Tags

Type your tag names separated by a space and hit enter

Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required.
Acta Anaesthesiol Scand. 2009 Oct; 53(9):1214-20.AA

Abstract

BACKGROUND

We carried out this prospective, randomized, double-blind study in order to evaluate whether the intrathecal addition of sufentanil 3.3 mcg affects both the minimum local anaesthetic dose (MLAD) of spinal levobupivacaine and ropivacaine for a caesarean section and enhances the spinal block characteristics.

METHODS

One hundred and eighty women were randomly allocated into four groups: levobupivacaine (Group L), levobupivacaine plus sufentanil (Group L+S), ropivacaine (Group R) and ropivacaine plus sufentanil (Group R+S). Each received 3 ml of the study solution intrathecally as part of a combined spinal/epidural technique. The initial dose was 12 mg for Groups L and L+S, and 15 mg for Groups R and R+S. The test solution was required to achieve a visual analogue pain score (VAPS) of 30 mm or less to be considered effective at skin incision, uterine incision, birth, peritoneal closure and at the conclusion of surgery. Effective or ineffective responses determined a 0.5 mg decrease or increase of the same drug, respectively, for the next patient in the same group, using an up-down sequential allocation.

RESULTS

Using the Dixon and Massey formula, the MLAD was 10.65 mg [confidence interval (CI) 95%: 10.14-11.56] in Group L, 4.73 mg (CI 95%: 4.39-5.07) in Group L+S, 14.12 mg (CI 95%: 13.50-14.60) in Group R and 6.44 mg (CI 95%: 5.86-7.02) in Group R+S.

CONCLUSIONS

The addition of sufentanil reduced the MLAD of both the local anaesthetics. It did not affect their potency ratio significantly and resulted in enhanced spinal anaesthesia.

Authors+Show Affiliations

Department of Anaesthesia and Intensive Care, Fatebenefratelli General Hospital, 00186 Rome, Italy. rparpaglioni@email.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19650807

Citation

Parpaglioni, R, et al. "Adding Sufentanil to Levobupivacaine or Ropivacaine Intrathecal Anaesthesia Affects the Minimum Local Anaesthetic Dose Required." Acta Anaesthesiologica Scandinavica, vol. 53, no. 9, 2009, pp. 1214-20.
Parpaglioni R, Baldassini B, Barbati G, et al. Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required. Acta Anaesthesiol Scand. 2009;53(9):1214-20.
Parpaglioni, R., Baldassini, B., Barbati, G., & Celleno, D. (2009). Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required. Acta Anaesthesiologica Scandinavica, 53(9), 1214-20. https://doi.org/10.1111/j.1399-6576.2009.02033.x
Parpaglioni R, et al. Adding Sufentanil to Levobupivacaine or Ropivacaine Intrathecal Anaesthesia Affects the Minimum Local Anaesthetic Dose Required. Acta Anaesthesiol Scand. 2009;53(9):1214-20. PubMed PMID: 19650807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required. AU - Parpaglioni,R, AU - Baldassini,B, AU - Barbati,G, AU - Celleno,D, Y1 - 2009/07/22/ PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2009/11/18/medline SP - 1214 EP - 20 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 53 IS - 9 N2 - BACKGROUND: We carried out this prospective, randomized, double-blind study in order to evaluate whether the intrathecal addition of sufentanil 3.3 mcg affects both the minimum local anaesthetic dose (MLAD) of spinal levobupivacaine and ropivacaine for a caesarean section and enhances the spinal block characteristics. METHODS: One hundred and eighty women were randomly allocated into four groups: levobupivacaine (Group L), levobupivacaine plus sufentanil (Group L+S), ropivacaine (Group R) and ropivacaine plus sufentanil (Group R+S). Each received 3 ml of the study solution intrathecally as part of a combined spinal/epidural technique. The initial dose was 12 mg for Groups L and L+S, and 15 mg for Groups R and R+S. The test solution was required to achieve a visual analogue pain score (VAPS) of 30 mm or less to be considered effective at skin incision, uterine incision, birth, peritoneal closure and at the conclusion of surgery. Effective or ineffective responses determined a 0.5 mg decrease or increase of the same drug, respectively, for the next patient in the same group, using an up-down sequential allocation. RESULTS: Using the Dixon and Massey formula, the MLAD was 10.65 mg [confidence interval (CI) 95%: 10.14-11.56] in Group L, 4.73 mg (CI 95%: 4.39-5.07) in Group L+S, 14.12 mg (CI 95%: 13.50-14.60) in Group R and 6.44 mg (CI 95%: 5.86-7.02) in Group R+S. CONCLUSIONS: The addition of sufentanil reduced the MLAD of both the local anaesthetics. It did not affect their potency ratio significantly and resulted in enhanced spinal anaesthesia. SN - 1399-6576 UR - https://www.unboundmedicine.com/medline/citation/19650807/Adding_sufentanil_to_levobupivacaine_or_ropivacaine_intrathecal_anaesthesia_affects_the_minimum_local_anaesthetic_dose_required_ L2 - https://doi.org/10.1111/j.1399-6576.2009.02033.x DB - PRIME DP - Unbound Medicine ER -