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Laboratory-acquired vaccinia virus infection--Virginia, 2008.
MMWR Morb Mortal Wkly Rep. 2009 Jul 31; 58(29):797-800.MM

Abstract

Vaccinia virus (VACV) is the live viral component of smallpox vaccine. Inadvertent exposure to VACV can result in infection, and severe complications can occur in persons with underlying risk factors (e.g., pregnancy, immunodeficiencies, or dermatologic conditions). The Advisory Committee on Immunization Practices (ACIP) recommends smallpox vaccination for laboratory workers who handle nonhighly attenuated VACV strains or other orthopoxviruses (e.g., monkeypox, cowpox, or variola). On July 8, 2008, CDC was notified by a Virginia physician of a suspected case of inadvertent autoinoculation and VACV infection in an unvaccinated laboratory worker. This report describes the subsequent investigations conducted by the Virginia Department of Health and CDC to identify the source of infection and any cases of contact transmission. Of the patient's 102 possible contacts, seven had underlying risk factors for developing serious vaccinia infection. Investigators found no evidence of contact transmission and, based on the results of molecular typing, further concluded that the patient had been exposed to a VACV strain that had contaminated the seed stock from the laboratory where the patient worked. This case underscores the importance of adherence to ACIP vaccination recommendations for laboratory workers and use of safety precautions when working with nonhighly attenuated VACV.

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Authors

Centers for Disease Control and Prevention (CDC)
No affiliation info available

MeSH

AdultAnimalsAnimals, LaboratoryContact TracingHumansMaleMedical Laboratory PersonnelMiceSafetySmallpox VaccineSpecimen HandlingVacciniaVaccinia virusVirginia

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19644439

Citation

Centers for Disease Control and Prevention (CDC). "Laboratory-acquired Vaccinia Virus infection--Virginia, 2008." MMWR. Morbidity and Mortality Weekly Report, vol. 58, no. 29, 2009, pp. 797-800.
Centers for Disease Control and Prevention (CDC). Laboratory-acquired vaccinia virus infection--Virginia, 2008. MMWR Morb Mortal Wkly Rep. 2009;58(29):797-800.
Centers for Disease Control and Prevention (CDC). (2009). Laboratory-acquired vaccinia virus infection--Virginia, 2008. MMWR. Morbidity and Mortality Weekly Report, 58(29), 797-800.
Centers for Disease Control and Prevention (CDC). Laboratory-acquired Vaccinia Virus infection--Virginia, 2008. MMWR Morb Mortal Wkly Rep. 2009 Jul 31;58(29):797-800. PubMed PMID: 19644439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laboratory-acquired vaccinia virus infection--Virginia, 2008. A1 - ,, PY - 2009/8/1/entrez PY - 2009/8/1/pubmed PY - 2009/8/4/medline SP - 797 EP - 800 JF - MMWR. Morbidity and mortality weekly report JO - MMWR Morb Mortal Wkly Rep VL - 58 IS - 29 N2 - Vaccinia virus (VACV) is the live viral component of smallpox vaccine. Inadvertent exposure to VACV can result in infection, and severe complications can occur in persons with underlying risk factors (e.g., pregnancy, immunodeficiencies, or dermatologic conditions). The Advisory Committee on Immunization Practices (ACIP) recommends smallpox vaccination for laboratory workers who handle nonhighly attenuated VACV strains or other orthopoxviruses (e.g., monkeypox, cowpox, or variola). On July 8, 2008, CDC was notified by a Virginia physician of a suspected case of inadvertent autoinoculation and VACV infection in an unvaccinated laboratory worker. This report describes the subsequent investigations conducted by the Virginia Department of Health and CDC to identify the source of infection and any cases of contact transmission. Of the patient's 102 possible contacts, seven had underlying risk factors for developing serious vaccinia infection. Investigators found no evidence of contact transmission and, based on the results of molecular typing, further concluded that the patient had been exposed to a VACV strain that had contaminated the seed stock from the laboratory where the patient worked. This case underscores the importance of adherence to ACIP vaccination recommendations for laboratory workers and use of safety precautions when working with nonhighly attenuated VACV. SN - 1545-861X UR - https://www.unboundmedicine.com/medline/citation/19644439/Laboratory_acquired_vaccinia_virus_infection__Virginia_2008_ L2 - https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5829a1.htm DB - PRIME DP - Unbound Medicine ER -