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Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease.
Brain Res. 2009 Oct 06; 1292:93-9.BR

Abstract

A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (N=240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building, spontaneous alternation, the reversal phase of left-right discrimination learning in a water-filled T-maze, and in retention of passive avoidance learning. The behavioral deficits in transgenic mice start at 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing Alzheimer's disease.

Authors+Show Affiliations

Laboratory of Endocrinology and Genomics, CHUL Research Center (CHUQ) and Department of Anatomy and Physiology, Laval University, 2705 Laurier boul., Québec, Canada. Mohammed.Filali@crchul.ulaval.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19643098

Citation

Filali, Mohammed, and Robert Lalonde. "Age-related Cognitive Decline and Nesting Behavior in an APPswe/PS1 Bigenic Model of Alzheimer's Disease." Brain Research, vol. 1292, 2009, pp. 93-9.
Filali M, Lalonde R. Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Res. 2009;1292:93-9.
Filali, M., & Lalonde, R. (2009). Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Research, 1292, 93-9. https://doi.org/10.1016/j.brainres.2009.07.066
Filali M, Lalonde R. Age-related Cognitive Decline and Nesting Behavior in an APPswe/PS1 Bigenic Model of Alzheimer's Disease. Brain Res. 2009 Oct 6;1292:93-9. PubMed PMID: 19643098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. AU - Filali,Mohammed, AU - Lalonde,Robert, Y1 - 2009/07/28/ PY - 2009/01/23/received PY - 2009/07/13/revised PY - 2009/07/18/accepted PY - 2009/8/1/entrez PY - 2009/8/1/pubmed PY - 2009/11/7/medline SP - 93 EP - 9 JF - Brain research JO - Brain Res VL - 1292 N2 - A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (N=240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building, spontaneous alternation, the reversal phase of left-right discrimination learning in a water-filled T-maze, and in retention of passive avoidance learning. The behavioral deficits in transgenic mice start at 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing Alzheimer's disease. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19643098/Age_related_cognitive_decline_and_nesting_behavior_in_an_APPswe/PS1_bigenic_model_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01530-3 DB - PRIME DP - Unbound Medicine ER -