Tags

Type your tag names separated by a space and hit enter

Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells.
Cancer Sci. 2009 Oct; 100(10):1963-70.CS

Abstract

The polyphenol epigallocatechin-3 gallate (EGCG) in green tea suppresses tumor growth by direct action on tumor cells and by inhibition of angiogenesis, but it is not known whether it specifically inhibits tumor angiogenesis. We examined the anti-angiogenic effect of EGCG on tumor-associated endothelial cells (TEC), endothelial progenitor cells (EPC), and normal endothelial cells (NEC). EGCG suppressed the migration of TEC and EPC but not NEC. EGCG also inhibited the phosphorylation of Akt in TEC but not in NEC. Furthermore, vascular endothelial growth factor-induced mobilization of EPC into circulation was inhibited by EGCG. MMP-9 in the bone marrow plasma plays key roles in EPC mobilization into circulation. We observed that expression of MMP-9 mRNA was downregulated by EGCG in mouse bone marrow stromal cells. In an in vivo model, EGCG suppressed growth of melanoma and reduced microvessel density. Our study showed that EGCG has selective anti-angiogenic effects on TEC and EPC. It is suggested that EGCG could be a promising angiogenesis inhibitor for cancer therapy.

Authors+Show Affiliations

Department of Oral Pathology and Biology, Division of Oral Pathological Science, University of Hokkaido, Sapporo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19650861

Citation

Ohga, Noritaka, et al. "Inhibitory Effects of Epigallocatechin-3 Gallate, a Polyphenol in Green Tea, On Tumor-associated Endothelial Cells and Endothelial Progenitor Cells." Cancer Science, vol. 100, no. 10, 2009, pp. 1963-70.
Ohga N, Hida K, Hida Y, et al. Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells. Cancer Sci. 2009;100(10):1963-70.
Ohga, N., Hida, K., Hida, Y., Muraki, C., Tsuchiya, K., Matsuda, K., Ohiro, Y., Totsuka, Y., & Shindoh, M. (2009). Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells. Cancer Science, 100(10), 1963-70. https://doi.org/10.1111/j.1349-7006.2009.01255.x
Ohga N, et al. Inhibitory Effects of Epigallocatechin-3 Gallate, a Polyphenol in Green Tea, On Tumor-associated Endothelial Cells and Endothelial Progenitor Cells. Cancer Sci. 2009;100(10):1963-70. PubMed PMID: 19650861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells. AU - Ohga,Noritaka, AU - Hida,Kyoko, AU - Hida,Yasuhiro, AU - Muraki,Chikara, AU - Tsuchiya,Kunihiko, AU - Matsuda,Kohei, AU - Ohiro,Yoichi, AU - Totsuka,Yasunori, AU - Shindoh,Masanobu, Y1 - 2009/07/23/ PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2009/10/10/medline SP - 1963 EP - 70 JF - Cancer science JO - Cancer Sci VL - 100 IS - 10 N2 - The polyphenol epigallocatechin-3 gallate (EGCG) in green tea suppresses tumor growth by direct action on tumor cells and by inhibition of angiogenesis, but it is not known whether it specifically inhibits tumor angiogenesis. We examined the anti-angiogenic effect of EGCG on tumor-associated endothelial cells (TEC), endothelial progenitor cells (EPC), and normal endothelial cells (NEC). EGCG suppressed the migration of TEC and EPC but not NEC. EGCG also inhibited the phosphorylation of Akt in TEC but not in NEC. Furthermore, vascular endothelial growth factor-induced mobilization of EPC into circulation was inhibited by EGCG. MMP-9 in the bone marrow plasma plays key roles in EPC mobilization into circulation. We observed that expression of MMP-9 mRNA was downregulated by EGCG in mouse bone marrow stromal cells. In an in vivo model, EGCG suppressed growth of melanoma and reduced microvessel density. Our study showed that EGCG has selective anti-angiogenic effects on TEC and EPC. It is suggested that EGCG could be a promising angiogenesis inhibitor for cancer therapy. SN - 1349-7006 UR - https://www.unboundmedicine.com/medline/citation/19650861/Inhibitory_effects_of_epigallocatechin_3_gallate_a_polyphenol_in_green_tea_on_tumor_associated_endothelial_cells_and_endothelial_progenitor_cells_ L2 - https://doi.org/10.1111/j.1349-7006.2009.01255.x DB - PRIME DP - Unbound Medicine ER -