Tags

Type your tag names separated by a space and hit enter

Aortic valve leaflet mechanical properties facilitate diastolic valve function.

Abstract

This work was concerned with the numerical simulation of the behaviour of aortic valves whose material can be modelled as non-linear elastic anisotropic. Linear elastic models for the valve leaflets with parameters used in previous studies were compared with hyperelastic models, incorporating leaflet anisotropy with pronounced stiffness in the circumferential direction through a transverse isotropic model. The parameters for the hyperelastic models were obtained from fits to results of orthogonal uniaxial tensile tests on porcine aortic valve leaflets. The computational results indicated the significant impact of transverse isotropy and hyperelastic effects on leaflet mechanics; in particular, increased coaptation with peak values of stress and strain in the elastic limit. The alignment of maximum principal stresses in all models follows approximately the coarse collagen fibre distribution found in aortic valve leaflets. The non-linear elastic leaflets also demonstrated more evenly distributed stress and strain which appears relevant to long-term scaffold stability and mechanotransduction.

Authors+Show Affiliations

Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19657802

Citation

Koch, T M., et al. "Aortic Valve Leaflet Mechanical Properties Facilitate Diastolic Valve Function." Computer Methods in Biomechanics and Biomedical Engineering, vol. 13, no. 2, 2010, pp. 225-34.
Koch TM, Reddy BD, Zilla P, et al. Aortic valve leaflet mechanical properties facilitate diastolic valve function. Comput Methods Biomech Biomed Engin. 2010;13(2):225-34.
Koch, T. M., Reddy, B. D., Zilla, P., & Franz, T. (2010). Aortic valve leaflet mechanical properties facilitate diastolic valve function. Computer Methods in Biomechanics and Biomedical Engineering, 13(2), 225-34. https://doi.org/10.1080/10255840903120160
Koch TM, et al. Aortic Valve Leaflet Mechanical Properties Facilitate Diastolic Valve Function. Comput Methods Biomech Biomed Engin. 2010;13(2):225-34. PubMed PMID: 19657802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aortic valve leaflet mechanical properties facilitate diastolic valve function. AU - Koch,T M, AU - Reddy,B D, AU - Zilla,P, AU - Franz,T, PY - 2009/8/7/entrez PY - 2009/8/7/pubmed PY - 2011/7/6/medline SP - 225 EP - 34 JF - Computer methods in biomechanics and biomedical engineering JO - Comput Methods Biomech Biomed Engin VL - 13 IS - 2 N2 - This work was concerned with the numerical simulation of the behaviour of aortic valves whose material can be modelled as non-linear elastic anisotropic. Linear elastic models for the valve leaflets with parameters used in previous studies were compared with hyperelastic models, incorporating leaflet anisotropy with pronounced stiffness in the circumferential direction through a transverse isotropic model. The parameters for the hyperelastic models were obtained from fits to results of orthogonal uniaxial tensile tests on porcine aortic valve leaflets. The computational results indicated the significant impact of transverse isotropy and hyperelastic effects on leaflet mechanics; in particular, increased coaptation with peak values of stress and strain in the elastic limit. The alignment of maximum principal stresses in all models follows approximately the coarse collagen fibre distribution found in aortic valve leaflets. The non-linear elastic leaflets also demonstrated more evenly distributed stress and strain which appears relevant to long-term scaffold stability and mechanotransduction. SN - 1476-8259 UR - https://www.unboundmedicine.com/medline/citation/19657802/Aortic_valve_leaflet_mechanical_properties_facilitate_diastolic_valve_function_ L2 - http://www.tandfonline.com/doi/full/10.1080/10255840903120160 DB - PRIME DP - Unbound Medicine ER -