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Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients.
Oral Dis. 2010 Jan; 16(1):29-33.OD

Abstract

BACKGROUND AND OBJECTIVE

Increased oxidative and nitrosative stress associated with disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases, most notably oral cancer. The aim of this study was to evaluate the oxidant-antioxidant status in blood samples and tumor tissue in oral squamous cell carcinoma (OSCC) patients in comparison with the healthy controls.

METHODS

Blood and tumor tissue samples from the diseased individuals and the normal controls were analyzed for malondialdehyde (MDA) and nitric oxide (NO) as indicators of oxidative stress and nitrosative stress respectively; superoxide dismutase (SOD) and catalase enzymes as indicators of antioxidant defense by UV visible spectrophotometer.

RESULTS

Malondialdehyde and NO levels were significantly elevated in the blood and tissue samples of OSCC patients as compared with the healthy controls. The antioxidant enzymes SOD and catalase were significantly reduced in tissue samples of OSCC group than in the control group while in the erythrocytes, catalase levels were significantly reduced and the SOD levels were higher in OSCC group in comparison with the healthy controls.

INTERPRETATION AND CONCLUSION

Increased levels of MDA and NO indicate an increase in the oxidative stress in OSCC patients associated with a deficient antioxidant defense mechanism. This oxidant-antioxidant imbalance may be considered as one of the factors responsible for pathogenesis of cancer. Future studies regarding assessment of oxidant-antioxidant status in OSCC patients in view of selecting appropriate mode of therapy and the effectiveness of such therapy in limiting the tumor progression and recurrence is to be carried out.

Authors+Show Affiliations

Department of Oral and Maxillofacial Pathology, S.D.M. College of Dental Sciences and Hospital, Sattur, Dharwad 580009, Karnataka, India. drgokuls@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19656315

Citation

Gokul, S, et al. "Oxidant-antioxidant Status in Blood and Tumor Tissue of Oral Squamous Cell Carcinoma Patients." Oral Diseases, vol. 16, no. 1, 2010, pp. 29-33.
Gokul S, Patil VS, Jailkhani R, et al. Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients. Oral Dis. 2010;16(1):29-33.
Gokul, S., Patil, V. S., Jailkhani, R., Hallikeri, K., & Kattappagari, K. K. (2010). Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients. Oral Diseases, 16(1), 29-33. https://doi.org/10.1111/j.1601-0825.2009.01598.x
Gokul S, et al. Oxidant-antioxidant Status in Blood and Tumor Tissue of Oral Squamous Cell Carcinoma Patients. Oral Dis. 2010;16(1):29-33. PubMed PMID: 19656315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients. AU - Gokul,S, AU - Patil,V S, AU - Jailkhani,R, AU - Hallikeri,K, AU - Kattappagari,K K, Y1 - 2009/07/08/ PY - 2009/8/7/entrez PY - 2009/8/7/pubmed PY - 2010/6/19/medline SP - 29 EP - 33 JF - Oral diseases JO - Oral Dis VL - 16 IS - 1 N2 - BACKGROUND AND OBJECTIVE: Increased oxidative and nitrosative stress associated with disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases, most notably oral cancer. The aim of this study was to evaluate the oxidant-antioxidant status in blood samples and tumor tissue in oral squamous cell carcinoma (OSCC) patients in comparison with the healthy controls. METHODS: Blood and tumor tissue samples from the diseased individuals and the normal controls were analyzed for malondialdehyde (MDA) and nitric oxide (NO) as indicators of oxidative stress and nitrosative stress respectively; superoxide dismutase (SOD) and catalase enzymes as indicators of antioxidant defense by UV visible spectrophotometer. RESULTS: Malondialdehyde and NO levels were significantly elevated in the blood and tissue samples of OSCC patients as compared with the healthy controls. The antioxidant enzymes SOD and catalase were significantly reduced in tissue samples of OSCC group than in the control group while in the erythrocytes, catalase levels were significantly reduced and the SOD levels were higher in OSCC group in comparison with the healthy controls. INTERPRETATION AND CONCLUSION: Increased levels of MDA and NO indicate an increase in the oxidative stress in OSCC patients associated with a deficient antioxidant defense mechanism. This oxidant-antioxidant imbalance may be considered as one of the factors responsible for pathogenesis of cancer. Future studies regarding assessment of oxidant-antioxidant status in OSCC patients in view of selecting appropriate mode of therapy and the effectiveness of such therapy in limiting the tumor progression and recurrence is to be carried out. SN - 1601-0825 UR - https://www.unboundmedicine.com/medline/citation/19656315/Oxidant_antioxidant_status_in_blood_and_tumor_tissue_of_oral_squamous_cell_carcinoma_patients_ L2 - https://doi.org/10.1111/j.1601-0825.2009.01598.x DB - PRIME DP - Unbound Medicine ER -