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Long-term outcome on renal replacement therapy in patients who previously received a keto acid-supplemented very-low-protein diet.
Am J Clin Nutr. 2009 Oct; 90(4):969-74.AJ

Abstract

BACKGROUND

The consequences of a supplemented very-low-protein diet remain a matter of debate with regard to patient outcome before or after the onset of renal replacement therapy.

OBJECTIVE

We evaluated the long-term clinical outcome during maintenance dialysis and/or transplantation in patients who previously received a supplemented very-low-protein diet.

DESIGN

We assessed the outcome of 203 patients who received a supplemented very-low-protein diet for >3 mo (inclusion period: 1985-2000) and started dialysis after a mean diet duration of 33.1 mo (4-230 mo).

RESULTS

The survival rate in the whole cohort was 79% and 63% at 5 and 10 y, respectively. One hundred two patients continued with chronic dialysis during the entire follow-up, and 101 patients were grafted at least once. Patient outcomes were similar to those of the French Dialysis Registry patients for the dialysis group and similar to the 865 patients who were transplanted in Bordeaux during the same period for the transplant group. There was no correlation between death rate and duration of diet.

CONCLUSIONS

The lack of correlation between death rate and duration of diet and the moderate mortality rate observed during the first 10 y of renal replacement therapy confirm that a supplemented very-low-protein diet has no detrimental effect on the outcome of patients with chronic kidney disease who receive renal replacement therapy.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chauveau P
Department of Nephrology, Centre Hospitalier Universitaire and University Bordeaux II, Bordeaux, France. ph.chauveau@wanadoo.fr
Couzi L
No affiliation info available
Vendrely B
No affiliation info available
de Précigout V
No affiliation info available
Combe C
No affiliation info available
Fouque D
No affiliation info available
Aparicio M
No affiliation info available

MeSH

AdultAgedDiet, Protein-RestrictedDietary SupplementsHumansKeto AcidsKidney Failure, ChronicKidney TransplantationMiddle AgedRenal DialysisSurvival RateTime FactorsTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19656840

Citation

Chauveau, Philippe, et al. "Long-term Outcome On Renal Replacement Therapy in Patients Who Previously Received a Keto Acid-supplemented Very-low-protein Diet." The American Journal of Clinical Nutrition, vol. 90, no. 4, 2009, pp. 969-74.
Chauveau P, Couzi L, Vendrely B, et al. Long-term outcome on renal replacement therapy in patients who previously received a keto acid-supplemented very-low-protein diet. Am J Clin Nutr. 2009;90(4):969-74.
Chauveau, P., Couzi, L., Vendrely, B., de Précigout, V., Combe, C., Fouque, D., & Aparicio, M. (2009). Long-term outcome on renal replacement therapy in patients who previously received a keto acid-supplemented very-low-protein diet. The American Journal of Clinical Nutrition, 90(4), 969-74. https://doi.org/10.3945/ajcn.2009.27980
Chauveau P, et al. Long-term Outcome On Renal Replacement Therapy in Patients Who Previously Received a Keto Acid-supplemented Very-low-protein Diet. Am J Clin Nutr. 2009;90(4):969-74. PubMed PMID: 19656840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term outcome on renal replacement therapy in patients who previously received a keto acid-supplemented very-low-protein diet. AU - Chauveau,Philippe, AU - Couzi,Lionel, AU - Vendrely,Benoit, AU - de Précigout,Valérie, AU - Combe,Christian, AU - Fouque,Denis, AU - Aparicio,Michel, Y1 - 2009/08/05/ PY - 2009/8/7/entrez PY - 2009/8/7/pubmed PY - 2009/10/10/medline SP - 969 EP - 74 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 90 IS - 4 N2 - BACKGROUND: The consequences of a supplemented very-low-protein diet remain a matter of debate with regard to patient outcome before or after the onset of renal replacement therapy. OBJECTIVE: We evaluated the long-term clinical outcome during maintenance dialysis and/or transplantation in patients who previously received a supplemented very-low-protein diet. DESIGN: We assessed the outcome of 203 patients who received a supplemented very-low-protein diet for >3 mo (inclusion period: 1985-2000) and started dialysis after a mean diet duration of 33.1 mo (4-230 mo). RESULTS: The survival rate in the whole cohort was 79% and 63% at 5 and 10 y, respectively. One hundred two patients continued with chronic dialysis during the entire follow-up, and 101 patients were grafted at least once. Patient outcomes were similar to those of the French Dialysis Registry patients for the dialysis group and similar to the 865 patients who were transplanted in Bordeaux during the same period for the transplant group. There was no correlation between death rate and duration of diet. CONCLUSIONS: The lack of correlation between death rate and duration of diet and the moderate mortality rate observed during the first 10 y of renal replacement therapy confirm that a supplemented very-low-protein diet has no detrimental effect on the outcome of patients with chronic kidney disease who receive renal replacement therapy. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19656840/Long_term_outcome_on_renal_replacement_therapy_in_patients_who_previously_received_a_keto_acid_supplemented_very_low_protein_diet_ DB - PRIME DP - Unbound Medicine ER -