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Neuropsychological functioning of U.S. Gulf War veterans 10 years after the war.
J Int Neuropsychol Soc. 2009 Sep; 15(5):717-29.JI

Abstract

Many U.S. Gulf War-era veterans complained of poor cognition following the war. This study assessed neuropsychological functioning in veterans 10 years after the war through objective tests. 2189 Gulf War-era veterans (1061 deployed, 1128 non-deployed) were examined at 1 of 16 U.S. Veterans Affairs medical centers. Outcomes included neuropsychological domains derived from factor analysis and individual test scores. Deployed veterans performed significantly worse than non-deployed veterans on 2 of 8 factors (motor speed & sustained attention, analysis not corrected for multiple comparisons) and on 4 of 27 individual test variables (Trails A & B, California Verbal Learning Test-List B, and Continuous Performance Test sensitivity, with only Trails B surviving Bonferroni correction). Within deployed veterans, Khamisiyah exposure was negatively correlated with motor speed after controlling for emotional distress. Depressive symptoms and self-reported exposure to toxicants were independently and significantly associated with worse sustained attention. Other factors were also associated with self-reported exposures. The findings were not a result of differential effort across groups. Gulf War deployment is associated with subtle declines of motor speed and sustained attention, despite overall intact neuropsychological functioning. Evidence suggests that toxicant exposures influence both these functions, and depressive symptoms also influence attention.

Authors+Show Affiliations

Research Service, Boston VA Healthcare System, Boston, Massachusetts, USA. rosemary_toomey@hms.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19640317

Citation

Toomey, Rosemary, et al. "Neuropsychological Functioning of U.S. Gulf War Veterans 10 Years After the War." Journal of the International Neuropsychological Society : JINS, vol. 15, no. 5, 2009, pp. 717-29.
Toomey R, Alpern R, Vasterling JJ, et al. Neuropsychological functioning of U.S. Gulf War veterans 10 years after the war. J Int Neuropsychol Soc. 2009;15(5):717-29.
Toomey, R., Alpern, R., Vasterling, J. J., Baker, D. G., Reda, D. J., Lyons, M. J., Henderson, W. G., Kang, H. K., Eisen, S. A., & Murphy, F. M. (2009). Neuropsychological functioning of U.S. Gulf War veterans 10 years after the war. Journal of the International Neuropsychological Society : JINS, 15(5), 717-29. https://doi.org/10.1017/S1355617709990294
Toomey R, et al. Neuropsychological Functioning of U.S. Gulf War Veterans 10 Years After the War. J Int Neuropsychol Soc. 2009;15(5):717-29. PubMed PMID: 19640317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychological functioning of U.S. Gulf War veterans 10 years after the war. AU - Toomey,Rosemary, AU - Alpern,Renee, AU - Vasterling,Jennifer J, AU - Baker,Dewleen G, AU - Reda,Domenic J, AU - Lyons,Michael J, AU - Henderson,William G, AU - Kang,Han K, AU - Eisen,Seth A, AU - Murphy,Frances M, Y1 - 2009/07/29/ PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2009/11/5/medline SP - 717 EP - 29 JF - Journal of the International Neuropsychological Society : JINS JO - J Int Neuropsychol Soc VL - 15 IS - 5 N2 - Many U.S. Gulf War-era veterans complained of poor cognition following the war. This study assessed neuropsychological functioning in veterans 10 years after the war through objective tests. 2189 Gulf War-era veterans (1061 deployed, 1128 non-deployed) were examined at 1 of 16 U.S. Veterans Affairs medical centers. Outcomes included neuropsychological domains derived from factor analysis and individual test scores. Deployed veterans performed significantly worse than non-deployed veterans on 2 of 8 factors (motor speed & sustained attention, analysis not corrected for multiple comparisons) and on 4 of 27 individual test variables (Trails A & B, California Verbal Learning Test-List B, and Continuous Performance Test sensitivity, with only Trails B surviving Bonferroni correction). Within deployed veterans, Khamisiyah exposure was negatively correlated with motor speed after controlling for emotional distress. Depressive symptoms and self-reported exposure to toxicants were independently and significantly associated with worse sustained attention. Other factors were also associated with self-reported exposures. The findings were not a result of differential effort across groups. Gulf War deployment is associated with subtle declines of motor speed and sustained attention, despite overall intact neuropsychological functioning. Evidence suggests that toxicant exposures influence both these functions, and depressive symptoms also influence attention. SN - 1469-7661 UR - https://www.unboundmedicine.com/medline/citation/19640317/Neuropsychological_functioning_of_U_S__Gulf_War_veterans_10_years_after_the_war_ L2 - https://www.cambridge.org/core/product/identifier/S1355617709990294/type/journal_article DB - PRIME DP - Unbound Medicine ER -