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Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides.
Postgrad Med. 2009 Jul; 121(4):145-53.PM

Abstract

Triglyceride (TG) levels can increase for numerous reasons, including a sedentary lifestyle, an unhealthy diet, especially one rich in refined carbohydrates, and comorbidities. According to the National Cholesterol Education Program (NCEP), the normal TG level is < 150 mg/dL. Patients with very high TG (VHTG) levels (> or = 500 mg/dL) should be promptly managed and treated to reach lipid treatment goals, as determined by the NCEP. Lowering TG levels is the primary management goal in these patients, while lowering low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol levels are secondary goals. Therapeutic lifestyle changes are often recommended initially for patients with elevated TGs; however, concomitant drug therapy is often required. Data show that intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can significantly decrease serum TGs, along with plasma concentrations of certain lipoproteins. Omega-3-acid ethyl esters are available by prescription or as dietary supplements. Clinical trials in adult patients with VHTGs show that four 1 g capsules of prescription omega-3 fatty acids, which contain 465 mg of EPA and 375 mg of DHA per capsule, can effectively decrease TG levels by up to 45%, and is generally well tolerated.

Authors+Show Affiliations

SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. richard.sadovsky@downstate.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19641280

Citation

Sadovsky, Richard, and Penny Kris-Etherton. "Prescription Omega-3-acid Ethyl Esters for the Treatment of Very High Triglycerides." Postgraduate Medicine, vol. 121, no. 4, 2009, pp. 145-53.
Sadovsky R, Kris-Etherton P. Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides. Postgrad Med. 2009;121(4):145-53.
Sadovsky, R., & Kris-Etherton, P. (2009). Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides. Postgraduate Medicine, 121(4), 145-53. https://doi.org/10.3810/pgm.2009.07.2020
Sadovsky R, Kris-Etherton P. Prescription Omega-3-acid Ethyl Esters for the Treatment of Very High Triglycerides. Postgrad Med. 2009;121(4):145-53. PubMed PMID: 19641280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides. AU - Sadovsky,Richard, AU - Kris-Etherton,Penny, PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2009/8/21/medline SP - 145 EP - 53 JF - Postgraduate medicine JO - Postgrad Med VL - 121 IS - 4 N2 - Triglyceride (TG) levels can increase for numerous reasons, including a sedentary lifestyle, an unhealthy diet, especially one rich in refined carbohydrates, and comorbidities. According to the National Cholesterol Education Program (NCEP), the normal TG level is < 150 mg/dL. Patients with very high TG (VHTG) levels (> or = 500 mg/dL) should be promptly managed and treated to reach lipid treatment goals, as determined by the NCEP. Lowering TG levels is the primary management goal in these patients, while lowering low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol levels are secondary goals. Therapeutic lifestyle changes are often recommended initially for patients with elevated TGs; however, concomitant drug therapy is often required. Data show that intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can significantly decrease serum TGs, along with plasma concentrations of certain lipoproteins. Omega-3-acid ethyl esters are available by prescription or as dietary supplements. Clinical trials in adult patients with VHTGs show that four 1 g capsules of prescription omega-3 fatty acids, which contain 465 mg of EPA and 375 mg of DHA per capsule, can effectively decrease TG levels by up to 45%, and is generally well tolerated. SN - 1941-9260 UR - https://www.unboundmedicine.com/medline/citation/19641280/Prescription_omega_3_acid_ethyl_esters_for_the_treatment_of_very_high_triglycerides_ L2 - https://www.tandfonline.com/doi/full/10.3810/pgm.2009.07.2020 DB - PRIME DP - Unbound Medicine ER -