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The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: multivariate analyses.
Clin Neurophysiol. 2009 Sep; 120(9):1683-6.CN

Abstract

OBJECTIVE

Previous studies have shown that age, gender, and body mass index (BMI) affect amplitude of sensory nerve action potentials (SNAP), but the total effects of multiple factors or the most prominently affected nerves have not been elucidated. This study systematically investigated effects of these factors.

METHODS

Amplitude of SNAP of the median, ulnar, superficial radial, superficial peroneal, and sural nerves was measured in 105 healthy subjects. The effects of age, gender, and BMI on each nerve were estimated by multivariate linear regression analysis.

RESULTS

SNAP amplitude decreased with age in all five nerves. Women had greater SNAP amplitude than men in the upper limb nerves (median, ulnar, and radial), but not in the lower limb nerves (peroneal and sural). Similarly, greater BMI was associated with smaller amplitudes in the upper limb nerves, but not in the lower limb nerves. Multivariate analyses showed the three factors explained 50% of the variation in the median nerve, 46% in the ulnar nerve, and 22-32% in the remaining nerves.

CONCLUSIONS

The effects of age, gender, and BMI on SNAP amplitudes are not identical in different sensory nerves. Age was strongly correlated with SNAP amplitude in the nerves tested, whereas gender and BMI affect amplitudes only in the upper limb nerves.

SIGNIFICANCE

Age, gender, and BMI should be taken into account in clinical practice, but the extent of influence depends on the sensory nerves examined.

Authors+Show Affiliations

Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19640782

Citation

Fujimaki, Yumi, et al. "The Effects of Age, Gender, and Body Mass Index On Amplitude of Sensory Nerve Action Potentials: Multivariate Analyses." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 120, no. 9, 2009, pp. 1683-6.
Fujimaki Y, Kuwabara S, Sato Y, et al. The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: multivariate analyses. Clin Neurophysiol. 2009;120(9):1683-6.
Fujimaki, Y., Kuwabara, S., Sato, Y., Isose, S., Shibuya, K., Sekiguchi, Y., Nasu, S., Noto, Y., Taniguchi, J., & Misawa, S. (2009). The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: multivariate analyses. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 120(9), 1683-6. https://doi.org/10.1016/j.clinph.2009.06.025
Fujimaki Y, et al. The Effects of Age, Gender, and Body Mass Index On Amplitude of Sensory Nerve Action Potentials: Multivariate Analyses. Clin Neurophysiol. 2009;120(9):1683-6. PubMed PMID: 19640782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: multivariate analyses. AU - Fujimaki,Yumi, AU - Kuwabara,Satoshi, AU - Sato,Yasunori, AU - Isose,Sagiri, AU - Shibuya,Kazumoto, AU - Sekiguchi,Yukari, AU - Nasu,Saiko, AU - Noto,Yuichi, AU - Taniguchi,Junko, AU - Misawa,Sonoko, Y1 - 2009/07/28/ PY - 2009/03/25/received PY - 2009/06/28/revised PY - 2009/06/30/accepted PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2009/9/24/medline SP - 1683 EP - 6 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 120 IS - 9 N2 - OBJECTIVE: Previous studies have shown that age, gender, and body mass index (BMI) affect amplitude of sensory nerve action potentials (SNAP), but the total effects of multiple factors or the most prominently affected nerves have not been elucidated. This study systematically investigated effects of these factors. METHODS: Amplitude of SNAP of the median, ulnar, superficial radial, superficial peroneal, and sural nerves was measured in 105 healthy subjects. The effects of age, gender, and BMI on each nerve were estimated by multivariate linear regression analysis. RESULTS: SNAP amplitude decreased with age in all five nerves. Women had greater SNAP amplitude than men in the upper limb nerves (median, ulnar, and radial), but not in the lower limb nerves (peroneal and sural). Similarly, greater BMI was associated with smaller amplitudes in the upper limb nerves, but not in the lower limb nerves. Multivariate analyses showed the three factors explained 50% of the variation in the median nerve, 46% in the ulnar nerve, and 22-32% in the remaining nerves. CONCLUSIONS: The effects of age, gender, and BMI on SNAP amplitudes are not identical in different sensory nerves. Age was strongly correlated with SNAP amplitude in the nerves tested, whereas gender and BMI affect amplitudes only in the upper limb nerves. SIGNIFICANCE: Age, gender, and BMI should be taken into account in clinical practice, but the extent of influence depends on the sensory nerves examined. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/19640782/The_effects_of_age_gender_and_body_mass_index_on_amplitude_of_sensory_nerve_action_potentials:_multivariate_analyses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(09)00421-0 DB - PRIME DP - Unbound Medicine ER -