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Vitamin D and cognitive performance in adults: a systematic review.

Abstract

Chronic low serum 25-hydroxyvitamin D (25OHD) concentrations are common in adults and are associated with numerous non-skeletal diseases. Vitamin D receptors (VDR) are located in the human cortex and hippocampus, which are key areas for cognition. The objective of this study was to systematically review all published data from the past 30 years which examined the association between serum 25OHD concentrations and cognitive performance in adults. An English and French Medline, PsycINFO and Cochrane Library search ranging from 1979 to 2008 indexed under the Medical Subject Heading (MeSH) terms 'Vitamin D' or 'Hydroxycholecalciferols' combined with the terms 'Dementia' or 'Cognition' or 'Cognition Disorders' or 'Delirium' or 'Memory' or 'Memory Disorders' or 'Orientation' or 'Executive Functions' or 'Attention' or 'Brain' or 'Neuropsychological Tests' was performed. Of the 99 selected studies, five observational studies met the selection criteria and were included in the final analysis. No prospective cohort study was found. The number of participants ranged from 32 to 9556 community-dwelling older adults (45-65% women). Three studies showed four significant positive associations between serum 25OHD concentrations and global cognitive functions, whereas three other studies exploring specific aspects of cognition showed 11 non-significant associations. This systematic review shows that the association between serum 25OHD concentrations and cognitive performance is not yet clearly established. The inconclusive results of the reviewed studies could be due to methodology, types of the cognitive tasks used and/or the cellular mechanisms of vitamin D.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine and Geriatrics, Angers University Hospital, Angers, France. ceannweiler@chu-angers.fr

    , , , , ,

    Source

    European journal of neurology 16:10 2009 Oct pg 1083-9

    MeSH

    Adult
    Aging
    Cognition
    Humans
    Receptors, Calcitriol
    Vitamin D

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    19659751

    Citation

    Annweiler, C, et al. "Vitamin D and Cognitive Performance in Adults: a Systematic Review." European Journal of Neurology, vol. 16, no. 10, 2009, pp. 1083-9.
    Annweiler C, Allali G, Allain P, et al. Vitamin D and cognitive performance in adults: a systematic review. Eur J Neurol. 2009;16(10):1083-9.
    Annweiler, C., Allali, G., Allain, P., Bridenbaugh, S., Schott, A. M., Kressig, R. W., & Beauchet, O. (2009). Vitamin D and cognitive performance in adults: a systematic review. European Journal of Neurology, 16(10), pp. 1083-9. doi:10.1111/j.1468-1331.2009.02755.x.
    Annweiler C, et al. Vitamin D and Cognitive Performance in Adults: a Systematic Review. Eur J Neurol. 2009;16(10):1083-9. PubMed PMID: 19659751.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D and cognitive performance in adults: a systematic review. AU - Annweiler,C, AU - Allali,G, AU - Allain,P, AU - Bridenbaugh,S, AU - Schott,A-M, AU - Kressig,R W, AU - Beauchet,O, Y1 - 2009/07/29/ PY - 2009/8/8/entrez PY - 2009/8/8/pubmed PY - 2009/12/16/medline SP - 1083 EP - 9 JF - European journal of neurology JO - Eur. J. Neurol. VL - 16 IS - 10 N2 - Chronic low serum 25-hydroxyvitamin D (25OHD) concentrations are common in adults and are associated with numerous non-skeletal diseases. Vitamin D receptors (VDR) are located in the human cortex and hippocampus, which are key areas for cognition. The objective of this study was to systematically review all published data from the past 30 years which examined the association between serum 25OHD concentrations and cognitive performance in adults. An English and French Medline, PsycINFO and Cochrane Library search ranging from 1979 to 2008 indexed under the Medical Subject Heading (MeSH) terms 'Vitamin D' or 'Hydroxycholecalciferols' combined with the terms 'Dementia' or 'Cognition' or 'Cognition Disorders' or 'Delirium' or 'Memory' or 'Memory Disorders' or 'Orientation' or 'Executive Functions' or 'Attention' or 'Brain' or 'Neuropsychological Tests' was performed. Of the 99 selected studies, five observational studies met the selection criteria and were included in the final analysis. No prospective cohort study was found. The number of participants ranged from 32 to 9556 community-dwelling older adults (45-65% women). Three studies showed four significant positive associations between serum 25OHD concentrations and global cognitive functions, whereas three other studies exploring specific aspects of cognition showed 11 non-significant associations. This systematic review shows that the association between serum 25OHD concentrations and cognitive performance is not yet clearly established. The inconclusive results of the reviewed studies could be due to methodology, types of the cognitive tasks used and/or the cellular mechanisms of vitamin D. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/19659751/Vitamin_D_and_cognitive_performance_in_adults:_a_systematic_review_ L2 - https://doi.org/10.1111/j.1468-1331.2009.02755.x DB - PRIME DP - Unbound Medicine ER -