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Long-term intake of a high zinc diet causes iron deficiency anemia accompanied by reticulocytosis and extra-medullary erythropoiesis.
Toxicol Lett 2009; 191(1):15-9TL

Abstract

To elucidate the pathophysiology of zinc (Zn)-induced iron (Fe) deficiency anemia (IDA), we examined hemoglobin (Hb) concentrations, hematocrit (Ht) levels, numbers of circulating red blood cells (RBC) and reticulocytes, values of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC), serum Zn, Fe and erythropoietin (EPO) concentrations and histopathological changes in the bone marrow, spleen and liver using rats fed with a standard or high Zn diet for 20 weeks. Rats fed with the high Zn diet exhibited a significant decrease in Hb concentrations, Ht levels and MCV, MCH and MCHC values, indicating microcytic hypochromic anemia characterized by Fe deficiency. Also, a marked decrease in serum Fe concentrations was seen in rats fed with the high Zn diet relative to rats fed with the standard diet. Interestingly, the number of RBC was comparable in both groups of rats, although a decrease in the number of RBC is ordinarily seen in IDA. There were reticulocytosis and extra-medullary erythropoiesis in the spleen and an increase in serum EPO concentrations in rats fed with the high Zn diet vs. those on the standard diet. These observations suggest that both reticulocytosis and extra-medullary erythropoiesis in the spleen played a role in maintaining the number of RBC in rats fed with the high Zn diet, preventing further progression of anemia. Further, increased production of EPO may be involved in the induction of reticulocytosis and extra-medullary erythropoiesis in the spleen.

Authors+Show Affiliations

Department of Public Health and Environmental Medicine, Faculty of Medicine, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, Japan. hryanagisawa@jikei.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19651194

Citation

Yanagisawa, Hiroyuki, et al. "Long-term Intake of a High Zinc Diet Causes Iron Deficiency Anemia Accompanied By Reticulocytosis and Extra-medullary Erythropoiesis." Toxicology Letters, vol. 191, no. 1, 2009, pp. 15-9.
Yanagisawa H, Miyakoshi Y, Kobayashi K, et al. Long-term intake of a high zinc diet causes iron deficiency anemia accompanied by reticulocytosis and extra-medullary erythropoiesis. Toxicol Lett. 2009;191(1):15-9.
Yanagisawa, H., Miyakoshi, Y., Kobayashi, K., Sakae, K., Kawasaki, I., Suzuki, Y., & Tamura, J. (2009). Long-term intake of a high zinc diet causes iron deficiency anemia accompanied by reticulocytosis and extra-medullary erythropoiesis. Toxicology Letters, 191(1), pp. 15-9. doi:10.1016/j.toxlet.2009.07.024.
Yanagisawa H, et al. Long-term Intake of a High Zinc Diet Causes Iron Deficiency Anemia Accompanied By Reticulocytosis and Extra-medullary Erythropoiesis. Toxicol Lett. 2009 Dec 1;191(1):15-9. PubMed PMID: 19651194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term intake of a high zinc diet causes iron deficiency anemia accompanied by reticulocytosis and extra-medullary erythropoiesis. AU - Yanagisawa,Hiroyuki, AU - Miyakoshi,Yuichi, AU - Kobayashi,Koh, AU - Sakae,Kensaku, AU - Kawasaki,Ichiro, AU - Suzuki,Yuji, AU - Tamura,Jun'ichi, Y1 - 2009/08/03/ PY - 2009/04/02/received PY - 2009/07/24/revised PY - 2009/07/25/accepted PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2009/12/16/medline SP - 15 EP - 9 JF - Toxicology letters JO - Toxicol. Lett. VL - 191 IS - 1 N2 - To elucidate the pathophysiology of zinc (Zn)-induced iron (Fe) deficiency anemia (IDA), we examined hemoglobin (Hb) concentrations, hematocrit (Ht) levels, numbers of circulating red blood cells (RBC) and reticulocytes, values of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC), serum Zn, Fe and erythropoietin (EPO) concentrations and histopathological changes in the bone marrow, spleen and liver using rats fed with a standard or high Zn diet for 20 weeks. Rats fed with the high Zn diet exhibited a significant decrease in Hb concentrations, Ht levels and MCV, MCH and MCHC values, indicating microcytic hypochromic anemia characterized by Fe deficiency. Also, a marked decrease in serum Fe concentrations was seen in rats fed with the high Zn diet relative to rats fed with the standard diet. Interestingly, the number of RBC was comparable in both groups of rats, although a decrease in the number of RBC is ordinarily seen in IDA. There were reticulocytosis and extra-medullary erythropoiesis in the spleen and an increase in serum EPO concentrations in rats fed with the high Zn diet vs. those on the standard diet. These observations suggest that both reticulocytosis and extra-medullary erythropoiesis in the spleen played a role in maintaining the number of RBC in rats fed with the high Zn diet, preventing further progression of anemia. Further, increased production of EPO may be involved in the induction of reticulocytosis and extra-medullary erythropoiesis in the spleen. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/19651194/Long_term_intake_of_a_high_zinc_diet_causes_iron_deficiency_anemia_accompanied_by_reticulocytosis_and_extra_medullary_erythropoiesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(09)01366-6 DB - PRIME DP - Unbound Medicine ER -