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Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats.
Behav Pharmacol. 2009 Oct; 20(7):567-75.BP

Abstract

Oxidative stress plays a crucial role in the progression of cognitive decline in Alzheimer's disease (AD). Considerable attention has been focused on increasing the internal antioxidant defenses in response to AD. This study was designed to examine and compare the pretreatment effects of Pycnogenol (PYC) and vitamin E (Vit E) on cognitive deficits and oxidative damage in the hippocampus and cerebral cortex of intracerebroventricular streptozotocin (ICV-STZ)-infused rats. Rats pretreated with PYC (10 mg/kg), Vit E (100 mg/kg), and vehicle (intraperitoneal; once daily for 3 weeks) were bilaterally injected with ICV-STZ (3 mg/kg), whereas sham rats received the same volume of vehicle. After 2 weeks of ICV-STZ infusion, rats were tested for cognitive performance using passive avoidance and water maze tasks, and then killed for biochemical assays. ICV-STZ induced significant declines in cognitive performance and choline acetyltransferase activity in the hippocampus, which were significantly attenuated with PYC and Vit E. Pretreatment with PYC and Vit E produced a significantly enhanced glutathione level and Na+/K+-ATPase activity and decreased thiobarbituric acid reactive substances and protein carbonyl. These findings suggest that PYC and Vit E may provide a promising approach for the treatment of oxidative stress-related neurodegeneration in conditions such as AD.

Authors+Show Affiliations

Department of Medical Elementology and Toxicology, Neurotoxicology Laboratory, Jamia Hamdard (Hamdard University), New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19654508

Citation

Ishrat, Tauheed, et al. "Effects of Pycnogenol and Vitamin E On Cognitive Deficits and Oxidative Damage Induced By Intracerebroventricular Streptozotocin in Rats." Behavioural Pharmacology, vol. 20, no. 7, 2009, pp. 567-75.
Ishrat T, Parveen K, Hoda MN, et al. Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats. Behav Pharmacol. 2009;20(7):567-75.
Ishrat, T., Parveen, K., Hoda, M. N., Khan, M. B., Yousuf, S., Ansari, M. A., Saleem, S., & Islam, F. (2009). Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats. Behavioural Pharmacology, 20(7), 567-75. https://doi.org/10.1097/FBP.0b013e32832c7125
Ishrat T, et al. Effects of Pycnogenol and Vitamin E On Cognitive Deficits and Oxidative Damage Induced By Intracerebroventricular Streptozotocin in Rats. Behav Pharmacol. 2009;20(7):567-75. PubMed PMID: 19654508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats. AU - Ishrat,Tauheed, AU - Parveen,Kehkashan, AU - Hoda,Md Nasrul, AU - Khan,Mohammad Badruzzaman, AU - Yousuf,Seema, AU - Ansari,Mubeen Ahmad, AU - Saleem,Sofiyan, AU - Islam,Fakhrul, PY - 2009/8/6/entrez PY - 2009/8/6/pubmed PY - 2011/2/9/medline SP - 567 EP - 75 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 20 IS - 7 N2 - Oxidative stress plays a crucial role in the progression of cognitive decline in Alzheimer's disease (AD). Considerable attention has been focused on increasing the internal antioxidant defenses in response to AD. This study was designed to examine and compare the pretreatment effects of Pycnogenol (PYC) and vitamin E (Vit E) on cognitive deficits and oxidative damage in the hippocampus and cerebral cortex of intracerebroventricular streptozotocin (ICV-STZ)-infused rats. Rats pretreated with PYC (10 mg/kg), Vit E (100 mg/kg), and vehicle (intraperitoneal; once daily for 3 weeks) were bilaterally injected with ICV-STZ (3 mg/kg), whereas sham rats received the same volume of vehicle. After 2 weeks of ICV-STZ infusion, rats were tested for cognitive performance using passive avoidance and water maze tasks, and then killed for biochemical assays. ICV-STZ induced significant declines in cognitive performance and choline acetyltransferase activity in the hippocampus, which were significantly attenuated with PYC and Vit E. Pretreatment with PYC and Vit E produced a significantly enhanced glutathione level and Na+/K+-ATPase activity and decreased thiobarbituric acid reactive substances and protein carbonyl. These findings suggest that PYC and Vit E may provide a promising approach for the treatment of oxidative stress-related neurodegeneration in conditions such as AD. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/19654508/Effects_of_Pycnogenol_and_vitamin_E_on_cognitive_deficits_and_oxidative_damage_induced_by_intracerebroventricular_streptozotocin_in_rats_ L2 - https://doi.org/10.1097/FBP.0b013e32832c7125 DB - PRIME DP - Unbound Medicine ER -