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Poor adherence to oral bisphosphonate treatment and its consequences: a review of the evidence.
Expert Opin Pharmacother. 2009 Oct; 10(14):2303-15.EO

Abstract

Poor therapeutic adherence is a major issue faced by physicians today. This paper summarizes the adherence rates with oral bisphosphonate (OBP) treatment in clinical practice and their impact on clinical outcomes. Studies systematically demonstrated that overall compliance and persistence with OBPs among osteoporotic women are poor. Although extending dosing intervals improved adherence, the gains are suboptimal. Most importantly, low compliance and persistence rates consistently resulted in increased rates of fractures. The results emphasize the importance of adherence to treatment to achieve optimal antifracture efficacy. There is an urgent need to implement strategies and to encourage physicians to take measures that increase patients' awareness of the need to use osteoporosis medications as directed in order to benefit from them fully.

Authors+Show Affiliations

University of Liège, Department of Public Health, Epidemiology and Health Economics, Liège, Belgium. veronique.rabenda@ulg.ac.beNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19640210

Citation

Rabenda, Véronique, et al. "Poor Adherence to Oral Bisphosphonate Treatment and Its Consequences: a Review of the Evidence." Expert Opinion On Pharmacotherapy, vol. 10, no. 14, 2009, pp. 2303-15.
Rabenda V, Hiligsmann M, Reginster JY. Poor adherence to oral bisphosphonate treatment and its consequences: a review of the evidence. Expert Opin Pharmacother. 2009;10(14):2303-15.
Rabenda, V., Hiligsmann, M., & Reginster, J. Y. (2009). Poor adherence to oral bisphosphonate treatment and its consequences: a review of the evidence. Expert Opinion On Pharmacotherapy, 10(14), 2303-15. https://doi.org/10.1517/14656560903140533
Rabenda V, Hiligsmann M, Reginster JY. Poor Adherence to Oral Bisphosphonate Treatment and Its Consequences: a Review of the Evidence. Expert Opin Pharmacother. 2009;10(14):2303-15. PubMed PMID: 19640210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poor adherence to oral bisphosphonate treatment and its consequences: a review of the evidence. AU - Rabenda,Véronique, AU - Hiligsmann,Michaël, AU - Reginster,Jean-Yves, PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2009/12/16/medline SP - 2303 EP - 15 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 10 IS - 14 N2 - Poor therapeutic adherence is a major issue faced by physicians today. This paper summarizes the adherence rates with oral bisphosphonate (OBP) treatment in clinical practice and their impact on clinical outcomes. Studies systematically demonstrated that overall compliance and persistence with OBPs among osteoporotic women are poor. Although extending dosing intervals improved adherence, the gains are suboptimal. Most importantly, low compliance and persistence rates consistently resulted in increased rates of fractures. The results emphasize the importance of adherence to treatment to achieve optimal antifracture efficacy. There is an urgent need to implement strategies and to encourage physicians to take measures that increase patients' awareness of the need to use osteoporosis medications as directed in order to benefit from them fully. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/19640210/Poor_adherence_to_oral_bisphosphonate_treatment_and_its_consequences:_a_review_of_the_evidence_ L2 - https://www.tandfonline.com/doi/full/10.1517/14656560903140533 DB - PRIME DP - Unbound Medicine ER -