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Peripheral anxiogenic drug injections differentially affect cognitive and habit memory: role of basolateral amygdala.
Neuroscience. 2009 Dec 01; 164(2):457-62.N

Abstract

Findings from single-solution plus-maze tasks that require the use of either place or response learning indicate that post-training intra-basolateral amygdala (BLA) administration of the anxiogenic alpha-2 adrenoreceptor antagonist RS 79948 can both enhance dorsal striatal-dependent response learning and impair hippocampus-dependent place learning. Whether post-training peripheral administration of RS 79948 can also enhance and impair response and place learning respectively, is not known. If peripheral drug administration can also produce this "dual" effect on cognitive and habit memory, it would be of interest to know whether the functional integrity of the BLA is critical. In order to examine these questions, the present experiments combined peripheral administration of RS 79948 with concurrent neural inactivation of the BLA. Adult male Long-Evans rats were trained in place or response learning tasks in a water plus-maze. On days 1-3 of training, rats received post-training peripheral injections of saline or RS 79948 (0.1 mg/kg) combined with intra-BLA injections of saline or the sodium channel blocker bupivacaine (1.0% solution, 0.5 microl). Post-training peripheral injections of RS 79948 enhanced acquisition of response learning, and impaired acquisition of place learning. Bupivacaine infusions into the BLA had no effect on acquisition of either task. However, intra-BLA infusions of bupivacaine blocked both the enhancement of response learning and the impairment of place learning produced by RS 79948. Taken together, the findings indicate that although the functional integrity of BLA is not necessary for acquisition of place and response learning, BLA activity is critical in order for peripheral injections of an anxiogenic drug to differentially modulate hippocampus-dependent and dorsal striatal-dependent memory.

Authors+Show Affiliations

Department of Psychology, Texas A & M University, College Station, TX, USA. mgp@psyc.tamu.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19647048

Citation

Packard, M G., and A Gabriele. "Peripheral Anxiogenic Drug Injections Differentially Affect Cognitive and Habit Memory: Role of Basolateral Amygdala." Neuroscience, vol. 164, no. 2, 2009, pp. 457-62.
Packard MG, Gabriele A. Peripheral anxiogenic drug injections differentially affect cognitive and habit memory: role of basolateral amygdala. Neuroscience. 2009;164(2):457-62.
Packard, M. G., & Gabriele, A. (2009). Peripheral anxiogenic drug injections differentially affect cognitive and habit memory: role of basolateral amygdala. Neuroscience, 164(2), 457-62. https://doi.org/10.1016/j.neuroscience.2009.07.054
Packard MG, Gabriele A. Peripheral Anxiogenic Drug Injections Differentially Affect Cognitive and Habit Memory: Role of Basolateral Amygdala. Neuroscience. 2009 Dec 1;164(2):457-62. PubMed PMID: 19647048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral anxiogenic drug injections differentially affect cognitive and habit memory: role of basolateral amygdala. AU - Packard,M G, AU - Gabriele,A, Y1 - 2009/07/30/ PY - 2009/05/07/received PY - 2009/07/20/revised PY - 2009/07/25/accepted PY - 2009/8/4/entrez PY - 2009/8/4/pubmed PY - 2010/2/13/medline SP - 457 EP - 62 JF - Neuroscience JO - Neuroscience VL - 164 IS - 2 N2 - Findings from single-solution plus-maze tasks that require the use of either place or response learning indicate that post-training intra-basolateral amygdala (BLA) administration of the anxiogenic alpha-2 adrenoreceptor antagonist RS 79948 can both enhance dorsal striatal-dependent response learning and impair hippocampus-dependent place learning. Whether post-training peripheral administration of RS 79948 can also enhance and impair response and place learning respectively, is not known. If peripheral drug administration can also produce this "dual" effect on cognitive and habit memory, it would be of interest to know whether the functional integrity of the BLA is critical. In order to examine these questions, the present experiments combined peripheral administration of RS 79948 with concurrent neural inactivation of the BLA. Adult male Long-Evans rats were trained in place or response learning tasks in a water plus-maze. On days 1-3 of training, rats received post-training peripheral injections of saline or RS 79948 (0.1 mg/kg) combined with intra-BLA injections of saline or the sodium channel blocker bupivacaine (1.0% solution, 0.5 microl). Post-training peripheral injections of RS 79948 enhanced acquisition of response learning, and impaired acquisition of place learning. Bupivacaine infusions into the BLA had no effect on acquisition of either task. However, intra-BLA infusions of bupivacaine blocked both the enhancement of response learning and the impairment of place learning produced by RS 79948. Taken together, the findings indicate that although the functional integrity of BLA is not necessary for acquisition of place and response learning, BLA activity is critical in order for peripheral injections of an anxiogenic drug to differentially modulate hippocampus-dependent and dorsal striatal-dependent memory. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/19647048/Peripheral_anxiogenic_drug_injections_differentially_affect_cognitive_and_habit_memory:_role_of_basolateral_amygdala_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(09)01270-6 DB - PRIME DP - Unbound Medicine ER -