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Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms.

Abstract

Drugs currently used in the treatment of cognitive impairment and dementia have a very limited therapeutic value, suggesting the necessity to potentially individualize new strategies able to prevent and to slow down the progression of predementia and dementia syndromes. An increasing body of epidemiological evidence suggested that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD) and mild cognitive impairment (MCI). Furthermore, a clear reduction of risk for cognitive decline has been found in population samples with elevated fish consumption, high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. Epidemiological findings demonstrated that high PUFA intake appeared to have borderline non-significant trend for a protective effect against the development of MCI. Several hypotheses could explain the association between dietary unsaturated fatty acids and cognitive functioning, including mechanisms through the co-presence of antioxidant compounds in food groups rich in fatty acids, via atherosclerosis and thrombosis, inflammation, accumulation of b-amyloid, or via an effect in maintaining the structural integrity of neuronal membranes, determining the fluidity of synaptosomal membranes that thereby regulate neuronal transmission. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms only in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired subjects non-APOE epsilon4 carriers. These data together with epidemiological evidence support a possible role of fatty acid intake in maintaining adequate cognitive functioning and possibly for the prevention and management of cognitive decline and dementia, but not when the AD process has already taken over.

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  • Authors+Show Affiliations

    ,

    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy.

    , , , , , ,

    Source

    Ageing research reviews 9:2 2010 Apr pg 184-99

    MeSH

    Aging
    Apolipoprotein E4
    Brain
    Cognition Disorders
    Dementia
    Dietary Fats
    Disease Progression
    Fatty Acids
    Fatty Acids, Unsaturated
    Lipid Metabolism
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    19643207

    Citation

    Solfrizzi, Vincenzo, et al. "Dietary Fatty Acids in Dementia and Predementia Syndromes: Epidemiological Evidence and Possible Underlying Mechanisms." Ageing Research Reviews, vol. 9, no. 2, 2010, pp. 184-99.
    Solfrizzi V, Frisardi V, Capurso C, et al. Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms. Ageing Res Rev. 2010;9(2):184-99.
    Solfrizzi, V., Frisardi, V., Capurso, C., D'Introno, A., Colacicco, A. M., Vendemiale, G., ... Panza, F. (2010). Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms. Ageing Research Reviews, 9(2), pp. 184-99. doi:10.1016/j.arr.2009.07.005.
    Solfrizzi V, et al. Dietary Fatty Acids in Dementia and Predementia Syndromes: Epidemiological Evidence and Possible Underlying Mechanisms. Ageing Res Rev. 2010;9(2):184-99. PubMed PMID: 19643207.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms. AU - Solfrizzi,Vincenzo, AU - Frisardi,Vincenza, AU - Capurso,Cristiano, AU - D'Introno,Alessia, AU - Colacicco,Anna M, AU - Vendemiale,Gianluigi, AU - Capurso,Antonio, AU - Panza,Francesco, Y1 - 2009/07/28/ PY - 2009/06/04/received PY - 2009/07/19/revised PY - 2009/07/20/accepted PY - 2009/8/1/entrez PY - 2009/8/1/pubmed PY - 2010/6/16/medline SP - 184 EP - 99 JF - Ageing research reviews JO - Ageing Res. Rev. VL - 9 IS - 2 N2 - Drugs currently used in the treatment of cognitive impairment and dementia have a very limited therapeutic value, suggesting the necessity to potentially individualize new strategies able to prevent and to slow down the progression of predementia and dementia syndromes. An increasing body of epidemiological evidence suggested that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD) and mild cognitive impairment (MCI). Furthermore, a clear reduction of risk for cognitive decline has been found in population samples with elevated fish consumption, high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. Epidemiological findings demonstrated that high PUFA intake appeared to have borderline non-significant trend for a protective effect against the development of MCI. Several hypotheses could explain the association between dietary unsaturated fatty acids and cognitive functioning, including mechanisms through the co-presence of antioxidant compounds in food groups rich in fatty acids, via atherosclerosis and thrombosis, inflammation, accumulation of b-amyloid, or via an effect in maintaining the structural integrity of neuronal membranes, determining the fluidity of synaptosomal membranes that thereby regulate neuronal transmission. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms only in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired subjects non-APOE epsilon4 carriers. These data together with epidemiological evidence support a possible role of fatty acid intake in maintaining adequate cognitive functioning and possibly for the prevention and management of cognitive decline and dementia, but not when the AD process has already taken over. SN - 1872-9649 UR - https://www.unboundmedicine.com/medline/citation/19643207/Dietary_fatty_acids_in_dementia_and_predementia_syndromes:_epidemiological_evidence_and_possible_underlying_mechanisms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-1637(09)00047-6 DB - PRIME DP - Unbound Medicine ER -