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Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease.
Vasc Med. 2009 Aug; 14(3):215-20.VM

Abstract

Myeloperoxidase (MPO) is an enzymatic mediator of several inflammatory cascades and higher serum levels have been associated with increased risk of adverse cardiovascular events. We investigated the association of serum MPO with the ankle-brachial index (ABI) and peripheral arterial disease (PAD) in a bi-ethnic cohort of African-Americans and non-Hispanic white individuals. Participants included 1324 African-Americans (mean age 64 years, 71% women) and 1237 non-Hispanic white individuals (mean age 59 years, 57% women) belonging to hypertensive sibships. Serum levels of MPO were measured by solid phase sandwich immunoassay. ABI was measured using a standard protocol and PAD was defined as an ABI < 0.90. Multivariable regression analysis using generalized estimating equations were performed to assess whether serum MPO levels were associated with ABI and the presence of PAD. After adjustment for age and sex, higher MPO levels were significantly associated with lower ABI and the presence of PAD in African-Americans (p = 0.004 and p = 0.005, respectively) and in non-Hispanic white individuals (p = 0.001 and p = 0.016, respectively). After additional adjustment for conventional risk factors (diabetes, smoking status, total and high-density lipoprotein cholesterol, waist circumference, hypertension), prior history of myocardial infarction or stroke, and medication use (statins, aspirin, estrogen), higher MPO levels remained significantly associated with lower ABI and the presence of PAD in both African-Americans (p = 0.008 and p = 0.010, respectively) and non-Hispanic white individuals (p = 0.001 and p = 0.018, respectively). We conclude that higher MPO levels are associated with lower ABI and the presence of PAD in African-Americans and non-Hispanic white individuals.

Authors+Show Affiliations

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19651670

Citation

Ali, Zeenat, et al. "Association of Serum Myeloperoxidase With the Ankle-brachial Index and Peripheral Arterial Disease." Vascular Medicine (London, England), vol. 14, no. 3, 2009, pp. 215-20.
Ali Z, Sarcia P, Mosley TH, et al. Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease. Vasc Med. 2009;14(3):215-20.
Ali, Z., Sarcia, P., Mosley, T. H., Kondragunta, V., & Kullo, I. J. (2009). Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease. Vascular Medicine (London, England), 14(3), 215-20. https://doi.org/10.1177/1358863X08101999
Ali Z, et al. Association of Serum Myeloperoxidase With the Ankle-brachial Index and Peripheral Arterial Disease. Vasc Med. 2009;14(3):215-20. PubMed PMID: 19651670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease. AU - Ali,Zeenat, AU - Sarcia,Paul, AU - Mosley,Thomas H,Jr AU - Kondragunta,Venkateswarlu, AU - Kullo,Iftikhar J, PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2009/10/9/medline SP - 215 EP - 20 JF - Vascular medicine (London, England) JO - Vasc Med VL - 14 IS - 3 N2 - Myeloperoxidase (MPO) is an enzymatic mediator of several inflammatory cascades and higher serum levels have been associated with increased risk of adverse cardiovascular events. We investigated the association of serum MPO with the ankle-brachial index (ABI) and peripheral arterial disease (PAD) in a bi-ethnic cohort of African-Americans and non-Hispanic white individuals. Participants included 1324 African-Americans (mean age 64 years, 71% women) and 1237 non-Hispanic white individuals (mean age 59 years, 57% women) belonging to hypertensive sibships. Serum levels of MPO were measured by solid phase sandwich immunoassay. ABI was measured using a standard protocol and PAD was defined as an ABI < 0.90. Multivariable regression analysis using generalized estimating equations were performed to assess whether serum MPO levels were associated with ABI and the presence of PAD. After adjustment for age and sex, higher MPO levels were significantly associated with lower ABI and the presence of PAD in African-Americans (p = 0.004 and p = 0.005, respectively) and in non-Hispanic white individuals (p = 0.001 and p = 0.016, respectively). After additional adjustment for conventional risk factors (diabetes, smoking status, total and high-density lipoprotein cholesterol, waist circumference, hypertension), prior history of myocardial infarction or stroke, and medication use (statins, aspirin, estrogen), higher MPO levels remained significantly associated with lower ABI and the presence of PAD in both African-Americans (p = 0.008 and p = 0.010, respectively) and non-Hispanic white individuals (p = 0.001 and p = 0.018, respectively). We conclude that higher MPO levels are associated with lower ABI and the presence of PAD in African-Americans and non-Hispanic white individuals. SN - 1358-863X UR - https://www.unboundmedicine.com/medline/citation/19651670/Association_of_serum_myeloperoxidase_with_the_ankle_brachial_index_and_peripheral_arterial_disease_ L2 - http://journals.sagepub.com/doi/full/10.1177/1358863X08101999?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -