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Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity.
Antivir Chem Chemother. 2009; 19(6):235-42.AC

Abstract

BACKGROUND

Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy.

METHODS

In this study, we analysed polysaccharide fractions isolated from Sebdenia polydactyla.

RESULTS

The purified xylomannan sulfate and its further sulfated derivatives showed strong activity against herpes simplex virus type-1 (HSV-1). Their 50% inhibitory concentration values were in the range 0.35-2.8 microg/ml and they lacked cytotoxicity at concentrations up to 1,000 microg/ml. The major polysaccharide, which had 0.6 sulfate groups per monomer unit and an apparent molecular mass of 150 kDa, contained a backbone of alpha-(1-->3)-linked d-mannopyranosyl residues substituted at position 6 with a single stub of beta-d-xylopyranosyl residues.

CONCLUSIONS

The degree of sulfation seemed to play an important role because desulfation and/or further sulfation of the isolated macromolecules largely influenced their in vitro anti-HSV-1 activity.

Links

Publisher Full Text
journals.sagepub.com
journals.sagepub.com

Authors+Show Affiliations

Ghosh T
Natural Products Laboratory, Department of Chemistry, University of Burdwan, West Bengal, India.
Pujol CA
No affiliation info available
Damonte EB
No affiliation info available
Sinha S
No affiliation info available
Ray B
No affiliation info available

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsGlycosidesHIV-1Magnetic Resonance SpectroscopyMolecular WeightPolysaccharidesSeaweedSulfuric AcidsVero Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19641232

Citation

Ghosh, Tuhin, et al. "Sulfated Xylomannans From the Red Seaweed Sebdenia Polydactyla: Structural Features, Chemical Modification and Antiviral Activity." Antiviral Chemistry & Chemotherapy, vol. 19, no. 6, 2009, pp. 235-42.
Ghosh T, Pujol CA, Damonte EB, et al. Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity. Antivir Chem Chemother. 2009;19(6):235-42.
Ghosh, T., Pujol, C. A., Damonte, E. B., Sinha, S., & Ray, B. (2009). Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity. Antiviral Chemistry & Chemotherapy, 19(6), 235-42.
Ghosh T, et al. Sulfated Xylomannans From the Red Seaweed Sebdenia Polydactyla: Structural Features, Chemical Modification and Antiviral Activity. Antivir Chem Chemother. 2009;19(6):235-42. PubMed PMID: 19641232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity. AU - Ghosh,Tuhin, AU - Pujol,Carlos Alberto, AU - Damonte,Elsa Beatriz, AU - Sinha,Sharmistha, AU - Ray,Bimalendu, PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2010/4/7/medline SP - 235 EP - 42 JF - Antiviral chemistry & chemotherapy JO - Antivir Chem Chemother VL - 19 IS - 6 N2 - BACKGROUND: Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy. METHODS: In this study, we analysed polysaccharide fractions isolated from Sebdenia polydactyla. RESULTS: The purified xylomannan sulfate and its further sulfated derivatives showed strong activity against herpes simplex virus type-1 (HSV-1). Their 50% inhibitory concentration values were in the range 0.35-2.8 microg/ml and they lacked cytotoxicity at concentrations up to 1,000 microg/ml. The major polysaccharide, which had 0.6 sulfate groups per monomer unit and an apparent molecular mass of 150 kDa, contained a backbone of alpha-(1-->3)-linked d-mannopyranosyl residues substituted at position 6 with a single stub of beta-d-xylopyranosyl residues. CONCLUSIONS: The degree of sulfation seemed to play an important role because desulfation and/or further sulfation of the isolated macromolecules largely influenced their in vitro anti-HSV-1 activity. SN - 2040-2066 UR - https://www.unboundmedicine.com/medline/citation/19641232/Sulfated_xylomannans_from_the_red_seaweed_Sebdenia_polydactyla:_structural_features_chemical_modification_and_antiviral_activity_ L2 - https://journals.sagepub.com/doi/10.1177/095632020901900603?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -