Tags

Type your tag names separated by a space and hit enter

Systemic involvements and fatalities during Chikungunya epidemic in India, 2006.
J Clin Virol. 2009 Oct; 46(2):145-9.JC

Abstract

BACKGROUND

In addition to classical manifestations of Chikungunya infection, severe infections requiring hospitalization were reported during outbreaks in India in 2006.

OBJECTIVES

To describe the systemic syndromes and risk groups of severe Chikungunya infections.

STUDY DESIGN

We prospectively investigated suspected Chikungunya cases hospitalized in Ahmedabad, Gujarat during September-October 2006, and retrospectively investigated laboratory-confirmed Chikungunya cases hospitalized with neurologic syndromes in Pune, Maharashtra. Hospital records were reviewed for demographic, comorbidity, clinical and laboratory information. Sera and/or cerebrospinal fluid were screened by one or more methods, including virus-specific IgM antibodies, viral RNA and virus isolation.

RESULTS

Among 90 laboratory-confirmed Chikungunya cases hospitalized in Ahmedabad, classical Chikungunya was noted in 25 cases and severe Chikungunya was noted in 65 cases, including non-neurologic (25) and neurologic (40) manifestations. Non-neurologic systemic syndromes in the 65 severe Chikungunya cases included renal (45), hepatic (23), respiratory (21), cardiac (10), and hematologic manifestations (8). Males (50) and those aged >or=60 years (50) were commonly affected with severe Chikungunya, and age >or=60 years represented a significant risk. Comorbidities were seen in 21 cases with multiple comorbidities in 7 cases. Among 18 deaths, 14 were males, 15 were aged >or=60 years and 5 had comorbidities. In Pune, 59 laboratory-confirmed Chikungunya cases with neurologic syndromes were investigated. Neurologic syndromes in 99 cases from Ahmedabad and Pune included encephalitis (57), encephalopathy (42), and myelopathy (14) or myeloneuropathy (12).

CONCLUSIONS

Chikungunya infection can cause systemic complications and probably deaths, especially in elderly adults.

Authors+Show Affiliations

National Institute of Virology, Pune, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19640780

Citation

Tandale, Babasaheb V., et al. "Systemic Involvements and Fatalities During Chikungunya Epidemic in India, 2006." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 46, no. 2, 2009, pp. 145-9.
Tandale BV, Sathe PS, Arankalle VA, et al. Systemic involvements and fatalities during Chikungunya epidemic in India, 2006. J Clin Virol. 2009;46(2):145-9.
Tandale, B. V., Sathe, P. S., Arankalle, V. A., Wadia, R. S., Kulkarni, R., Shah, S. V., Shah, S. K., Sheth, J. K., Sudeep, A. B., Tripathy, A. S., & Mishra, A. C. (2009). Systemic involvements and fatalities during Chikungunya epidemic in India, 2006. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 46(2), 145-9. https://doi.org/10.1016/j.jcv.2009.06.027
Tandale BV, et al. Systemic Involvements and Fatalities During Chikungunya Epidemic in India, 2006. J Clin Virol. 2009;46(2):145-9. PubMed PMID: 19640780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic involvements and fatalities during Chikungunya epidemic in India, 2006. AU - Tandale,Babasaheb V, AU - Sathe,Padmakar S, AU - Arankalle,Vidya A, AU - Wadia,R S, AU - Kulkarni,Rahul, AU - Shah,Sudhir V, AU - Shah,Sanjeev K, AU - Sheth,Jay K, AU - Sudeep,A B, AU - Tripathy,Anuradha S, AU - Mishra,Akhilesh C, Y1 - 2009/07/28/ PY - 2008/12/16/received PY - 2009/06/26/revised PY - 2009/06/29/accepted PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2009/12/23/medline SP - 145 EP - 9 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 46 IS - 2 N2 - BACKGROUND: In addition to classical manifestations of Chikungunya infection, severe infections requiring hospitalization were reported during outbreaks in India in 2006. OBJECTIVES: To describe the systemic syndromes and risk groups of severe Chikungunya infections. STUDY DESIGN: We prospectively investigated suspected Chikungunya cases hospitalized in Ahmedabad, Gujarat during September-October 2006, and retrospectively investigated laboratory-confirmed Chikungunya cases hospitalized with neurologic syndromes in Pune, Maharashtra. Hospital records were reviewed for demographic, comorbidity, clinical and laboratory information. Sera and/or cerebrospinal fluid were screened by one or more methods, including virus-specific IgM antibodies, viral RNA and virus isolation. RESULTS: Among 90 laboratory-confirmed Chikungunya cases hospitalized in Ahmedabad, classical Chikungunya was noted in 25 cases and severe Chikungunya was noted in 65 cases, including non-neurologic (25) and neurologic (40) manifestations. Non-neurologic systemic syndromes in the 65 severe Chikungunya cases included renal (45), hepatic (23), respiratory (21), cardiac (10), and hematologic manifestations (8). Males (50) and those aged >or=60 years (50) were commonly affected with severe Chikungunya, and age >or=60 years represented a significant risk. Comorbidities were seen in 21 cases with multiple comorbidities in 7 cases. Among 18 deaths, 14 were males, 15 were aged >or=60 years and 5 had comorbidities. In Pune, 59 laboratory-confirmed Chikungunya cases with neurologic syndromes were investigated. Neurologic syndromes in 99 cases from Ahmedabad and Pune included encephalitis (57), encephalopathy (42), and myelopathy (14) or myeloneuropathy (12). CONCLUSIONS: Chikungunya infection can cause systemic complications and probably deaths, especially in elderly adults. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/19640780/Systemic_involvements_and_fatalities_during_Chikungunya_epidemic_in_India_2006_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(09)00322-9 DB - PRIME DP - Unbound Medicine ER -