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Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats.

Abstract

Carvacrol (2-methyl-5-(1-methylethyl)-phenol) is a predominant monoterpenic phenol which occurs in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus, and Corydothymus species. This study was designed to investigate the hepatoprotective and antioxidant properties of carvacrol on D-galactosamine (D-GalN)-induced hepatotoxicity and oxidative damage in male albino Wistar rats. D-GalN hepatotoxic rats exhibited elevation in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, and lipidperoxidative markers such as thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides. Activities of enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase) and the levels of non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma, erythrocytes, liver, and kidney decreased in the hepatotoxic rats. Oral administration of carvacrol for 21 days brought these parameters towards normal. The biochemical observations were supported by histological studies of rat liver and kidney tissues. These results suggest that carvacrol could afford a significant hepatoprotective and antioxidant effect against D-GalN-induced rats.

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  • Authors+Show Affiliations

    ,

    Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University, Riyadh, Saudi Arabia.

    , ,

    Source

    Fundamental & clinical pharmacology 23:6 2009 Dec pg 757-65

    MeSH

    Alanine Transaminase
    Alkaline Phosphatase
    Animals
    Antioxidants
    Aspartate Aminotransferases
    Biomarkers
    Chemical and Drug Induced Liver Injury
    Galactosamine
    Glutathione Peroxidase
    Kidney
    Lipid Peroxidation
    Liver
    Male
    Monoterpenes
    Oxidative Stress
    Rats
    Rats, Wistar
    Silymarin
    Superoxide Dismutase
    Thiobarbituric Acid Reactive Substances
    gamma-Glutamyltransferase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19650854

    Citation

    Aristatile, Balakrishnan, et al. "Effect of Carvacrol On Hepatic Marker Enzymes and Antioxidant Status in D-galactosamine-induced Hepatotoxicity in Rats." Fundamental & Clinical Pharmacology, vol. 23, no. 6, 2009, pp. 757-65.
    Aristatile B, Al-Numair KS, Veeramani C, et al. Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. Fundam Clin Pharmacol. 2009;23(6):757-65.
    Aristatile, B., Al-Numair, K. S., Veeramani, C., & Pugalendi, K. V. (2009). Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. Fundamental & Clinical Pharmacology, 23(6), pp. 757-65. doi:10.1111/j.1472-8206.2009.00721.x.
    Aristatile B, et al. Effect of Carvacrol On Hepatic Marker Enzymes and Antioxidant Status in D-galactosamine-induced Hepatotoxicity in Rats. Fundam Clin Pharmacol. 2009;23(6):757-65. PubMed PMID: 19650854.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. AU - Aristatile,Balakrishnan, AU - Al-Numair,Khalid S, AU - Veeramani,Chinnadurai, AU - Pugalendi,Kodukkur Viswanathan, Y1 - 2009/07/24/ PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2010/2/5/medline SP - 757 EP - 65 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 23 IS - 6 N2 - Carvacrol (2-methyl-5-(1-methylethyl)-phenol) is a predominant monoterpenic phenol which occurs in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus, and Corydothymus species. This study was designed to investigate the hepatoprotective and antioxidant properties of carvacrol on D-galactosamine (D-GalN)-induced hepatotoxicity and oxidative damage in male albino Wistar rats. D-GalN hepatotoxic rats exhibited elevation in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, and lipidperoxidative markers such as thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides. Activities of enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase) and the levels of non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma, erythrocytes, liver, and kidney decreased in the hepatotoxic rats. Oral administration of carvacrol for 21 days brought these parameters towards normal. The biochemical observations were supported by histological studies of rat liver and kidney tissues. These results suggest that carvacrol could afford a significant hepatoprotective and antioxidant effect against D-GalN-induced rats. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/19650854/Effect_of_carvacrol_on_hepatic_marker_enzymes_and_antioxidant_status_in_D_galactosamine_induced_hepatotoxicity_in_rats_ L2 - https://doi.org/10.1111/j.1472-8206.2009.00721.x DB - PRIME DP - Unbound Medicine ER -