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Efficacy of coumarin on hepatic key enzymes of glucose metabolism in chemical induced type 2 diabetic rats.
Chem Biol Interact. 2009 Oct 30; 181(3):292-6.CB

Abstract

The study was undertaken to evaluate the antidiabetic effect of coumarin on carbohydrate metabolic key enzymes in control and streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. On oral administration of coumarin at a dose of 100mg/kg body weight per day to diabetic rats for 45 days; resulted in a significant reduction in the levels of plasma glucose, glycosylated hemoglobin (HbA(1)c) and increase in the levels of insulin and hemoglobin. Administration of coumarin caused a significant increase in the levels of glycolytic enzyme (hexokinase) and hepatic shunt enzyme (glucose-6-phophate dehydrogenase) whereas significant decrease in the levels of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. This study indicates that the administration of coumarin to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India. paribalaji@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19647726

Citation

Pari, Leelavinothan, and Narayanasamy Rajarajeswari. "Efficacy of Coumarin On Hepatic Key Enzymes of Glucose Metabolism in Chemical Induced Type 2 Diabetic Rats." Chemico-biological Interactions, vol. 181, no. 3, 2009, pp. 292-6.
Pari L, Rajarajeswari N. Efficacy of coumarin on hepatic key enzymes of glucose metabolism in chemical induced type 2 diabetic rats. Chem Biol Interact. 2009;181(3):292-6.
Pari, L., & Rajarajeswari, N. (2009). Efficacy of coumarin on hepatic key enzymes of glucose metabolism in chemical induced type 2 diabetic rats. Chemico-biological Interactions, 181(3), 292-6. https://doi.org/10.1016/j.cbi.2009.07.018
Pari L, Rajarajeswari N. Efficacy of Coumarin On Hepatic Key Enzymes of Glucose Metabolism in Chemical Induced Type 2 Diabetic Rats. Chem Biol Interact. 2009 Oct 30;181(3):292-6. PubMed PMID: 19647726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of coumarin on hepatic key enzymes of glucose metabolism in chemical induced type 2 diabetic rats. AU - Pari,Leelavinothan, AU - Rajarajeswari,Narayanasamy, Y1 - 2009/08/06/ PY - 2009/04/29/received PY - 2009/07/23/revised PY - 2009/07/24/accepted PY - 2009/8/4/entrez PY - 2009/8/4/pubmed PY - 2009/11/11/medline SP - 292 EP - 6 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 181 IS - 3 N2 - The study was undertaken to evaluate the antidiabetic effect of coumarin on carbohydrate metabolic key enzymes in control and streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. On oral administration of coumarin at a dose of 100mg/kg body weight per day to diabetic rats for 45 days; resulted in a significant reduction in the levels of plasma glucose, glycosylated hemoglobin (HbA(1)c) and increase in the levels of insulin and hemoglobin. Administration of coumarin caused a significant increase in the levels of glycolytic enzyme (hexokinase) and hepatic shunt enzyme (glucose-6-phophate dehydrogenase) whereas significant decrease in the levels of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. This study indicates that the administration of coumarin to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/19647726/Efficacy_of_coumarin_on_hepatic_key_enzymes_of_glucose_metabolism_in_chemical_induced_type_2_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -