Citation
Mathai, S C., et al. "Disproportionate Elevation of N-terminal Pro-brain Natriuretic Peptide in Scleroderma-related Pulmonary Hypertension." The European Respiratory Journal, vol. 35, no. 1, 2010, pp. 95-104.
Mathai SC, Bueso M, Hummers LK, et al. Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension. Eur Respir J. 2010;35(1):95-104.
Mathai, S. C., Bueso, M., Hummers, L. K., Boyce, D., Lechtzin, N., Le Pavec, J., Campo, A., Champion, H. C., Housten, T., Forfia, P. R., Zaiman, A. L., Wigley, F. M., Girgis, R. E., & Hassoun, P. M. (2010). Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension. The European Respiratory Journal, 35(1), 95-104. https://doi.org/10.1183/09031936.00074309
Mathai SC, et al. Disproportionate Elevation of N-terminal Pro-brain Natriuretic Peptide in Scleroderma-related Pulmonary Hypertension. Eur Respir J. 2010;35(1):95-104. PubMed PMID: 19643943.
TY - JOUR
T1 - Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension.
AU - Mathai,S C,
AU - Bueso,M,
AU - Hummers,L K,
AU - Boyce,D,
AU - Lechtzin,N,
AU - Le Pavec,J,
AU - Campo,A,
AU - Champion,H C,
AU - Housten,T,
AU - Forfia,P R,
AU - Zaiman,A L,
AU - Wigley,F M,
AU - Girgis,R E,
AU - Hassoun,P M,
Y1 - 2009/07/30/
PY - 2009/8/1/entrez
PY - 2009/8/1/pubmed
PY - 2010/3/4/medline
SP - 95
EP - 104
JF - The European respiratory journal
JO - Eur Respir J
VL - 35
IS - 1
N2 - N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of neurohormonal activation that is useful in the diagnosis and prognosis of various forms of pulmonary arterial hypertension (PAH). We sought to characterise and compare NT-proBNP in a cohort of PAH related to systemic sclerosis (PAH-SSc) and idiopathic PAH (IPAH) patients. NT-proBNP levels, collected from PAH-SSc and IPAH patients followed prospectively, were compared and correlated with haemodynamic variables. Cox proportional hazard models were created to assess the predictive value of NT-proBNP. 98 patients (55 PAH-SSc, 43 IPAH) were included. Haemodynamics were similar, except for lower mean pulmonary arterial pressure in PAH-SSc. NT-proBNP levels were significantly higher in PAH-SSc (3,419+/-3,784 versus 1,393+/-1,633 pg x mL(-1); p<0.01) and were more closely related to haemodynamics in PAH-SSc than IPAH. 28 patients died. NT-proBNP predicted survival (hazard ratio (HR) 3.18; p<0.01) in the overall cohort; however, when stratified by group, predicted survival only in PAH-SSc (HR 3.07, p<0.01 versus 2.02, p = 0.29 in IPAH). This is the first description showing NT-proBNP levels are 1) significantly higher in PAH-SSc than IPAH despite less severe haemodynamic perturbations, and 2) stronger predictors of survival in PAH-SSc, suggesting that neurohormonal regulation may differ between PAH-SSc and IPAH. Future studies to define pertinent mechanisms are warranted.
SN - 1399-3003
UR - https://www.unboundmedicine.com/medline/citation/19643943/Disproportionate_elevation_of_N_terminal_pro_brain_natriuretic_peptide_in_scleroderma_related_pulmonary_hypertension_
L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=19643943
DB - PRIME
DP - Unbound Medicine
ER -