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Effects of exercise training on noninvasive cardiac measures in patients undergoing long-term hemodialysis: a randomized controlled trial.
Am J Kidney Dis. 2009 Sep; 54(3):511-21.AJ

Abstract

BACKGROUND

Noninvasive screening studies may identify hemodialysis (HD) patients at increased risk of sudden cardiac death. Interventions that improve the findings of such screening studies may reduce sudden cardiac death.

STUDY DESIGN

Randomized and controlled clinical trial.

SETTING & PARTICIPANTS

59 HD patients were randomly assigned to an exercise training group (group A; 30 patients) or control group (group B; 29 patients).

INTERVENTION

Group A participated in a 10-month supervised exercise training program during the HD sessions (3 times weekly).

OUTCOMES

Each risk factor separately and the composite risk score. Patients were considered high risk according to the criteria (aerobic capacity: peak oxygen consumption [Vo(2)peak] < or = 14 mL/kg/min, left ventricular ejection fraction < or = 30%, SD of normal RR intervals [SDNN] < or = 70 milliseconds, positive T-wave alternans, or positive late potentials). Statistical analysis included a 2-group comparison of change scores and analysis of covariance adjusting for baseline.

MEASUREMENTS

At entry and end of the study, Vo(2)peak and left ventricular ejection fraction were estimated, heart rate variability was calculated (measurement of SDNN, mean RR intervals), and the ratio between low- (LF) to high-frequency (HF) components (LF/HF) and late potentials and T-wave alternans were detected.

RESULTS

Baseline measurements were similar between the 2 groups. At follow-up, 9 patients from group A and 20 from group B (P = 0.003) were considered high risk. The change in number of risk markers over time was significantly different between groups (-0.5 +/- 0.7 in group A versus 0.07 +/- 0.3 in group B; P < 0.001). Additionally, the change in Vo(2)peak over time was 3.5 +/- 3.2 in group A and -0.2 +/- 3.5 mL/kg/min in group B (P < 0.001), left ventricular ejection fractions were 3.4% +/- 3.9% and 0.2% +/- 7.7% (P < 0.05), SDNNs were 12.6 +/- 16.3 and -1.1 +/- 10.2 milliseconds (P < 0.001), and LF/HF ratios were 0.3 +/- 0.4 and -0.1 +/- 0.3 (P < 0.001), respectively. Change in numerical score of the signal-averaged electrocardiogram also was found to be statistically different (P < 0.05) between groups.

LIMITATIONS

Clinical outcomes, including survival, were not assessed.

CONCLUSIONS

Exercise training improves aerobic capacity and ameliorates some indicators of risk of sudden cardiac death in HD patients.

Authors+Show Affiliations

Laboratory of Sports Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19646801

Citation

Kouidi, Evangelia J., et al. "Effects of Exercise Training On Noninvasive Cardiac Measures in Patients Undergoing Long-term Hemodialysis: a Randomized Controlled Trial." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 54, no. 3, 2009, pp. 511-21.
Kouidi EJ, Grekas DM, Deligiannis AP. Effects of exercise training on noninvasive cardiac measures in patients undergoing long-term hemodialysis: a randomized controlled trial. Am J Kidney Dis. 2009;54(3):511-21.
Kouidi, E. J., Grekas, D. M., & Deligiannis, A. P. (2009). Effects of exercise training on noninvasive cardiac measures in patients undergoing long-term hemodialysis: a randomized controlled trial. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 54(3), 511-21. https://doi.org/10.1053/j.ajkd.2009.03.009
Kouidi EJ, Grekas DM, Deligiannis AP. Effects of Exercise Training On Noninvasive Cardiac Measures in Patients Undergoing Long-term Hemodialysis: a Randomized Controlled Trial. Am J Kidney Dis. 2009;54(3):511-21. PubMed PMID: 19646801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of exercise training on noninvasive cardiac measures in patients undergoing long-term hemodialysis: a randomized controlled trial. AU - Kouidi,Evangelia J, AU - Grekas,Dimitrios M, AU - Deligiannis,Asterios P, Y1 - 2009/07/30/ PY - 2008/07/15/received PY - 2009/03/20/accepted PY - 2009/8/4/entrez PY - 2009/8/4/pubmed PY - 2009/9/15/medline SP - 511 EP - 21 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 54 IS - 3 N2 - BACKGROUND: Noninvasive screening studies may identify hemodialysis (HD) patients at increased risk of sudden cardiac death. Interventions that improve the findings of such screening studies may reduce sudden cardiac death. STUDY DESIGN: Randomized and controlled clinical trial. SETTING & PARTICIPANTS: 59 HD patients were randomly assigned to an exercise training group (group A; 30 patients) or control group (group B; 29 patients). INTERVENTION: Group A participated in a 10-month supervised exercise training program during the HD sessions (3 times weekly). OUTCOMES: Each risk factor separately and the composite risk score. Patients were considered high risk according to the criteria (aerobic capacity: peak oxygen consumption [Vo(2)peak] < or = 14 mL/kg/min, left ventricular ejection fraction < or = 30%, SD of normal RR intervals [SDNN] < or = 70 milliseconds, positive T-wave alternans, or positive late potentials). Statistical analysis included a 2-group comparison of change scores and analysis of covariance adjusting for baseline. MEASUREMENTS: At entry and end of the study, Vo(2)peak and left ventricular ejection fraction were estimated, heart rate variability was calculated (measurement of SDNN, mean RR intervals), and the ratio between low- (LF) to high-frequency (HF) components (LF/HF) and late potentials and T-wave alternans were detected. RESULTS: Baseline measurements were similar between the 2 groups. At follow-up, 9 patients from group A and 20 from group B (P = 0.003) were considered high risk. The change in number of risk markers over time was significantly different between groups (-0.5 +/- 0.7 in group A versus 0.07 +/- 0.3 in group B; P < 0.001). Additionally, the change in Vo(2)peak over time was 3.5 +/- 3.2 in group A and -0.2 +/- 3.5 mL/kg/min in group B (P < 0.001), left ventricular ejection fractions were 3.4% +/- 3.9% and 0.2% +/- 7.7% (P < 0.05), SDNNs were 12.6 +/- 16.3 and -1.1 +/- 10.2 milliseconds (P < 0.001), and LF/HF ratios were 0.3 +/- 0.4 and -0.1 +/- 0.3 (P < 0.001), respectively. Change in numerical score of the signal-averaged electrocardiogram also was found to be statistically different (P < 0.05) between groups. LIMITATIONS: Clinical outcomes, including survival, were not assessed. CONCLUSIONS: Exercise training improves aerobic capacity and ameliorates some indicators of risk of sudden cardiac death in HD patients. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/19646801/Effects_of_exercise_training_on_noninvasive_cardiac_measures_in_patients_undergoing_long_term_hemodialysis:_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(09)00602-7 DB - PRIME DP - Unbound Medicine ER -