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Relationship between increased body iron stores, oxidative stress and insulin resistance in healthy men.
Ann Nutr Metab 2009; 54(4):268-74AN

Abstract

AIM

The aim of our cross-sectional study was to assess the relationships between body iron stores, oxidative stress, impaired insulin sensitivity and carotid atherosclerosis in a cohort of healthy men in primary prevention of cardiovascular disease.

METHODS

We examined 151 volunteers, aged 35- 60 years. Anthropometric parameters, markers of metabolic syndrome, insulin resistance, inflammatory markers, parameters of oxidative stress and intima-media thickness of common carotid artery were measured.

RESULTS

Ferritin correlated positively with waist circumference, body mass index, impaired insulin sensitivity, plasma triglycerides and inversely with high-density lipoprotein cholesterol. We observed positive correlations between ferritin, oxidized lowdensity lipoprotein and advanced oxidation protein products after adjustment for age, waist circumference, body mass index and measured inflammatory markers (high-sensitivity C-reactive protein, fibrinogen, interleukin-6 and tumor necrosis factor-alpha). There were no significant associations between ferritin and intima-media thickness or markers of endothelial dysfunction. In a stepwise multiple regression analysis, triglycerides, waist circumference and elevated transaminases were independent determinants of the serum ferritin level.

CONCLUSION

Our results provide evidence for a relationship between plasma ferritin and oxidative modification of lipids as well as proteins in vivo. Higher body iron stores may contribute to impaired insulin sensitivity through increased oxidative stress in a cohort of healthy men.

Authors+Show Affiliations

Department of Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, CZ-140 21 Prague 4, Czech Republic. petr.syrovatka@seznam.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19641304

Citation

Syrovatka, Petr, et al. "Relationship Between Increased Body Iron Stores, Oxidative Stress and Insulin Resistance in Healthy Men." Annals of Nutrition & Metabolism, vol. 54, no. 4, 2009, pp. 268-74.
Syrovatka P, Kraml P, Potockova J, et al. Relationship between increased body iron stores, oxidative stress and insulin resistance in healthy men. Ann Nutr Metab. 2009;54(4):268-74.
Syrovatka, P., Kraml, P., Potockova, J., Fialova, L., Vejrazka, M., Crkovska, J., & Andel, M. (2009). Relationship between increased body iron stores, oxidative stress and insulin resistance in healthy men. Annals of Nutrition & Metabolism, 54(4), pp. 268-74. doi:10.1159/000229507.
Syrovatka P, et al. Relationship Between Increased Body Iron Stores, Oxidative Stress and Insulin Resistance in Healthy Men. Ann Nutr Metab. 2009;54(4):268-74. PubMed PMID: 19641304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between increased body iron stores, oxidative stress and insulin resistance in healthy men. AU - Syrovatka,Petr, AU - Kraml,Pavel, AU - Potockova,Jana, AU - Fialova,Lenka, AU - Vejrazka,Martin, AU - Crkovska,Jirina, AU - Andel,Michal, Y1 - 2009/07/27/ PY - 2008/08/13/received PY - 2009/05/06/accepted PY - 2009/7/31/entrez PY - 2009/7/31/pubmed PY - 2010/1/13/medline SP - 268 EP - 74 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 54 IS - 4 N2 - AIM: The aim of our cross-sectional study was to assess the relationships between body iron stores, oxidative stress, impaired insulin sensitivity and carotid atherosclerosis in a cohort of healthy men in primary prevention of cardiovascular disease. METHODS: We examined 151 volunteers, aged 35- 60 years. Anthropometric parameters, markers of metabolic syndrome, insulin resistance, inflammatory markers, parameters of oxidative stress and intima-media thickness of common carotid artery were measured. RESULTS: Ferritin correlated positively with waist circumference, body mass index, impaired insulin sensitivity, plasma triglycerides and inversely with high-density lipoprotein cholesterol. We observed positive correlations between ferritin, oxidized lowdensity lipoprotein and advanced oxidation protein products after adjustment for age, waist circumference, body mass index and measured inflammatory markers (high-sensitivity C-reactive protein, fibrinogen, interleukin-6 and tumor necrosis factor-alpha). There were no significant associations between ferritin and intima-media thickness or markers of endothelial dysfunction. In a stepwise multiple regression analysis, triglycerides, waist circumference and elevated transaminases were independent determinants of the serum ferritin level. CONCLUSION: Our results provide evidence for a relationship between plasma ferritin and oxidative modification of lipids as well as proteins in vivo. Higher body iron stores may contribute to impaired insulin sensitivity through increased oxidative stress in a cohort of healthy men. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/19641304/Relationship_between_increased_body_iron_stores_oxidative_stress_and_insulin_resistance_in_healthy_men_ L2 - https://www.karger.com?DOI=10.1159/000229507 DB - PRIME DP - Unbound Medicine ER -