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Is active sweating during heat acclimation required for improvements in peripheral sweat gland function?
Am J Physiol Regul Integr Comp Physiol. 2009 Oct; 297(4):R1082-5.AJ

Abstract

We investigated whether the eccrine sweat glands must actively produce sweat during heat acclimation if they are to adapt and increase their capacity to sweat. Eight volunteers received intradermal injections of BOTOX, to prevent neural stimulation and sweat production of the sweat glands during heat acclimation, and saline injections as a control in the contralateral forearm. Subjects performed 90 min of moderate-intensity exercise in the heat (35 degrees C, 40% relative humidity) on 10 consecutive days. Heat acclimation decreased end-exercise heart rate (156 +/- 22 vs. 138 +/- 17 beats/min; P = 0.0001) and rectal temperature (38.2 +/- 0.3 vs. 37.9 +/- 0.3 degrees C; P = 0.0003) and increased whole body sweat rate (0.70 +/- 0.29 vs. 1.06 +/- 0.50 l/h; P = 0.030). During heat acclimation, there was no measurable sweating in the BOTOX-treated forearm, but the control forearm sweat rate during exercise increased 40% over the 10 days (P = 0.040). Peripheral sweat gland function was assessed using pilocarpine iontophoresis before and after heat acclimation. Before heat acclimation, the pilocarpine-induced sweat rate of the control and BOTOX-injected forearms did not differ (0.65 +/- 0.20 vs. 0.66 +/- 0.22 mg x cm(-2) x min(-1)). However, following heat acclimation, the pilocarpine-induced sweat rate in the control arm increased 18% to 0.77 +/- 0.21 mg x cm(-2) x min(-1) (P = 0.021) but decreased 52% to 0.32 +/- 0.18 mg x cm(-2) x min(-1) (P < 0.001) in the BOTOX-treated arm. Using complete chemodenervation of the sweat glands, coupled with direct cholinergic stimulation via pilocarpine iontophoresis, we demonstrated that sweat glands must be active during heat acclimation if they are to adapt and increase their capacity to sweat.

Authors+Show Affiliations

Department of Biology, School of Exercise and Nutritional Sciences, San Diego State University, San Diego, California, USA. mbuono@mail.sdsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19657101

Citation

Buono, Michael J., et al. "Is Active Sweating During Heat Acclimation Required for Improvements in Peripheral Sweat Gland Function?" American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 297, no. 4, 2009, pp. R1082-5.
Buono MJ, Numan TR, Claros RM, et al. Is active sweating during heat acclimation required for improvements in peripheral sweat gland function? Am J Physiol Regul Integr Comp Physiol. 2009;297(4):R1082-5.
Buono, M. J., Numan, T. R., Claros, R. M., Brodine, S. K., & Kolkhorst, F. W. (2009). Is active sweating during heat acclimation required for improvements in peripheral sweat gland function? American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 297(4), R1082-5. https://doi.org/10.1152/ajpregu.00253.2009
Buono MJ, et al. Is Active Sweating During Heat Acclimation Required for Improvements in Peripheral Sweat Gland Function. Am J Physiol Regul Integr Comp Physiol. 2009;297(4):R1082-5. PubMed PMID: 19657101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is active sweating during heat acclimation required for improvements in peripheral sweat gland function? AU - Buono,Michael J, AU - Numan,Travis R, AU - Claros,Ryan M, AU - Brodine,Stephanie K, AU - Kolkhorst,Fred W, Y1 - 2009/08/05/ PY - 2009/8/7/entrez PY - 2009/8/7/pubmed PY - 2009/10/14/medline SP - R1082 EP - 5 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am J Physiol Regul Integr Comp Physiol VL - 297 IS - 4 N2 - We investigated whether the eccrine sweat glands must actively produce sweat during heat acclimation if they are to adapt and increase their capacity to sweat. Eight volunteers received intradermal injections of BOTOX, to prevent neural stimulation and sweat production of the sweat glands during heat acclimation, and saline injections as a control in the contralateral forearm. Subjects performed 90 min of moderate-intensity exercise in the heat (35 degrees C, 40% relative humidity) on 10 consecutive days. Heat acclimation decreased end-exercise heart rate (156 +/- 22 vs. 138 +/- 17 beats/min; P = 0.0001) and rectal temperature (38.2 +/- 0.3 vs. 37.9 +/- 0.3 degrees C; P = 0.0003) and increased whole body sweat rate (0.70 +/- 0.29 vs. 1.06 +/- 0.50 l/h; P = 0.030). During heat acclimation, there was no measurable sweating in the BOTOX-treated forearm, but the control forearm sweat rate during exercise increased 40% over the 10 days (P = 0.040). Peripheral sweat gland function was assessed using pilocarpine iontophoresis before and after heat acclimation. Before heat acclimation, the pilocarpine-induced sweat rate of the control and BOTOX-injected forearms did not differ (0.65 +/- 0.20 vs. 0.66 +/- 0.22 mg x cm(-2) x min(-1)). However, following heat acclimation, the pilocarpine-induced sweat rate in the control arm increased 18% to 0.77 +/- 0.21 mg x cm(-2) x min(-1) (P = 0.021) but decreased 52% to 0.32 +/- 0.18 mg x cm(-2) x min(-1) (P < 0.001) in the BOTOX-treated arm. Using complete chemodenervation of the sweat glands, coupled with direct cholinergic stimulation via pilocarpine iontophoresis, we demonstrated that sweat glands must be active during heat acclimation if they are to adapt and increase their capacity to sweat. SN - 1522-1490 UR - https://www.unboundmedicine.com/medline/citation/19657101/Is_active_sweating_during_heat_acclimation_required_for_improvements_in_peripheral_sweat_gland_function L2 - https://journals.physiology.org/doi/10.1152/ajpregu.00253.2009?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -