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Allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis.
Eur J Cancer Care (Engl) 2010; 19(3):308-12EJ

Abstract

To prepare and evaluate an allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis, 33 patients with malignant disorders, who were going to receive 5-fluorouracil containing chemotherapy, were enrolled in a placebo-controlled double-blinded randomized clinical trial. Allopurinol mouthwash (1 mg/ml) or placebo was administered 1, 2 and 3 h after chemotherapy and three consecutive nights. A questionnaire consisting of demographic parameters, medical status, quality of life survey and mucosal injury scoring table (based on World Health Organization scales for mucositis) was completed for each patient at Day 1, 3 and 7 after chemotherapy. In allopurinol group nine participants (60.0%) were female and in placebo group, 10 (66.7%) (P = 0.705). Mean ages were 56.9 +/- 10.3 and 49.5 +/- 13.8 years in allopurinol and placebo groups respectively (P = 0.107). The analysis showed that the higher education level and the use of dentures significantly reduced the occurrence of mucositis, and allopurinol mouth rinse (1 mg/ml) was ineffective in the prophylaxis of fluorouracil-induced mucositis.

Authors+Show Affiliations

Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran. yunespanahi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19659665

Citation

Panahi, Y, et al. "Allopurinol Mouth Rinse for Prophylaxis of Fluorouracil-induced Mucositis." European Journal of Cancer Care, vol. 19, no. 3, 2010, pp. 308-12.
Panahi Y, Ala S, Saeedi M, et al. Allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis. Eur J Cancer Care (Engl). 2010;19(3):308-12.
Panahi, Y., Ala, S., Saeedi, M., Okhovatian, A., Bazzaz, N., & Naghizadeh, M. M. (2010). Allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis. European Journal of Cancer Care, 19(3), pp. 308-12. doi:10.1111/j.1365-2354.2008.01042.x.
Panahi Y, et al. Allopurinol Mouth Rinse for Prophylaxis of Fluorouracil-induced Mucositis. Eur J Cancer Care (Engl). 2010;19(3):308-12. PubMed PMID: 19659665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis. AU - Panahi,Y, AU - Ala,S, AU - Saeedi,M, AU - Okhovatian,A, AU - Bazzaz,N, AU - Naghizadeh,M M, Y1 - 2009/07/29/ PY - 2009/8/8/entrez PY - 2009/8/8/pubmed PY - 2010/10/30/medline SP - 308 EP - 12 JF - European journal of cancer care JO - Eur J Cancer Care (Engl) VL - 19 IS - 3 N2 - To prepare and evaluate an allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis, 33 patients with malignant disorders, who were going to receive 5-fluorouracil containing chemotherapy, were enrolled in a placebo-controlled double-blinded randomized clinical trial. Allopurinol mouthwash (1 mg/ml) or placebo was administered 1, 2 and 3 h after chemotherapy and three consecutive nights. A questionnaire consisting of demographic parameters, medical status, quality of life survey and mucosal injury scoring table (based on World Health Organization scales for mucositis) was completed for each patient at Day 1, 3 and 7 after chemotherapy. In allopurinol group nine participants (60.0%) were female and in placebo group, 10 (66.7%) (P = 0.705). Mean ages were 56.9 +/- 10.3 and 49.5 +/- 13.8 years in allopurinol and placebo groups respectively (P = 0.107). The analysis showed that the higher education level and the use of dentures significantly reduced the occurrence of mucositis, and allopurinol mouth rinse (1 mg/ml) was ineffective in the prophylaxis of fluorouracil-induced mucositis. SN - 1365-2354 UR - https://www.unboundmedicine.com/medline/citation/19659665/Allopurinol_mouth_rinse_for_prophylaxis_of_fluorouracil_induced_mucositis_ L2 - https://doi.org/10.1111/j.1365-2354.2008.01042.x DB - PRIME DP - Unbound Medicine ER -