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Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats.
Fundam Clin Pharmacol 2009; 23(6):757-65FC

Abstract

Carvacrol (2-methyl-5-(1-methylethyl)-phenol) is a predominant monoterpenic phenol which occurs in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus, and Corydothymus species. This study was designed to investigate the hepatoprotective and antioxidant properties of carvacrol on D-galactosamine (D-GalN)-induced hepatotoxicity and oxidative damage in male albino Wistar rats. D-GalN hepatotoxic rats exhibited elevation in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, and lipidperoxidative markers such as thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides. Activities of enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase) and the levels of non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma, erythrocytes, liver, and kidney decreased in the hepatotoxic rats. Oral administration of carvacrol for 21 days brought these parameters towards normal. The biochemical observations were supported by histological studies of rat liver and kidney tissues. These results suggest that carvacrol could afford a significant hepatoprotective and antioxidant effect against D-GalN-induced rats.

Authors+Show Affiliations

Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University, Riyadh, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19650854

Citation

Aristatile, Balakrishnan, et al. "Effect of Carvacrol On Hepatic Marker Enzymes and Antioxidant Status in D-galactosamine-induced Hepatotoxicity in Rats." Fundamental & Clinical Pharmacology, vol. 23, no. 6, 2009, pp. 757-65.
Aristatile B, Al-Numair KS, Veeramani C, et al. Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. Fundam Clin Pharmacol. 2009;23(6):757-65.
Aristatile, B., Al-Numair, K. S., Veeramani, C., & Pugalendi, K. V. (2009). Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. Fundamental & Clinical Pharmacology, 23(6), pp. 757-65. doi:10.1111/j.1472-8206.2009.00721.x.
Aristatile B, et al. Effect of Carvacrol On Hepatic Marker Enzymes and Antioxidant Status in D-galactosamine-induced Hepatotoxicity in Rats. Fundam Clin Pharmacol. 2009;23(6):757-65. PubMed PMID: 19650854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. AU - Aristatile,Balakrishnan, AU - Al-Numair,Khalid S, AU - Veeramani,Chinnadurai, AU - Pugalendi,Kodukkur Viswanathan, Y1 - 2009/07/24/ PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2010/2/5/medline SP - 757 EP - 65 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 23 IS - 6 N2 - Carvacrol (2-methyl-5-(1-methylethyl)-phenol) is a predominant monoterpenic phenol which occurs in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus, and Corydothymus species. This study was designed to investigate the hepatoprotective and antioxidant properties of carvacrol on D-galactosamine (D-GalN)-induced hepatotoxicity and oxidative damage in male albino Wistar rats. D-GalN hepatotoxic rats exhibited elevation in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, and lipidperoxidative markers such as thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides. Activities of enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase) and the levels of non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma, erythrocytes, liver, and kidney decreased in the hepatotoxic rats. Oral administration of carvacrol for 21 days brought these parameters towards normal. The biochemical observations were supported by histological studies of rat liver and kidney tissues. These results suggest that carvacrol could afford a significant hepatoprotective and antioxidant effect against D-GalN-induced rats. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/19650854/Effect_of_carvacrol_on_hepatic_marker_enzymes_and_antioxidant_status_in_D_galactosamine_induced_hepatotoxicity_in_rats_ L2 - https://doi.org/10.1111/j.1472-8206.2009.00721.x DB - PRIME DP - Unbound Medicine ER -