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The association of biomarkers of iron status with peripheral arterial disease in US adults.

Abstract

BACKGROUND

Several studies have examined the association of biomarkers of iron metabolism with measures of carotid artery atherosclerosis, with inconsistent results. Few studies, however, have evaluated the association between biomarkers of iron metabolism and peripheral arterial disease (PAD). The purpose of this study is to examine the association of ferritin and transferrin saturation with PAD.

METHODS

Serum ferritin, transferrin saturation, and PAD, defined as having an ankle-brachial blood pressure index <0.9, were measured in 1,631 men and 1,031 postmenopausal women participating in the 19992002 National Health and Nutrition Examination Survey (NHANES).

RESULTS

The multivariable adjusted odds ratios (95% confidence interval) for PAD associated with a two-fold increase in serum ferritin and transferrin saturation were 1.18 (1.001.41) and 1.45 (0.832.51), respectively, for men and 1.04 (0.871.25) and 1.55 (0.982.45), respectively, for women. After stratifying by cholesterol levels, the multivariable adjusted odds ratios (95% confidence intervals) for PAD associated with a two-fold increase in ferritin and transferrin saturation was 1.04 (0.781.39) and 0.73 (0.351.50), respectively, for men with total cholesterol <200 mg/dL and 1.30 (0.991.72) and 2.59 (0.996.78), respectively, for men with total cholesterol >or= 200 mg/dL (p-value for interaction was 0.58 for ferritin and 0.08 for transferrin saturation). After stratifying by cholesterol levels, the multivariable adjusted odds ratios (95% confidence intervals) for PAD associated with a two-fold increase in ferritin and transferrin saturation was 0.66 (0.411.05) and 0.75 (0.441.28), respectively, for women with total cholesterol <200 mg/dL, and 1.20 (0.951.51) and 2.07 (1.014.22), respectively, for women with total cholesterol >or= 200 mg/dL (p-value for interaction was 0.05 for ferritin and 0.02 for transferrin saturation).

CONCLUSION

In this large nationally representative sample of men and postmenopausal women, we found a modest association of ferritin and transferrin saturation with PAD, particularly among those with high cholesterol levels.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. amenke@jhsph.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19650928

Citation

Menke, Andy, et al. "The Association of Biomarkers of Iron Status With Peripheral Arterial Disease in US Adults." BMC Cardiovascular Disorders, vol. 9, 2009, p. 34.
Menke A, Fernández-Real JM, Muntner P, et al. The association of biomarkers of iron status with peripheral arterial disease in US adults. BMC Cardiovasc Disord. 2009;9:34.
Menke, A., Fernández-Real, J. M., Muntner, P., & Guallar, E. (2009). The association of biomarkers of iron status with peripheral arterial disease in US adults. BMC Cardiovascular Disorders, 9, p. 34. doi:10.1186/1471-2261-9-34.
Menke A, et al. The Association of Biomarkers of Iron Status With Peripheral Arterial Disease in US Adults. BMC Cardiovasc Disord. 2009 Aug 3;9:34. PubMed PMID: 19650928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of biomarkers of iron status with peripheral arterial disease in US adults. AU - Menke,Andy, AU - Fernández-Real,José Manuel, AU - Muntner,Paul, AU - Guallar,Eliseo, Y1 - 2009/08/03/ PY - 2009/02/23/received PY - 2009/08/03/accepted PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2009/9/25/medline SP - 34 EP - 34 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 9 N2 - BACKGROUND: Several studies have examined the association of biomarkers of iron metabolism with measures of carotid artery atherosclerosis, with inconsistent results. Few studies, however, have evaluated the association between biomarkers of iron metabolism and peripheral arterial disease (PAD). The purpose of this study is to examine the association of ferritin and transferrin saturation with PAD. METHODS: Serum ferritin, transferrin saturation, and PAD, defined as having an ankle-brachial blood pressure index <0.9, were measured in 1,631 men and 1,031 postmenopausal women participating in the 19992002 National Health and Nutrition Examination Survey (NHANES). RESULTS: The multivariable adjusted odds ratios (95% confidence interval) for PAD associated with a two-fold increase in serum ferritin and transferrin saturation were 1.18 (1.001.41) and 1.45 (0.832.51), respectively, for men and 1.04 (0.871.25) and 1.55 (0.982.45), respectively, for women. After stratifying by cholesterol levels, the multivariable adjusted odds ratios (95% confidence intervals) for PAD associated with a two-fold increase in ferritin and transferrin saturation was 1.04 (0.781.39) and 0.73 (0.351.50), respectively, for men with total cholesterol <200 mg/dL and 1.30 (0.991.72) and 2.59 (0.996.78), respectively, for men with total cholesterol >or= 200 mg/dL (p-value for interaction was 0.58 for ferritin and 0.08 for transferrin saturation). After stratifying by cholesterol levels, the multivariable adjusted odds ratios (95% confidence intervals) for PAD associated with a two-fold increase in ferritin and transferrin saturation was 0.66 (0.411.05) and 0.75 (0.441.28), respectively, for women with total cholesterol <200 mg/dL, and 1.20 (0.951.51) and 2.07 (1.014.22), respectively, for women with total cholesterol >or= 200 mg/dL (p-value for interaction was 0.05 for ferritin and 0.02 for transferrin saturation). CONCLUSION: In this large nationally representative sample of men and postmenopausal women, we found a modest association of ferritin and transferrin saturation with PAD, particularly among those with high cholesterol levels. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/19650928/The_association_of_biomarkers_of_iron_status_with_peripheral_arterial_disease_in_US_adults_ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-9-34 DB - PRIME DP - Unbound Medicine ER -