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Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study.
Nutrition. 2010 Apr; 26(4):399-404.N

Abstract

OBJECTIVE

Recent studies have suggested that nuts have favorable effects beyond lipid lowering. We aimed to investigate effect of the Antep pistachio (Pistacia vera L.) on blood glucose, lipid parameters, endothelial function, inflammation, and oxidation in healthy young men living in a controlled environment.

METHODS

A Mediterranean diet was administered to normolipidemic 32 healthy young men (mean age 22 y, range 21-24) for 4 wk. After 4 wk, participants continued to receive the Mediterranean diet but pistachio was added for 4 wk by replacing the monounsaturated fat content constituting approximately 20% of daily caloric intake. Fasting blood samples and brachial endothelial function measurements were performed at baseline and after each diet.

RESULTS

Compared with the Mediterranean diet, the pistachio diet decreased glucose (P<0.001, -8.8+/-8.5%), low-density lipoprotein (P<0.001, -23.2+/-11.9%), total cholesterol (P<0.001, -21.2+/-9.9%), and triacylglycerol (P=0.008, -13.8+/-33.8%) significantly and high-density lipoprotein (P=0.069, -3.1+/-11.7%) non-significantly. Total cholesterol/high-density lipoprotein and low-density lipoprotein/high-density lipoprotein ratios decreased significantly (P<0.001 for both). The pistachio diet significantly improved endothelium-dependent vasodilation (P=0.002, 30% relative increase), decreased serum interleukin-6, total oxidant status, lipid hydroperoxide, and malondialdehyde and increased superoxide dismutase (P<0.001 for all), whereas there was no significant change in C-reactive protein and tumor necrosis factor-alpha levels.

CONCLUSION

In this trial, we demonstrated that a pistachio diet improved blood glucose level, endothelial function, and some indices of inflammation and oxidative status in healthy young men. These findings are in accordance with the idea that nuts, in particular pistachio nuts, have favorable effects beyond lipid lowering that deserve to be evaluated with prospective follow-up studies.

Authors+Show Affiliations

Cardiology Department, Gaziantep University, School of Medicine, Gaziantep, Turkey. drisari@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19647416

Citation

Sari, Ibrahim, et al. "Effect of Pistachio Diet On Lipid Parameters, Endothelial Function, Inflammation, and Oxidative Status: a Prospective Study." Nutrition (Burbank, Los Angeles County, Calif.), vol. 26, no. 4, 2010, pp. 399-404.
Sari I, Baltaci Y, Bagci C, et al. Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study. Nutrition. 2010;26(4):399-404.
Sari, I., Baltaci, Y., Bagci, C., Davutoglu, V., Erel, O., Celik, H., Ozer, O., Aksoy, N., & Aksoy, M. (2010). Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study. Nutrition (Burbank, Los Angeles County, Calif.), 26(4), 399-404. https://doi.org/10.1016/j.nut.2009.05.023
Sari I, et al. Effect of Pistachio Diet On Lipid Parameters, Endothelial Function, Inflammation, and Oxidative Status: a Prospective Study. Nutrition. 2010;26(4):399-404. PubMed PMID: 19647416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study. AU - Sari,Ibrahim, AU - Baltaci,Yasemin, AU - Bagci,Cahit, AU - Davutoglu,Vedat, AU - Erel,Ozcan, AU - Celik,Hakim, AU - Ozer,Orhan, AU - Aksoy,Nur, AU - Aksoy,Mehmet, Y1 - 2009/07/31/ PY - 2008/12/15/received PY - 2009/05/01/revised PY - 2009/05/30/accepted PY - 2009/8/4/entrez PY - 2009/8/4/pubmed PY - 2010/5/28/medline SP - 399 EP - 404 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 26 IS - 4 N2 - OBJECTIVE: Recent studies have suggested that nuts have favorable effects beyond lipid lowering. We aimed to investigate effect of the Antep pistachio (Pistacia vera L.) on blood glucose, lipid parameters, endothelial function, inflammation, and oxidation in healthy young men living in a controlled environment. METHODS: A Mediterranean diet was administered to normolipidemic 32 healthy young men (mean age 22 y, range 21-24) for 4 wk. After 4 wk, participants continued to receive the Mediterranean diet but pistachio was added for 4 wk by replacing the monounsaturated fat content constituting approximately 20% of daily caloric intake. Fasting blood samples and brachial endothelial function measurements were performed at baseline and after each diet. RESULTS: Compared with the Mediterranean diet, the pistachio diet decreased glucose (P<0.001, -8.8+/-8.5%), low-density lipoprotein (P<0.001, -23.2+/-11.9%), total cholesterol (P<0.001, -21.2+/-9.9%), and triacylglycerol (P=0.008, -13.8+/-33.8%) significantly and high-density lipoprotein (P=0.069, -3.1+/-11.7%) non-significantly. Total cholesterol/high-density lipoprotein and low-density lipoprotein/high-density lipoprotein ratios decreased significantly (P<0.001 for both). The pistachio diet significantly improved endothelium-dependent vasodilation (P=0.002, 30% relative increase), decreased serum interleukin-6, total oxidant status, lipid hydroperoxide, and malondialdehyde and increased superoxide dismutase (P<0.001 for all), whereas there was no significant change in C-reactive protein and tumor necrosis factor-alpha levels. CONCLUSION: In this trial, we demonstrated that a pistachio diet improved blood glucose level, endothelial function, and some indices of inflammation and oxidative status in healthy young men. These findings are in accordance with the idea that nuts, in particular pistachio nuts, have favorable effects beyond lipid lowering that deserve to be evaluated with prospective follow-up studies. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19647416/Effect_of_pistachio_diet_on_lipid_parameters_endothelial_function_inflammation_and_oxidative_status:_a_prospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(09)00247-0 DB - PRIME DP - Unbound Medicine ER -