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Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa.
Mol Genet Metab 2009; 98(3):319-21MG

Abstract

We report on the successful desensitization of an adult female with Pompe disease who had previously experienced anaphylaxis to intravenous alglucosidase alfa therapy. The starting alglucosidase alfa dose for desensitization was 10mg/kg with gradual dose escalation and desensitization via serial dilution was completed over five infusions. This methodology serves as a means to desensitize patients with prior anaphylactic response to alglucosidase alfa so that enzyme replacement therapy can be utilized.

Authors+Show Affiliations

Division of Medical Genetics, Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908-0386, USA. slipinski@virginia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19640753

Citation

Lipinski, Shawn E., et al. "Desensitization of an Adult Patient With Pompe Disease and a History of Anaphylaxis to Alglucosidase Alfa." Molecular Genetics and Metabolism, vol. 98, no. 3, 2009, pp. 319-21.
Lipinski SE, Lipinski MJ, Burnette A, et al. Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa. Mol Genet Metab. 2009;98(3):319-21.
Lipinski, S. E., Lipinski, M. J., Burnette, A., Platts-Mills, T. A., & Wilson, W. G. (2009). Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa. Molecular Genetics and Metabolism, 98(3), pp. 319-21. doi:10.1016/j.ymgme.2009.07.001.
Lipinski SE, et al. Desensitization of an Adult Patient With Pompe Disease and a History of Anaphylaxis to Alglucosidase Alfa. Mol Genet Metab. 2009;98(3):319-21. PubMed PMID: 19640753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa. AU - Lipinski,Shawn E, AU - Lipinski,Michael J, AU - Burnette,Autumn, AU - Platts-Mills,Thomas A, AU - Wilson,William G, Y1 - 2009/07/07/ PY - 2009/04/25/received PY - 2009/07/01/revised PY - 2009/07/01/accepted PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2010/1/23/medline SP - 319 EP - 21 JF - Molecular genetics and metabolism JO - Mol. Genet. Metab. VL - 98 IS - 3 N2 - We report on the successful desensitization of an adult female with Pompe disease who had previously experienced anaphylaxis to intravenous alglucosidase alfa therapy. The starting alglucosidase alfa dose for desensitization was 10mg/kg with gradual dose escalation and desensitization via serial dilution was completed over five infusions. This methodology serves as a means to desensitize patients with prior anaphylactic response to alglucosidase alfa so that enzyme replacement therapy can be utilized. SN - 1096-7206 UR - https://www.unboundmedicine.com/medline/citation/19640753/Desensitization_of_an_adult_patient_with_Pompe_disease_and_a_history_of_anaphylaxis_to_alglucosidase_alfa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-7192(09)00200-5 DB - PRIME DP - Unbound Medicine ER -