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Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers.
Nutrition. 2010 Feb; 26(2):175-83.N

Abstract

OBJECTIVE

Chlorella vulgaris is a popular food supplement in Asia and is currently marketed as a nutritional supplement. However, available scientific studies do not support its effectiveness for preventing or treating any disease in humans. Because Chlorella contains numerous nutrients, including antioxidants, it is thought to exert antioxidative functions by scavenging free radicals created by various environmental factors such as smoking. The purpose of this study was to investigate whether 6 wk of Chlorella supplementation to smokers is protective against oxidative damage in a randomized, double-blinded, placebo-controlled trial.

METHODS

Fifty-two smokers, aged 20-65 y, were given 6.3g of Chlorella or placebo every day for 6 wk. Blood samples were drawn at the beginning and after the supplementation. Plasma antioxidant vitamin levels and lipid peroxidation levels were measured. As a marker of oxidative stress, lymphocyte DNA damage was measured.

RESULTS

Chlorella supplementation increased plasma vitamin C (44.4%), alpha-tocopherol (15.7%), and erythrocyte catalase and superoxide dismutase activities. Although 6 wk of Chlorella supplementation resulted in a significant decrease in lymphocyte DNA damage, as measured by comet assay, placebo supplementation also decreased the measured amount of lymphocyte DNA damage.

CONCLUSION

Chlorella supplementation resulted in the conservation of plasma antioxidant nutrient status and improvement in erythrocyte antioxidant enzyme activities in subjects. Therefore, our results are supportive of an antioxidant role for Chlorella and indicate that Chlorella is an important whole-food supplement that should be included as a key component of a healthy diet.

Authors+Show Affiliations

Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19660910

Citation

Lee, Sun Hee, et al. "Six-week Supplementation With Chlorella Has Favorable Impact On Antioxidant Status in Korean Male Smokers." Nutrition (Burbank, Los Angeles County, Calif.), vol. 26, no. 2, 2010, pp. 175-83.
Lee SH, Kang HJ, Lee HJ, et al. Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers. Nutrition. 2010;26(2):175-83.
Lee, S. H., Kang, H. J., Lee, H. J., Kang, M. H., & Park, Y. K. (2010). Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers. Nutrition (Burbank, Los Angeles County, Calif.), 26(2), 175-83. https://doi.org/10.1016/j.nut.2009.03.010
Lee SH, et al. Six-week Supplementation With Chlorella Has Favorable Impact On Antioxidant Status in Korean Male Smokers. Nutrition. 2010;26(2):175-83. PubMed PMID: 19660910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers. AU - Lee,Sun Hee, AU - Kang,Hae Jin, AU - Lee,Hye-Jin, AU - Kang,Myung-Hee, AU - Park,Yoo Kyoung, Y1 - 2009/08/05/ PY - 2008/10/22/received PY - 2009/03/27/revised PY - 2009/03/27/accepted PY - 2009/8/8/entrez PY - 2009/8/8/pubmed PY - 2010/5/28/medline SP - 175 EP - 83 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 26 IS - 2 N2 - OBJECTIVE: Chlorella vulgaris is a popular food supplement in Asia and is currently marketed as a nutritional supplement. However, available scientific studies do not support its effectiveness for preventing or treating any disease in humans. Because Chlorella contains numerous nutrients, including antioxidants, it is thought to exert antioxidative functions by scavenging free radicals created by various environmental factors such as smoking. The purpose of this study was to investigate whether 6 wk of Chlorella supplementation to smokers is protective against oxidative damage in a randomized, double-blinded, placebo-controlled trial. METHODS: Fifty-two smokers, aged 20-65 y, were given 6.3g of Chlorella or placebo every day for 6 wk. Blood samples were drawn at the beginning and after the supplementation. Plasma antioxidant vitamin levels and lipid peroxidation levels were measured. As a marker of oxidative stress, lymphocyte DNA damage was measured. RESULTS: Chlorella supplementation increased plasma vitamin C (44.4%), alpha-tocopherol (15.7%), and erythrocyte catalase and superoxide dismutase activities. Although 6 wk of Chlorella supplementation resulted in a significant decrease in lymphocyte DNA damage, as measured by comet assay, placebo supplementation also decreased the measured amount of lymphocyte DNA damage. CONCLUSION: Chlorella supplementation resulted in the conservation of plasma antioxidant nutrient status and improvement in erythrocyte antioxidant enzyme activities in subjects. Therefore, our results are supportive of an antioxidant role for Chlorella and indicate that Chlorella is an important whole-food supplement that should be included as a key component of a healthy diet. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19660910/Six_week_supplementation_with_Chlorella_has_favorable_impact_on_antioxidant_status_in_Korean_male_smokers_ DB - PRIME DP - Unbound Medicine ER -