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Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery.
Med Sci Sports Exerc. 2009 Sep; 41(9):1752-60.MS

Abstract

PURPOSE

This study aimed to determine the effects of 4 wk of antioxidants (AOX) supplementation on exercise-induced lipid peroxidation, muscle damage, and inflammation in kayakers.

METHODS

Subjects (n = 20) were randomly assigned to receive a placebo (PLA) or an AOX capsule (AOX; 272 mg of alpha-tocopherol, 400 mg of vitamin C, 30 mg of beta-carotene, 2 mg of lutein, 400 mug of selenium, 30 mg of zinc, and 600 mg of magnesium). Blood samples were collected at rest and 15 min after a 1000-m kayak race, both before and after the supplementation period, for analysis of alpha-tocopherol, alpha-carotene, beta-carotene, lycopene, lutein plus zeaxanthin, vitamin C, uric acid, total AOX status (TAS), thiobarbituric reactive acid substances (TBARS) and interleukin-6 (IL-6) levels, and creatine kinase (CK), superoxide dismutase (SOD), glutathione reductase (Gr), and glutathione peroxidase (GPx) activities.

RESULTS

With supplementation, plasma alpha-tocopherol (P = 0.003) and beta-carotene (P = 0.007) augmented significantly in the AOX group. IL-6 (exercise, P = 0.039), TBARS (exercise, P < 0.001), and uric acid (exercise, P = 0.032) increased significantly in response to the exercise regardless of treatment group. Cortisol level raised more from pre- to postsupplementation period in the PLA group (time x supplementation, P = 0.002). Although TAS declined after exercise before intervention, it increased above preexercise values after the 4-wk period in the AOX group (supplementation x time x exercise, P = 0.034). CK increased after exercise in both groups (exercise effect, P < 0.001) and decreased from week 0 to week 4 more markedly in the PLA group (supplementation x time, P = 0.049).

CONCLUSIONS

AOX supplementation does not offer protection against exercise-induced lipid peroxidation and inflammation and may hinder the recovery of muscle damage.

Authors+Show Affiliations

Faculty of Nutrition and Food Sciences, University of Porto, Porto, Potugal. vhugoteixeira@fcna.up.ptNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19657294

Citation

Teixeira, Vitor H., et al. "Antioxidants Do Not Prevent Postexercise Peroxidation and May Delay Muscle Recovery." Medicine and Science in Sports and Exercise, vol. 41, no. 9, 2009, pp. 1752-60.
Teixeira VH, Valente HF, Casal SI, et al. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Med Sci Sports Exerc. 2009;41(9):1752-60.
Teixeira, V. H., Valente, H. F., Casal, S. I., Marques, A. F., & Moreira, P. A. (2009). Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Medicine and Science in Sports and Exercise, 41(9), 1752-60. https://doi.org/10.1249/MSS.0b013e31819fe8e3
Teixeira VH, et al. Antioxidants Do Not Prevent Postexercise Peroxidation and May Delay Muscle Recovery. Med Sci Sports Exerc. 2009;41(9):1752-60. PubMed PMID: 19657294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. AU - Teixeira,Vitor H, AU - Valente,Hugo F, AU - Casal,Susana I, AU - Marques,A Franklim, AU - Moreira,Pedro A, PY - 2009/8/7/entrez PY - 2009/8/7/pubmed PY - 2009/12/23/medline SP - 1752 EP - 60 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 41 IS - 9 N2 - PURPOSE: This study aimed to determine the effects of 4 wk of antioxidants (AOX) supplementation on exercise-induced lipid peroxidation, muscle damage, and inflammation in kayakers. METHODS: Subjects (n = 20) were randomly assigned to receive a placebo (PLA) or an AOX capsule (AOX; 272 mg of alpha-tocopherol, 400 mg of vitamin C, 30 mg of beta-carotene, 2 mg of lutein, 400 mug of selenium, 30 mg of zinc, and 600 mg of magnesium). Blood samples were collected at rest and 15 min after a 1000-m kayak race, both before and after the supplementation period, for analysis of alpha-tocopherol, alpha-carotene, beta-carotene, lycopene, lutein plus zeaxanthin, vitamin C, uric acid, total AOX status (TAS), thiobarbituric reactive acid substances (TBARS) and interleukin-6 (IL-6) levels, and creatine kinase (CK), superoxide dismutase (SOD), glutathione reductase (Gr), and glutathione peroxidase (GPx) activities. RESULTS: With supplementation, plasma alpha-tocopherol (P = 0.003) and beta-carotene (P = 0.007) augmented significantly in the AOX group. IL-6 (exercise, P = 0.039), TBARS (exercise, P < 0.001), and uric acid (exercise, P = 0.032) increased significantly in response to the exercise regardless of treatment group. Cortisol level raised more from pre- to postsupplementation period in the PLA group (time x supplementation, P = 0.002). Although TAS declined after exercise before intervention, it increased above preexercise values after the 4-wk period in the AOX group (supplementation x time x exercise, P = 0.034). CK increased after exercise in both groups (exercise effect, P < 0.001) and decreased from week 0 to week 4 more markedly in the PLA group (supplementation x time, P = 0.049). CONCLUSIONS: AOX supplementation does not offer protection against exercise-induced lipid peroxidation and inflammation and may hinder the recovery of muscle damage. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/19657294/Antioxidants_do_not_prevent_postexercise_peroxidation_and_may_delay_muscle_recovery_ L2 - https://doi.org/10.1249/MSS.0b013e31819fe8e3 DB - PRIME DP - Unbound Medicine ER -