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Mimivirus and its virophage.
Annu Rev Genet. 2009; 43:49-66.AR

Abstract

Mimivirus, a virus infecting amoebae of the acanthamoeba genus, is the prototype member of the Mimiviridae, the latest addition to the family of the nucleocytoplasmic large DNA viruses, already including the Poxviridae, the Iridoviridae, the Asfarviridae, and the Phycodnaviridae. Because of the size of its particle-a fiber-covered icosahedral protein capsid 0.75 microm in diameter-Mimivirus was initially mistaken for a parasitic bacterium. Its 1.2-Mb genome sequence encodes more than 900 proteins, many of them associated with functions never before encountered in a virus, such as four aminoacyl-tRNA synthetases. These findings revived the debate about the origin of DNA viruses and their possible role in the emergence of the eukaryotic nucleus. The recent isolation of a new type of satellite virus, called a virophage, associated with a second strain of Mimivirus, confirmed its unique position within the virus world. Post-genomic studies are now in progress, slowly shedding some light on the physiology of the most complex virus isolated to date.

Authors+Show Affiliations

Structural and Genomic Information Laboratory, CNRS-UPR 2589, IFR-88, Aix-Marseille University, Parc Scientifique de Luminy, Case 934, FR-13288 Marseille, France. jean-michel.claverie@igs.cnrs-mrs.frNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19653859

Citation

Claverie, Jean-Michel, and Chantal Abergel. "Mimivirus and Its Virophage." Annual Review of Genetics, vol. 43, 2009, pp. 49-66.
Claverie JM, Abergel C. Mimivirus and its virophage. Annu Rev Genet. 2009;43:49-66.
Claverie, J. M., & Abergel, C. (2009). Mimivirus and its virophage. Annual Review of Genetics, 43, 49-66. https://doi.org/10.1146/annurev-genet-102108-134255
Claverie JM, Abergel C. Mimivirus and Its Virophage. Annu Rev Genet. 2009;43:49-66. PubMed PMID: 19653859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mimivirus and its virophage. AU - Claverie,Jean-Michel, AU - Abergel,Chantal, PY - 2009/8/6/entrez PY - 2009/8/6/pubmed PY - 2009/12/16/medline SP - 49 EP - 66 JF - Annual review of genetics JO - Annu. Rev. Genet. VL - 43 N2 - Mimivirus, a virus infecting amoebae of the acanthamoeba genus, is the prototype member of the Mimiviridae, the latest addition to the family of the nucleocytoplasmic large DNA viruses, already including the Poxviridae, the Iridoviridae, the Asfarviridae, and the Phycodnaviridae. Because of the size of its particle-a fiber-covered icosahedral protein capsid 0.75 microm in diameter-Mimivirus was initially mistaken for a parasitic bacterium. Its 1.2-Mb genome sequence encodes more than 900 proteins, many of them associated with functions never before encountered in a virus, such as four aminoacyl-tRNA synthetases. These findings revived the debate about the origin of DNA viruses and their possible role in the emergence of the eukaryotic nucleus. The recent isolation of a new type of satellite virus, called a virophage, associated with a second strain of Mimivirus, confirmed its unique position within the virus world. Post-genomic studies are now in progress, slowly shedding some light on the physiology of the most complex virus isolated to date. SN - 1545-2948 UR - https://www.unboundmedicine.com/medline/citation/19653859/Mimivirus_and_its_virophage_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-genet-102108-134255?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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