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Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults.
Intern Med. 2009; 48(15):1267-72.IM

Abstract

A 33-year-old Japanese man was referred to our hospital after a huge intrapelvic tumor with bilateral hydronephrosis was found following persistent lumbago. Natural killer/T-cell lymphoma was suspected due to positive immunostaining for CD56, but CHOP therapy was ineffective. Re-evaluation of the tumor cells showed that they were positive for CD99, neuron-specific enolase, and synaptophysin and had a t(11 ; 22) (q24 ; q12) translocation, leading to the revised diagnosis of primitive neuroectodermal tumor (PNET). Systemic chemotherapies and radiation therapy were added to surgical resection, and no recurrence has been detected for 3 years. Taken together, PNET may be considered in adult patients with CD56-positive tumors.

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Authors+Show Affiliations

Nagaya T
Department of Internal Medicine, Matsumoto Medical Center, Matsumoto.
Tanaka N
No affiliation info available
Kamijo A
No affiliation info available
Joshita S
No affiliation info available
Nakazawa K
No affiliation info available
Miyabayashi H
No affiliation info available
Yoneda S
No affiliation info available
Ito T
No affiliation info available
Komatsu M
No affiliation info available
Tanaka E
No affiliation info available
Kitano K
No affiliation info available

MeSH

AdultCD56 AntigenChromosomes, Human, Pair 11Chromosomes, Human, Pair 22Diagnosis, DifferentialHumansLymphoma, Extranodal NK-T-CellMaleNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionPelvic NeoplasmsProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSSarcoma, EwingStomach NeoplasmsTranslocation, Genetic

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19652428

Citation

Nagaya, Tadanobu, et al. "Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-positive Tumors in Adults." Internal Medicine (Tokyo, Japan), vol. 48, no. 15, 2009, pp. 1267-72.
Nagaya T, Tanaka N, Kamijo A, et al. Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults. Intern Med. 2009;48(15):1267-72.
Nagaya, T., Tanaka, N., Kamijo, A., Joshita, S., Nakazawa, K., Miyabayashi, H., Yoneda, S., Ito, T., Komatsu, M., Tanaka, E., & Kitano, K. (2009). Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults. Internal Medicine (Tokyo, Japan), 48(15), 1267-72.
Nagaya T, et al. Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-positive Tumors in Adults. Intern Med. 2009;48(15):1267-72. PubMed PMID: 19652428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults. AU - Nagaya,Tadanobu, AU - Tanaka,Naoki, AU - Kamijo,Atsushi, AU - Joshita,Satoru, AU - Nakazawa,Koh, AU - Miyabayashi,Hideharu, AU - Yoneda,Suguru, AU - Ito,Tetsuya, AU - Komatsu,Michiharu, AU - Tanaka,Eiji, AU - Kitano,Kiyoshi, Y1 - 2009/08/03/ PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2009/11/5/medline SP - 1267 EP - 72 JF - Internal medicine (Tokyo, Japan) JO - Intern Med VL - 48 IS - 15 N2 - A 33-year-old Japanese man was referred to our hospital after a huge intrapelvic tumor with bilateral hydronephrosis was found following persistent lumbago. Natural killer/T-cell lymphoma was suspected due to positive immunostaining for CD56, but CHOP therapy was ineffective. Re-evaluation of the tumor cells showed that they were positive for CD99, neuron-specific enolase, and synaptophysin and had a t(11 ; 22) (q24 ; q12) translocation, leading to the revised diagnosis of primitive neuroectodermal tumor (PNET). Systemic chemotherapies and radiation therapy were added to surgical resection, and no recurrence has been detected for 3 years. Taken together, PNET may be considered in adult patients with CD56-positive tumors. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/19652428/Primitive_neuroectodermal_tumor_as_a_differential_diagnosis_of_CD56_positive_tumors_in_adults_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/internalmedicine/48.1980?from=PubMed DB - PRIME DP - Unbound Medicine ER -