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Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice.
J Dermatol Sci. 2009 Oct; 56(1):37-42.JD

Abstract

BACKGROUND

Increasing evidence suggests that stress can trigger and exacerbate atopic dermatitis (AD). Psychotherapy is becoming more important in the treatment of AD patients. Yokukansan (YKS, Yi-Gan San in Chinese), a traditional Japanese medicine, has been widely utilized in the treatment of neurosis, insomnia and anxiety especially in Asian countries. Furthermore, it was reported that YKS inhibited skin lesions in socially isolated mice but not in group-housed mice. Therefore, in the present study it was investigated whether or not YKS was effective in the treatment of AD using socially isolated NC/Nga mice.

OBJECTIVE

The present study was designed to assess the effect of YKS on the development of AD-like lesions in socially isolated NC/Nga mice to obtain information about its usefulness in the treatment of AD.

METHODS

Ten-week-old male NC/Nga mice were socially isolated under conventional conditions. YKS was administered orally to mice at the dose of 0.5% or 1.0% together with diet. The efficacy of YKS was evaluated by assessing skin lesion severity, scratching behaviors, skin hydration, and infiltration of inflammatory cells in the skin. Grooming behaviors evoked by social isolation stress and serum corticosterone levels were also measured.

RESULTS

Oral administration of YKS to socially isolated NC/Nga mice resulted in the inhibition of exacerbation of AD-like skin lesions. It seemed that the inhibition of exacerbation of AD-like skin lesions observed in NC/Nga mice might be due to suppression of the scratching and grooming behaviors, inhibition of the infiltration of mast cells and eosinophils, and retention of humidity in the skin. Serum corticosterone levels were also significantly inhibited in the 1%-YKS-treated mice as compared with those of the control mice. There were no significant differences in the levels of serum total IgE and nerve growth factor (NGF) between the YKS-treated mice and the non-treated control mice.

CONCLUSION

YKS inhibited the development of AD-like skin lesions in socially isolated NC/Nga mice by suppressing scratching and infiltration of inflammatory cells in the skin. These results indicate that YKS possesses an anti-itching property, and its anti-itching may be partly through attenuation on social isolation stress. It is expected that YKS might provide an effective alternative therapy for AD in human patients.

Authors+Show Affiliations

Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421 Tokyo, Japan. jiangju@juntendo.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19647983

Citation

Jiang, Ju, et al. "Oral Administration of Yokukansan Inhibits the Development of Atopic Dermatitis-like Lesions in Isolated NC/Nga Mice." Journal of Dermatological Science, vol. 56, no. 1, 2009, pp. 37-42.
Jiang J, Yamaguchi T, Funakushi N, et al. Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. J Dermatol Sci. 2009;56(1):37-42.
Jiang, J., Yamaguchi, T., Funakushi, N., Kuhara, T., Fan, P. S., Ueki, R., Suto, H., Kase, Y., Ikeda, S., & Ogawa, H. (2009). Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. Journal of Dermatological Science, 56(1), 37-42. https://doi.org/10.1016/j.jdermsci.2009.07.003
Jiang J, et al. Oral Administration of Yokukansan Inhibits the Development of Atopic Dermatitis-like Lesions in Isolated NC/Nga Mice. J Dermatol Sci. 2009;56(1):37-42. PubMed PMID: 19647983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. AU - Jiang,Ju, AU - Yamaguchi,Takuji, AU - Funakushi,Naoko, AU - Kuhara,Takatoshi, AU - Fan,Ping-shen, AU - Ueki,Rie, AU - Suto,Hajime, AU - Kase,Yoshio, AU - Ikeda,Shigaku, AU - Ogawa,Hideoki, Y1 - 2009/08/03/ PY - 2009/02/11/received PY - 2009/07/01/revised PY - 2009/07/03/accepted PY - 2009/8/4/entrez PY - 2009/8/4/pubmed PY - 2009/11/3/medline SP - 37 EP - 42 JF - Journal of dermatological science JO - J Dermatol Sci VL - 56 IS - 1 N2 - BACKGROUND: Increasing evidence suggests that stress can trigger and exacerbate atopic dermatitis (AD). Psychotherapy is becoming more important in the treatment of AD patients. Yokukansan (YKS, Yi-Gan San in Chinese), a traditional Japanese medicine, has been widely utilized in the treatment of neurosis, insomnia and anxiety especially in Asian countries. Furthermore, it was reported that YKS inhibited skin lesions in socially isolated mice but not in group-housed mice. Therefore, in the present study it was investigated whether or not YKS was effective in the treatment of AD using socially isolated NC/Nga mice. OBJECTIVE: The present study was designed to assess the effect of YKS on the development of AD-like lesions in socially isolated NC/Nga mice to obtain information about its usefulness in the treatment of AD. METHODS: Ten-week-old male NC/Nga mice were socially isolated under conventional conditions. YKS was administered orally to mice at the dose of 0.5% or 1.0% together with diet. The efficacy of YKS was evaluated by assessing skin lesion severity, scratching behaviors, skin hydration, and infiltration of inflammatory cells in the skin. Grooming behaviors evoked by social isolation stress and serum corticosterone levels were also measured. RESULTS: Oral administration of YKS to socially isolated NC/Nga mice resulted in the inhibition of exacerbation of AD-like skin lesions. It seemed that the inhibition of exacerbation of AD-like skin lesions observed in NC/Nga mice might be due to suppression of the scratching and grooming behaviors, inhibition of the infiltration of mast cells and eosinophils, and retention of humidity in the skin. Serum corticosterone levels were also significantly inhibited in the 1%-YKS-treated mice as compared with those of the control mice. There were no significant differences in the levels of serum total IgE and nerve growth factor (NGF) between the YKS-treated mice and the non-treated control mice. CONCLUSION: YKS inhibited the development of AD-like skin lesions in socially isolated NC/Nga mice by suppressing scratching and infiltration of inflammatory cells in the skin. These results indicate that YKS possesses an anti-itching property, and its anti-itching may be partly through attenuation on social isolation stress. It is expected that YKS might provide an effective alternative therapy for AD in human patients. SN - 1873-569X UR - https://www.unboundmedicine.com/medline/citation/19647983/Oral_administration_of_Yokukansan_inhibits_the_development_of_atopic_dermatitis_like_lesions_in_isolated_NC/Nga_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-1811(09)00199-6 DB - PRIME DP - Unbound Medicine ER -