken.jp
    Sugiyama K
    No affiliation info available
    Takagi S
    No affiliation info available
    Matsumoto Y
    No affiliation info available

    MeSH

    Blood Flow VelocityBlood PressureCapillariesCell SizeCells, CulturedComputer SimulationElastic ModulusErythrocyte MembraneErythrocytesModels, CardiovascularShear Strength

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19640140

    Citation

    Gong, Xiaobo, et al. "The Deformation Behavior of Multiple Red Blood Cells in a Capillary Vessel." Journal of Biomechanical Engineering, vol. 131, no. 7, 2009, p. 074504.
    Gong X, Sugiyama K, Takagi S, et al. The deformation behavior of multiple red blood cells in a capillary vessel. J Biomech Eng. 2009;131(7):074504.
    Gong, X., Sugiyama, K., Takagi, S., & Matsumoto, Y. (2009). The deformation behavior of multiple red blood cells in a capillary vessel. Journal of Biomechanical Engineering, 131(7), p. 074504. doi:10.1115/1.3127255.
    Gong X, et al. The Deformation Behavior of Multiple Red Blood Cells in a Capillary Vessel. J Biomech Eng. 2009;131(7):074504. PubMed PMID: 19640140.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The deformation behavior of multiple red blood cells in a capillary vessel. AU - Gong,Xiaobo, AU - Sugiyama,Kazuyasu, AU - Takagi,Shu, AU - Matsumoto,Yoichiro, PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2009/10/16/medline SP - 074504 EP - 074504 JF - Journal of biomechanical engineering JO - J Biomech Eng VL - 131 IS - 7 N2 - The deformation of multiple red blood cells in a capillary flow was studied numerically. The immersed boundary method was used for the fluid red blood cells interaction. The membrane of the red blood cell was modeled as a hyperelastic thin shell. The numerical results show that the apparent viscosity in the capillary flow is more sensitive to the change of shear coefficient of the membrane than the bending coefficient and surface dilation coefficient, and the increase in the shear coefficient results in an increase in the pressure drop in the blood flow in capillary vessels in order to sustain the same flux rate of red blood cells. SN - 0148-0731 UR - https://www.unboundmedicine.com/medline/citation/19640140/The_deformation_behavior_of_multiple_red_blood_cells_in_a_capillary_vessel_ L2 - https://asmedigitalcollection.asme.org/biomechanical/article-lookup/doi/10.1115/1.3127255 DB - PRIME DP - Unbound Medicine ER -