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Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults.
Intern Med. 2009; 48(15):1267-72.IM

Abstract

A 33-year-old Japanese man was referred to our hospital after a huge intrapelvic tumor with bilateral hydronephrosis was found following persistent lumbago. Natural killer/T-cell lymphoma was suspected due to positive immunostaining for CD56, but CHOP therapy was ineffective. Re-evaluation of the tumor cells showed that they were positive for CD99, neuron-specific enolase, and synaptophysin and had a t(11 ; 22) (q24 ; q12) translocation, leading to the revised diagnosis of primitive neuroectodermal tumor (PNET). Systemic chemotherapies and radiation therapy were added to surgical resection, and no recurrence has been detected for 3 years. Taken together, PNET may be considered in adult patients with CD56-positive tumors.

Authors+Show Affiliations

Department of Internal Medicine, Matsumoto Medical Center, Matsumoto.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19652428

Citation

Nagaya, Tadanobu, et al. "Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-positive Tumors in Adults." Internal Medicine (Tokyo, Japan), vol. 48, no. 15, 2009, pp. 1267-72.
Nagaya T, Tanaka N, Kamijo A, et al. Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults. Intern Med. 2009;48(15):1267-72.
Nagaya, T., Tanaka, N., Kamijo, A., Joshita, S., Nakazawa, K., Miyabayashi, H., Yoneda, S., Ito, T., Komatsu, M., Tanaka, E., & Kitano, K. (2009). Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults. Internal Medicine (Tokyo, Japan), 48(15), 1267-72.
Nagaya T, et al. Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-positive Tumors in Adults. Intern Med. 2009;48(15):1267-72. PubMed PMID: 19652428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primitive neuroectodermal tumor as a differential diagnosis of CD56-positive tumors in adults. AU - Nagaya,Tadanobu, AU - Tanaka,Naoki, AU - Kamijo,Atsushi, AU - Joshita,Satoru, AU - Nakazawa,Koh, AU - Miyabayashi,Hideharu, AU - Yoneda,Suguru, AU - Ito,Tetsuya, AU - Komatsu,Michiharu, AU - Tanaka,Eiji, AU - Kitano,Kiyoshi, Y1 - 2009/08/03/ PY - 2009/8/5/entrez PY - 2009/8/5/pubmed PY - 2009/11/5/medline SP - 1267 EP - 72 JF - Internal medicine (Tokyo, Japan) JO - Intern Med VL - 48 IS - 15 N2 - A 33-year-old Japanese man was referred to our hospital after a huge intrapelvic tumor with bilateral hydronephrosis was found following persistent lumbago. Natural killer/T-cell lymphoma was suspected due to positive immunostaining for CD56, but CHOP therapy was ineffective. Re-evaluation of the tumor cells showed that they were positive for CD99, neuron-specific enolase, and synaptophysin and had a t(11 ; 22) (q24 ; q12) translocation, leading to the revised diagnosis of primitive neuroectodermal tumor (PNET). Systemic chemotherapies and radiation therapy were added to surgical resection, and no recurrence has been detected for 3 years. Taken together, PNET may be considered in adult patients with CD56-positive tumors. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/19652428/Primitive_neuroectodermal_tumor_as_a_differential_diagnosis_of_CD56_positive_tumors_in_adults_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/internalmedicine/48.1980?from=PubMed DB - PRIME DP - Unbound Medicine ER -