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Grape juice, berries, and walnuts affect brain aging and behavior.
J Nutr. 2009 Sep; 139(9):1813S-7S.JN

Abstract

Numerous studies have indicated that individuals consuming a diet containing high amounts of fruits and vegetables exhibit fewer age-related diseases such as Alzheimer's disease. Research from our laboratory has suggested that dietary supplementation with fruit or vegetable extracts high in antioxidants (e.g. blueberries, strawberries, walnuts, and Concord grape juice) can decrease the enhanced vulnerability to oxidative stress that occurs in aging and these reductions are expressed as improvements in behavior. Additional mechanisms involved in the beneficial effects of fruits and vegetables include enhancement of neuronal communication via increases in neuronal signaling and decreases in stress signals induced by oxidative/inflammatory stressors (e.g. nuclear factor kappaB). Moreover, collaborative findings indicate that blueberry or Concord grape juice supplementation in humans with mild cognitive impairment increased verbal memory performance, thus translating our animal findings to humans. Taken together, these results suggest that a greater intake of high-antioxidant foods such as berries, Concord grapes, and walnuts may increase "health span" and enhance cognitive and motor function in aging.

Authors+Show Affiliations

USDA-Agricultural Research Service, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. jim.joseph@ars.usda.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

19640963

Citation

Joseph, James A., et al. "Grape Juice, Berries, and Walnuts Affect Brain Aging and Behavior." The Journal of Nutrition, vol. 139, no. 9, 2009, 1813S-7S.
Joseph JA, Shukitt-Hale B, Willis LM. Grape juice, berries, and walnuts affect brain aging and behavior. J Nutr. 2009;139(9):1813S-7S.
Joseph, J. A., Shukitt-Hale, B., & Willis, L. M. (2009). Grape juice, berries, and walnuts affect brain aging and behavior. The Journal of Nutrition, 139(9), 1813S-7S. https://doi.org/10.3945/jn.109.108266
Joseph JA, Shukitt-Hale B, Willis LM. Grape Juice, Berries, and Walnuts Affect Brain Aging and Behavior. J Nutr. 2009;139(9):1813S-7S. PubMed PMID: 19640963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Grape juice, berries, and walnuts affect brain aging and behavior. AU - Joseph,James A, AU - Shukitt-Hale,Barbara, AU - Willis,Lauren M, Y1 - 2009/07/29/ PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2009/9/18/medline SP - 1813S EP - 7S JF - The Journal of nutrition JO - J Nutr VL - 139 IS - 9 N2 - Numerous studies have indicated that individuals consuming a diet containing high amounts of fruits and vegetables exhibit fewer age-related diseases such as Alzheimer's disease. Research from our laboratory has suggested that dietary supplementation with fruit or vegetable extracts high in antioxidants (e.g. blueberries, strawberries, walnuts, and Concord grape juice) can decrease the enhanced vulnerability to oxidative stress that occurs in aging and these reductions are expressed as improvements in behavior. Additional mechanisms involved in the beneficial effects of fruits and vegetables include enhancement of neuronal communication via increases in neuronal signaling and decreases in stress signals induced by oxidative/inflammatory stressors (e.g. nuclear factor kappaB). Moreover, collaborative findings indicate that blueberry or Concord grape juice supplementation in humans with mild cognitive impairment increased verbal memory performance, thus translating our animal findings to humans. Taken together, these results suggest that a greater intake of high-antioxidant foods such as berries, Concord grapes, and walnuts may increase "health span" and enhance cognitive and motor function in aging. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/19640963/Grape_juice_berries_and_walnuts_affect_brain_aging_and_behavior_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.108266 DB - PRIME DP - Unbound Medicine ER -