Tags

Type your tag names separated by a space and hit enter

Adrenergic supersensitivity in parkinsonians with orthostatic hypotension.
Eur J Clin Invest. 1990 Dec; 20(6):613-9.EJ

Abstract

The adrenergic status was studied through evaluation of platelet alpha 2-adrenoceptor number [(3H]yohimbine binding sites), plasma catecholamine levels and blood pressure response to noradrenaline infusion in three groups of subjects (1) Parkinsonians with orthostatic hypotension; (2) Parkinsonians without orthostatic hypotension; and (3) control subjects. In Parkinsonians with orthostatic hypotension, systolic and diastolic blood pressures significantly (P less than 0.05) decreased from 144 +/- 9 and 76 +/- 6 mmHg in the lying position to 95 +/- 12 and 60 +/- 7 mmHg after 5 min standing. In these patients, noradrenaline plasma levels were significantly low (62 +/- 11 pg ml-1, (P less than 0.05) when compared with controls (219 +/- 13 pg ml-1) whereas no difference was noticed in Parkinsonians without orthostatic hypotension (195 +/- 14 pg ml-1). The noradrenaline dose required for a 25 mmHg increase in systolic blood pressure was significantly (P less than 0.01) lower in Parkinsonians with orthostatic hypotension (0.19 +/- 0.03 microgram kg-1) when compared with Parkinsonians without orthostatic hypotension (0.86 +/- 0.11 microgram kg-1) or with controls (0.68 +/- 0.1 microgram kg-1). Platelet alpha 2-adrenoceptor number was higher in Parkinsonians with orthostatic hypotension (313 +/- 52 fmol mg-1 protein) than in Parkinsonians without orthostatic hypotension (168 +/- 9 fmol mg-1 protein) or in controls (175 +/- 4 fmol mg-1 protein) with no change in Kd. This study demonstrates that in patients with Parkinson's disease, orthostatic hypotension is associated with an increase in both vascular sensitivity to noradrenaline and platelet alpha 2-adrenoceptor number.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Senard JM
Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medicine, Centre Hospitalier Universitaire, Toulouse, France.
Valet P
No affiliation info available
Durrieu G
No affiliation info available
Berlan M
No affiliation info available
Tran MA
No affiliation info available
Montastruc JL
No affiliation info available
Rascol A
No affiliation info available
Montastruc P
No affiliation info available

MeSH

AgedAutonomic Nervous SystemBlood PlateletsBlood PressureEpinephrineFemaleHumansHypotension, OrthostaticMaleMiddle AgedNorepinephrineParkinson DiseaseReceptors, Adrenergic, alphaYohimbine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1964123

Citation

Senard, J M., et al. "Adrenergic Supersensitivity in Parkinsonians With Orthostatic Hypotension." European Journal of Clinical Investigation, vol. 20, no. 6, 1990, pp. 613-9.
Senard JM, Valet P, Durrieu G, et al. Adrenergic supersensitivity in parkinsonians with orthostatic hypotension. Eur J Clin Invest. 1990;20(6):613-9.
Senard, J. M., Valet, P., Durrieu, G., Berlan, M., Tran, M. A., Montastruc, J. L., Rascol, A., & Montastruc, P. (1990). Adrenergic supersensitivity in parkinsonians with orthostatic hypotension. European Journal of Clinical Investigation, 20(6), 613-9.
Senard JM, et al. Adrenergic Supersensitivity in Parkinsonians With Orthostatic Hypotension. Eur J Clin Invest. 1990;20(6):613-9. PubMed PMID: 1964123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adrenergic supersensitivity in parkinsonians with orthostatic hypotension. AU - Senard,J M, AU - Valet,P, AU - Durrieu,G, AU - Berlan,M, AU - Tran,M A, AU - Montastruc,J L, AU - Rascol,A, AU - Montastruc,P, PY - 1990/12/1/pubmed PY - 1990/12/1/medline PY - 1990/12/1/entrez SP - 613 EP - 9 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 20 IS - 6 N2 - The adrenergic status was studied through evaluation of platelet alpha 2-adrenoceptor number [(3H]yohimbine binding sites), plasma catecholamine levels and blood pressure response to noradrenaline infusion in three groups of subjects (1) Parkinsonians with orthostatic hypotension; (2) Parkinsonians without orthostatic hypotension; and (3) control subjects. In Parkinsonians with orthostatic hypotension, systolic and diastolic blood pressures significantly (P less than 0.05) decreased from 144 +/- 9 and 76 +/- 6 mmHg in the lying position to 95 +/- 12 and 60 +/- 7 mmHg after 5 min standing. In these patients, noradrenaline plasma levels were significantly low (62 +/- 11 pg ml-1, (P less than 0.05) when compared with controls (219 +/- 13 pg ml-1) whereas no difference was noticed in Parkinsonians without orthostatic hypotension (195 +/- 14 pg ml-1). The noradrenaline dose required for a 25 mmHg increase in systolic blood pressure was significantly (P less than 0.01) lower in Parkinsonians with orthostatic hypotension (0.19 +/- 0.03 microgram kg-1) when compared with Parkinsonians without orthostatic hypotension (0.86 +/- 0.11 microgram kg-1) or with controls (0.68 +/- 0.1 microgram kg-1). Platelet alpha 2-adrenoceptor number was higher in Parkinsonians with orthostatic hypotension (313 +/- 52 fmol mg-1 protein) than in Parkinsonians without orthostatic hypotension (168 +/- 9 fmol mg-1 protein) or in controls (175 +/- 4 fmol mg-1 protein) with no change in Kd. This study demonstrates that in patients with Parkinson's disease, orthostatic hypotension is associated with an increase in both vascular sensitivity to noradrenaline and platelet alpha 2-adrenoceptor number.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/1964123/Adrenergic_supersensitivity_in_parkinsonians_with_orthostatic_hypotension_ DB - PRIME DP - Unbound Medicine ER -