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Assessment of perihematomal hypoperfusion injury in subacute and chronic intracerebral hemorrhage by CT perfusion imaging.
Neurol Res. 2010 Jul; 32(6):642-9.NR

Abstract

OBJECTIVE

To study alterations of perihematomal cerebral perfusion associated to subacute and chronic intracerebral hemorrhage (ICH) by means of computed tomography perfusion (CTP) imaging.

METHODS

Non-enhanced CT scan and CTP examination were performed in 12 patients with subacute and chronic supratentorial ICH. The hematoma volume was measured, and the regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), mean transit time (MTT) and time-to-peak (TTP) adjacent to hematoma were measured in 11 of 12 cases.

RESULTS

Eleven patients with mean age of 58.1 years were finally analysed. Mean time interval from symptom onset to initial CTP scanning was 18.4 days; mean hematoma volume was 26.8 ml. The gradient of hypoperfusion around the hematoma was revealed by rCBF maps in 11 cases, and by rCBV maps in ten cases. The areas of delayed TTP and MTT were showed in 11 and ten cases, respectively. The degree of reduction in rCBV correlated strongly with the hematoma volume (r(inner)=0.764, p=0.006;r(outer)=0.703, p=0.016). There was no correlation between the changes in rCBF, rCBV, MTT and TTP and the time interval from symptom onset to initial CTP examination.

CONCLUSION

We have concluded that the gradient of hypoperfusion surrounding the hematoma may still exist during the subacute and chronic phases after ICH. The alterations in rCBV correlate with the hematoma volume. We believe that the reperfusion injury marked by increased rCBV contributes to the perilesional brain injury. The quantitative CT perfusion measurements can provide valuable information in individual management and prognostic evaluation of ICH.

Authors+Show Affiliations

Neuroimaging Center, Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19660194

Citation

Zhou, Jian, et al. "Assessment of Perihematomal Hypoperfusion Injury in Subacute and Chronic Intracerebral Hemorrhage By CT Perfusion Imaging." Neurological Research, vol. 32, no. 6, 2010, pp. 642-9.
Zhou J, Zhang H, Gao P, et al. Assessment of perihematomal hypoperfusion injury in subacute and chronic intracerebral hemorrhage by CT perfusion imaging. Neurol Res. 2010;32(6):642-9.
Zhou, J., Zhang, H., Gao, P., Lin, Y., & Li, X. (2010). Assessment of perihematomal hypoperfusion injury in subacute and chronic intracerebral hemorrhage by CT perfusion imaging. Neurological Research, 32(6), 642-9. https://doi.org/10.1179/016164109X12445616596328
Zhou J, et al. Assessment of Perihematomal Hypoperfusion Injury in Subacute and Chronic Intracerebral Hemorrhage By CT Perfusion Imaging. Neurol Res. 2010;32(6):642-9. PubMed PMID: 19660194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of perihematomal hypoperfusion injury in subacute and chronic intracerebral hemorrhage by CT perfusion imaging. AU - Zhou,Jian, AU - Zhang,Hongmei, AU - Gao,Peiyi, AU - Lin,Yan, AU - Li,Xiaoguang, Y1 - 2009/08/05/ PY - 2009/8/8/entrez PY - 2009/8/8/pubmed PY - 2010/9/30/medline SP - 642 EP - 9 JF - Neurological research JO - Neurol. Res. VL - 32 IS - 6 N2 - OBJECTIVE: To study alterations of perihematomal cerebral perfusion associated to subacute and chronic intracerebral hemorrhage (ICH) by means of computed tomography perfusion (CTP) imaging. METHODS: Non-enhanced CT scan and CTP examination were performed in 12 patients with subacute and chronic supratentorial ICH. The hematoma volume was measured, and the regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), mean transit time (MTT) and time-to-peak (TTP) adjacent to hematoma were measured in 11 of 12 cases. RESULTS: Eleven patients with mean age of 58.1 years were finally analysed. Mean time interval from symptom onset to initial CTP scanning was 18.4 days; mean hematoma volume was 26.8 ml. The gradient of hypoperfusion around the hematoma was revealed by rCBF maps in 11 cases, and by rCBV maps in ten cases. The areas of delayed TTP and MTT were showed in 11 and ten cases, respectively. The degree of reduction in rCBV correlated strongly with the hematoma volume (r(inner)=0.764, p=0.006;r(outer)=0.703, p=0.016). There was no correlation between the changes in rCBF, rCBV, MTT and TTP and the time interval from symptom onset to initial CTP examination. CONCLUSION: We have concluded that the gradient of hypoperfusion surrounding the hematoma may still exist during the subacute and chronic phases after ICH. The alterations in rCBV correlate with the hematoma volume. We believe that the reperfusion injury marked by increased rCBV contributes to the perilesional brain injury. The quantitative CT perfusion measurements can provide valuable information in individual management and prognostic evaluation of ICH. SN - 1743-1328 UR - https://www.unboundmedicine.com/medline/citation/19660194/Assessment_of_perihematomal_hypoperfusion_injury_in_subacute_and_chronic_intracerebral_hemorrhage_by_CT_perfusion_imaging_ L2 - http://www.tandfonline.com/doi/full/10.1179/016164109X12445616596328 DB - PRIME DP - Unbound Medicine ER -