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Impact of pre-morbid depression on health-related quality of life in non-demented Parkinson's disease patients.
Parkinsonism Relat Disord. 2010 Jan; 16(1):21-7.PR

Abstract

The need to understand and improve health-related quality of life (Hr-QoL) in Parkinson's disease (PD) has been emphasized. In order to investigate contributions of depression that existed before the onset of typical motor symptoms ("pre-PD depression"), idiopathic non-demented non-psychotic patients with (n = 32) and without (n = 120) a history of pre-PD depression, free of relevant comorbidity, calliper-matched for age, education and disease duration were evaluated for motor and non-motor disease aspects and Hr-QoL (Parkinson's Disease Questionnaire 39, PDQ-39). History of pre-PD depression was independently associated with higher actual levels of depression and anxiety, poorer sleep quality and mental set shifting, which all contributed to poorer Hr-QoL. Mediation analysis demonstrated significant indirect effects (mediated through the effects on mood/emotion/sleep and/or cognition) of pre-PD depression on PDQ summary index and subscales, but also direct (non-mediated) effects on emotional well-being and body discomfort subscales independent of the sociodemographic, motor/non-motor disease or treatment-related characteristics. Data indicate that for a given level of motor/non-motor PD symptoms severity, history of pre-PD depression contributes to poorer Hr-QoL.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Klepac N
Department of Neurology, University Hospital Centre Zagreb, Zagreb University School of Medicine, Kispatićeva 12, Zagreb, Croatia.
Hajnsek S
No affiliation info available
Trkulja V
No affiliation info available

MeSH

AgedAnalysis of VarianceDepressionFemaleHealth StatusHumansMaleMental Status ScheduleMiddle AgedMorbidityParkinson DiseaseQuality of LifeSeverity of Illness IndexStatistics, NonparametricSurveys and Questionnaires

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19640772

Citation

Klepac, Natasa, et al. "Impact of Pre-morbid Depression On Health-related Quality of Life in Non-demented Parkinson's Disease Patients." Parkinsonism & Related Disorders, vol. 16, no. 1, 2010, pp. 21-7.
Klepac N, Hajnsek S, Trkulja V. Impact of pre-morbid depression on health-related quality of life in non-demented Parkinson's disease patients. Parkinsonism Relat Disord. 2010;16(1):21-7.
Klepac, N., Hajnsek, S., & Trkulja, V. (2010). Impact of pre-morbid depression on health-related quality of life in non-demented Parkinson's disease patients. Parkinsonism & Related Disorders, 16(1), 21-7. https://doi.org/10.1016/j.parkreldis.2009.07.003
Klepac N, Hajnsek S, Trkulja V. Impact of Pre-morbid Depression On Health-related Quality of Life in Non-demented Parkinson's Disease Patients. Parkinsonism Relat Disord. 2010;16(1):21-7. PubMed PMID: 19640772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of pre-morbid depression on health-related quality of life in non-demented Parkinson's disease patients. AU - Klepac,Natasa, AU - Hajnsek,Sanja, AU - Trkulja,Vladimir, Y1 - 2009/07/28/ PY - 2009/02/21/received PY - 2009/07/08/revised PY - 2009/07/10/accepted PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2010/4/24/medline SP - 21 EP - 7 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 16 IS - 1 N2 - The need to understand and improve health-related quality of life (Hr-QoL) in Parkinson's disease (PD) has been emphasized. In order to investigate contributions of depression that existed before the onset of typical motor symptoms ("pre-PD depression"), idiopathic non-demented non-psychotic patients with (n = 32) and without (n = 120) a history of pre-PD depression, free of relevant comorbidity, calliper-matched for age, education and disease duration were evaluated for motor and non-motor disease aspects and Hr-QoL (Parkinson's Disease Questionnaire 39, PDQ-39). History of pre-PD depression was independently associated with higher actual levels of depression and anxiety, poorer sleep quality and mental set shifting, which all contributed to poorer Hr-QoL. Mediation analysis demonstrated significant indirect effects (mediated through the effects on mood/emotion/sleep and/or cognition) of pre-PD depression on PDQ summary index and subscales, but also direct (non-mediated) effects on emotional well-being and body discomfort subscales independent of the sociodemographic, motor/non-motor disease or treatment-related characteristics. Data indicate that for a given level of motor/non-motor PD symptoms severity, history of pre-PD depression contributes to poorer Hr-QoL. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/19640772/Impact_of_pre_morbid_depression_on_health_related_quality_of_life_in_non_demented_Parkinson's_disease_patients_ DB - PRIME DP - Unbound Medicine ER -