Tags

Type your tag names separated by a space and hit enter

No significant association between Fc receptor-like 3 gene polymorphisms and human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese population.
Mol Biol Rep. 2010 Jan; 37(1):297-300.MB

Abstract

Ankylosing spondylitis (AS) is a rheumatoid arthritis, which is a common autoimmune disease with a complex genetic etiology. Although HLA-B27 has been identified to be associated with AS, a number of other genes may also be involved in the disease. Fc receptor-like 3 (FCRL3) gene has been shown to be associated with rheumatoid arthritis in Japanese population. Here we aim to explore the association FCRL3 gene and susceptibility to human leukocyte antigen (HLA)-B27-positive AS in Han Chinese population. Among 169 AS patients, the frequencies of C and T (rs7522061) in FCRL3 gene were 38.7 and 61.3%, respectively; in 184 controls (HLA-B27-positive), the frequencies of C and T were 38.6 and 61.4%, respectively. The frequencies of alleles and genotype are not of statistically significant difference in two groups (chi(2) = 0.000, P = 0.983; chi(2) = 0.099, P = 0.952, respectively), but the distribution of HLA-B27 subtypes are statistically significant difference between cases and controls (chi(2) = 8.214, P = 0.042). Our data reveal that the FCRL3 gene does not appear associated with susceptibility to HLA-B27-positive AS in Han Chinese population.

Links

Aggregator Full Text

Authors+Show Affiliations

Xia G
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, China.
Pan F
No affiliation info available
Liao F
No affiliation info available
Tang X
No affiliation info available
Ge R
No affiliation info available
Mei Y
No affiliation info available
Pan H
No affiliation info available
Xu S
No affiliation info available
Xu J
No affiliation info available

MeSH

AdultAsian Continental Ancestry GroupCase-Control StudiesChinaEthnic GroupsFemaleGene FrequencyGenetic Predisposition to DiseaseHLA-B27 AntigenHumansMalePolymorphism, Single NucleotideReceptors, ImmunologicSpondylitis, Ankylosing

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19657722

Citation

Xia, Guo, et al. "No Significant Association Between Fc Receptor-like 3 Gene Polymorphisms and Human Leukocyte antigen-B27 Positive Ankylosing Spondylitis in Han Chinese Population." Molecular Biology Reports, vol. 37, no. 1, 2010, pp. 297-300.
Xia G, Pan F, Liao F, et al. No significant association between Fc receptor-like 3 gene polymorphisms and human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese population. Mol Biol Rep. 2010;37(1):297-300.
Xia, G., Pan, F., Liao, F., Tang, X., Ge, R., Mei, Y., Pan, H., Xu, S., & Xu, J. (2010). No significant association between Fc receptor-like 3 gene polymorphisms and human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese population. Molecular Biology Reports, 37(1), 297-300. https://doi.org/10.1007/s11033-009-9690-4
Xia G, et al. No Significant Association Between Fc Receptor-like 3 Gene Polymorphisms and Human Leukocyte antigen-B27 Positive Ankylosing Spondylitis in Han Chinese Population. Mol Biol Rep. 2010;37(1):297-300. PubMed PMID: 19657722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No significant association between Fc receptor-like 3 gene polymorphisms and human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese population. AU - Xia,Guo, AU - Pan,Faming, AU - Liao,Fangfang, AU - Tang,Xiaowu, AU - Ge,Rui, AU - Mei,Yang, AU - Pan,Heping, AU - Xu,Shengqian, AU - Xu,Jianhua, Y1 - 2009/08/06/ PY - 2009/02/09/received PY - 2009/07/28/accepted PY - 2009/8/7/entrez PY - 2009/8/7/pubmed PY - 2010/3/11/medline SP - 297 EP - 300 JF - Molecular biology reports JO - Mol Biol Rep VL - 37 IS - 1 N2 - Ankylosing spondylitis (AS) is a rheumatoid arthritis, which is a common autoimmune disease with a complex genetic etiology. Although HLA-B27 has been identified to be associated with AS, a number of other genes may also be involved in the disease. Fc receptor-like 3 (FCRL3) gene has been shown to be associated with rheumatoid arthritis in Japanese population. Here we aim to explore the association FCRL3 gene and susceptibility to human leukocyte antigen (HLA)-B27-positive AS in Han Chinese population. Among 169 AS patients, the frequencies of C and T (rs7522061) in FCRL3 gene were 38.7 and 61.3%, respectively; in 184 controls (HLA-B27-positive), the frequencies of C and T were 38.6 and 61.4%, respectively. The frequencies of alleles and genotype are not of statistically significant difference in two groups (chi(2) = 0.000, P = 0.983; chi(2) = 0.099, P = 0.952, respectively), but the distribution of HLA-B27 subtypes are statistically significant difference between cases and controls (chi(2) = 8.214, P = 0.042). Our data reveal that the FCRL3 gene does not appear associated with susceptibility to HLA-B27-positive AS in Han Chinese population. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/19657722/No_significant_association_between_Fc_receptor_like_3_gene_polymorphisms_and_human_leukocyte_antigen_B27_positive_ankylosing_spondylitis_in_Han_Chinese_population_ L2 - https://doi.org/10.1007/s11033-009-9690-4 DB - PRIME DP - Unbound Medicine ER -